НОВЫЙ НЕИНВАЗИВНЫЙ СПОСОБ ОЦЕНКИ АЛИМЕНТАРНОЙ ОБЕСПЕЧЕННОСТИ СЕЛЕНОМ IN VIVO

Abstract

Selenium (Se) is essential trace element in human nutrition. The aim of this study was to assess selenium nutritional status by analyzing Se frequency distribution in the long-term biological indicator tissue of hair (H∙Se) and in the short-term biological indicator tissue of whole blood (WB∙Se). Hair selenium was analyzed in 1073 apparently healthy adult Croats (339 ♂ and 734 ♀) and the whole blood selenium was analyzed in a random subsample of 91 ♂ and 143 ♀. Samples were analyzed by the ICP-MS at the Center for Biotic Medicine, Moscow, Russia. There were no significant gender dependent difference in the selenium adequate linear reference range which was (µg∙g1) for H∙Se 0.078–0.701 and for WB∙Se 0.120–0.200, respectively. Hair selenium concentrations below 0.078 and 0.120 for WB∙Se indicate selenium deficiency. The estimated upper adequate selenium limits for H∙Se and WB∙Se are set at 0.701 and 0.200 µg∙g1, respectively. The linear segment of the generated H∙Se logistic distribution sigmoid curve is considered to represent adequate Se intake range. This adequate selenium intake segment can be itself partitioned by a 60:30:10 percentage ratio into Sparsely adequate (♀ 0.078–0.405, ♂ 0.1740.474), Adequate (Optimal) (♀ 0.4050.573, ♂ 0.474–0.608), and Ample adequate segment (♀ 0.5730.623, ♂ 0.608–0.709). These reference dose data are essential for continuous monitoring of the selenium nutritional status and selenium supplementation medication The noninvasive selenium status assessment is especially important when dealing with a vulnerable segments of human population like pregnant and lactating women, and their infants. The Median Derivatives Bioassay provides a new public health asset for general medical practice.