Abstract
The purpose in this study is to characterize a regenerative heart valve mechanically which was developed from a porcine aortic valve with our ultra-high pressure method. The result of tensile test on a porcine native valve showed anisotropy in a leaflet. A maximum stress on a circumferential direction was much greater than that on a radial direction. This difference of maximum stress in each direction may depend on orientation of collagen fibers. The tensile property of a human valvular leaflet was similar to the property of a porcine valve. A maximum stress of the regenerative valvelar leaflet was considerably stronger than that of the porcine and the human native leaflet. The thickness of the regenerative valvular leaflet decreased because glycosaminoglycan and other contents were removed from the inside through the decellularization process. Consequently the maximum stress increased although maximum load of the regenerative leaflet was not so different from the native one. This result means that the property of collagen was not affected by our decellularization treatment. The results of this study showed that the regenerative valve could be implanted to a human from the point of tensile property.
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