Изучение острой и субхронической токсичности белкового гидролизата

Abstract

The article presents the results of preclinical tests of acute oral toxicity of a protein hydrolyzate. The study of the parameters of acute oral toxicity of the protein hydrolyzate was carried out in the conditions of the Department of Disease Diagnostics, Therapy, Obstetrics and Animal Reproduction of the Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin" and on the basis of the International Research Center for Human Health, Animals and the Environment (OOO MNIC «OZOS»). The experiment included white outbred rats weighing 180–210 g. The weight of the animals is indicated before the administration of the drug. There were 6 individuals in each group. The parameters of the study of acute oral toxicity were determined according to the generally accepted methodology described in the manual for the experimental study of new pharmacological substances R. U. Khabrieva. As a result of the studies, it was found that the LD50 of the protein hydrolyzate from the muscle tissue of sables in the study of acute toxicity parameters was more than 17 850 mg/kg of animal weight. According to the generally accepted hygienic classification, protein hydrolyzate from sable muscle tissue belongs to the 4th hazard class – low-hazard substances (GOST 12.1.007-76).