Abstract
Objective. To perform comparative analysis of osseointegration of bioceramic alumina-based granules, hydroxyapatite-based granules, and granules of deproteinized bone tissue. Material and Methods. The experiment was conducted on 52 adult male Kyoto-Wistar laboratory rats weighing 350 to 520 g. Animals were divided into five matched groups, which differed only in the type of implanted material. Granules were implanted in lumbar vertebral bodies and in distal right femur of each laboratory animal. Two months after surgery animals were euthanized with subsequent tissue sampling for morphological studies. Results. Examination of specimens from groups with implantation of alumina granules revealed the formed trabecular bone with evidence for remodeling. Bone tissue filled the space between granules fitting closely to their surfaces. There was no connective tissue capsule on the border between the bone tissue and alumina granules. Conclusion. Bioceramic alumina-based granules in the form of cylinders with a through inner channel have high strength surpassing that of analogs and ability for osseointegration close to that of hydroxyapatite and deproteinized bone granules.
Highlights
Bioceramic alumina-based granules in the form of cylinders with a through inner channel have high strength surpassing that of analogs and ability for osseointegration close to that of hydroxyapatite and deproteinized bone granules
Minamide A, Yoshida M, Kawakami M, et al The use of cultured bone marrow cells in type I collagen gel and porous hydroxyapatite for posterolateral lumbar spine fusion
Summary
Сравнительный анализ остеоинтеграции алюмооксидных биокерамических гранул в эксперименте. Сравнительный анализ остеоинтеграции биокерамических гранул на основе оксида алюминия, гидроксиапатита и гранул депротеинизированной костной ткани. Через два месяца после операций проводили эвтаназию лабораторных животных с последующим забором тканей для проведения морфологических исследований. При исследовании препаратов из групп с имплантацией алюмооксидных гранул обнаруживалась сформированная костная ткань трабекулярного строения со следами перестройки. Костная ткань заполняла пространство между гранулами и плотно прилегала к их поверхности. Биокерамические гранулы на основе оксида алюминия в виде цилиндров со сквозным внутренним каналом обладают высокой прочностью, превосходящей аналоги, и способностью к остеоинтеграции, близкой к биокерамическим гранулам на основе гидрокисапатита и депротеинизированной костной ткани. Для цитирования: Рерих В.В., Аветисян А.Р., Зайдман А.М., Аникин К.А., Батаев В.А., Мамонова Е.В., Никулина А.А., Аронов А.М., Семанцова Е.С. Сравнительный анализ остеоинтеграции алюмооксидных биокерамических гранул в эксперименте // Хирургия позвоночника.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
