Abstract
Selenium (Se) is essential trace element in human nutrition. The aim of this study was to assess selenium nutritional status by analyzing Se frequency distribution in the long-term biological indicator tissue of hair (H∙Se) and in the short-term biological indicator tissue of whole blood (WB∙Se). Hair selenium was analyzed in 1073 apparently healthy adult Croats (339 ♂ and 734 ♀) and the whole blood selenium was analyzed in a random subsample of 91 ♂ and 143 ♀. Samples were analyzed by the ICP-MS at the Center for Biotic Medicine, Moscow, Russia. There were no significant gender dependent difference in the selenium adequate linear reference range which was (µg∙g1) for H∙Se 0.078–0.701 and for WB∙Se 0.120–0.200, respectively. Hair selenium concentrations below 0.078 and 0.120 for WB∙Se indicate selenium deficiency. The estimated upper adequate selenium limits for H∙Se and WB∙Se are set at 0.701 and 0.200 µg∙g1, respectively. The linear segment of the generated H∙Se logistic distribution sigmoid curve is considered to represent adequate Se intake range. This adequate selenium intake segment can be itself partitioned by a 60:30:10 percentage ratio into Sparsely adequate (♀ 0.078–0.405, ♂ 0.1740.474), Adequate (Optimal) (♀ 0.4050.573, ♂ 0.474–0.608), and Ample adequate segment (♀ 0.5730.623, ♂ 0.608–0.709). These reference dose data are essential for continuous monitoring of the selenium nutritional status and selenium supplementation medication The noninvasive selenium status assessment is especially important when dealing with a vulnerable segments of human population like pregnant and lactating women, and their infants. The Median Derivatives Bioassay provides a new public health asset for general medical practice.
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