Влияние комбинации пропофол и изофлуран на основные физиологические параметры собак

Abstract

The drug development process is usually divided into three main stages: development, preclinical evaluation, and clinical trials. The regulatory requirements of international guidelines usually require toxicological and pharmacological studies on at least two types of laboratory animals: rodents and non-rodents. Beagle dogs are often used as model non-rodents to study the efficacy and safety of newly developed drugs and chemicals due to the similarity of their anatomical morphology and physiology to humans. The work is devoted to the study of the effect of a combination of propofol and isoflurane on basic physiological parameters such as: blood pressure, blood oxygen saturation, capnogram, electrocardiogram, heart rate, respiratory rate, body temperature, glucose level. The study was approved by the local Bioethics Commission. 10 males and 10 females of the Beagle breed aged from 1 to 2 years were used. Initially, propofol was administered to all dogs at a dose of 10 mg / kg intravenously, then an endotracheal tube No. 6.0–-6.5 was installed, 4 minutes after the introduction of propofol, isoflurane was supplied with a flow rate of 1 l /min and a concentration of 2 % of the gas mixture. Based on the conducted research, it was found that the combination of propofol and isoflurane has some depressive effects on the cardiovascular and respiratory systems. At the same time, there was no effect on blood glucose levels and blood oxygen saturation. This combination did not cause hypothermia in dogs in the study. The data obtained indicate good tolerability of combined anesthesia, and allow for the widespread use of a combination of propofol and isoflurane in the anesthesiological provision of dogs.