Objective To investigate the clinical effect of liquid decoction combined with zinc gluconate granule in the treatment of semen non-liquefaction. Methods From May 2016 to February 2017, 68 cases of semen non-liquefier were admitted with an average age of 24 to 43 years, and an average of 25.2 years. Results All patients were followed up and the treatment time was 30-150 days, with an average of 90 days.There were 64 effective cases and 4 invalid cases, the effective rate was 94.1%.And sperm concentration, semen volume, sperm motility significantly increased, dead sperm decreased, abnormal sperm percentage decreased significantly(P<0.05). Conclusions Liquid decoction combined with zinc gluconate granule which is effective to improve the condition of semen in patients with semen non-liquefaction. Key words: SEMEN UNLIQUEFACTION; DRUG THERAPY (TCD); Zinc Compounds