Zhongshan University Research Articles

Online Learning Resource Management System Utilization and College Students' Engagement at Zhongshan University

The study aimed to assess the extent of utilization of the Learning Resource Management System (LRMS) and its impact on student' engagement among 218 college students at ZhongShan College. Utilizing a descriptive correlational approach with a quantitative method, the study found that the students perceived a very high extent of utilization of LRMS, appreciating its clear instructions and regular access to reliable internet. Additionally, the students exhibited high engagement levels with the LRMS regarding online activities, academic relevance, collaboration, and social interaction. Notably, a significant relationship was observed between the extent of LRMS utilization and online academic relevance in students' engagement. The study suggests implementing training programs for students and teachers to enhance LRMS utilization, inform school policies, and promote awareness of its benefits. These findings lay the foundation for future training initiatives and policy enhancements within the educational institution.

Investigation of Stroke Risk Factors and Prognostic Indicators in NVAF Patients with Low CHA2DS2-VASc Scores.

The prognosis of patients with nonvalvular atrial fibrillation (NVAF) with a low CHA2DS2-VASc score (0-1) following a stroke is not well studied. In this investigation, stroke risk factors and prognostic markers in low-risk NVAF patients who are nonetheless at risk for stroke were examined.From January 2012 to January 2022, we retrospectively assessed atrial fibrillation (AF) patients at Xiamen University's Zhongshan Hospital for ischemic stroke. Along with a control group of patients with CHA2DS2-VASc scores of 0-1 who weren't suffering from a stroke, patients with CHA2DS2-VASc scores of 0-1 at the time of stroke were included in the study. Using multivariate logistic regression, independent risk factors were identified. To assess the cumulative occurrences of in-hospital mortality in patients with NVAF-related stroke, the Kaplan-Meier method was used.The study included 156 out of 3.237 inpatients with AF-related stroke who had CHA2DS2-VASc ratings of 0-1. Left atrial diameter (LAD) (odds ratio [OR]: 1.858, 95% confidence interval (CI) 1.136-3.036, P = 0.013), D-dimer (OR: 2.569, 95% CI 1.274-5.179, P = 0.008), and NT-proBNP (OR: 4.558, 95% CI 2.060-10.087, P = 0.000) were found to be independent risk factors for stroke in NVAF patients with a low CHA2DS2-VASc score. During hospitalization, nine patients with NVAF-related stroke died. In patients with NVAF-related stroke, NT-proBNP (hazard ratio: 3.504, 95% CI 1.079-11.379, P = 0.037) was an indicator of mortality risk.Patients with NVAF and CHA2DS2-VASc scores of 0-1 had independent risk factors for stroke in the form of LAD, D-dimer, and NT-proBNP. Notably, in low-risk NVAF patients with stroke, NT-proBNP was discovered to be a potent predictor of in-hospital death.

Therapeutic effects of Naohuan Dan combined with idebenone in treating mild cognitive impairment with kidney deficiency and phlegm stasis: A retrospective study

Abstract Background Naohuan Dan is a prescription used to treat dementia. This study aims to assess the effectiveness and safety of Naohuan Dan combined with idebenone in treating mild cognitive impairment (MCI) with kidney deficiency and phlegm stasis. Materials and methods This retrospective, observational clinical trial enrolled 64 MCI patients treated in the Sun Yat-sen Memorial Hospital, Zhongshan University, from May 1, 2019, to April 30, 2022. The 32 patients in the treatment group received Naohuan Dan combined with idebenone, whereas the 32 patients in the control group were treated with idebenone alone. The observation lasted for 12 weeks. The primary outcomes were the Mini-Mental State Examination (MMSE) score and clinical efficacy, whereas secondary outcomes included the Montreal Cognitive Assessment (MCS) score, the activities of daily living (ADL) score, the Geriatric Depression Scale (GDS) score, the traditional Chinese medicine (TCM) syndrome score, and changes in serum markers. Neuron-specific enolase (NSE), interleukin 8 (IL-8), and tumor necrosis factor α (TNF-α) were taken as the serological indicators for evaluating cognitive function. Adverse events in both groups were recorded during the treatment period. Results The treatment group demonstrated higher MMSE scores and clinical efficacy than the control group, specifically in the scores of spatial orientation, attention and calculation, and language proficiency in the MMSE scale. The treatment group outperformed the control group in MCS, ADLs, GDS, and TCM syndrome scores. Furthermore, the treatment group was superior to the control group in recovering the levels of NSE, IL-8, and TNF-α. In addition, the treatment group had lower incidence of adverse reactions such as nausea and poor appetite than the control group. Conclusions The 12-week treatment with Naohuan Dan combined with idebenone significantly improved the cognitive function and daily life abilities, lowered the depression levels, and reduced the occurrence of adverse events among patients with MCI. These findings offer valuable insights into the efficacy of integrating TCM with Western medicine in the clinical management of MCI. (ClinicalTrials.gov ID: NCT05931029; https://clinicaltrials.gov/study/NCT05931029?cond=Naohuan%20Dan&rank=1)

Exploring the development of intercultural communication skills of language students in universities based on big data

Abstract With the development of globalization, people’s communication becomes more and more frequent. China urgently needs to cultivate talents at the international level and strong foreign language communicative ability to participate in international affairs and follow the international development trend. Based on the data analysis method and machine learning method in big data analysis, this article explores the current situation of intercultural communication ability and competence cultivation of language students in colleges and universities. The article summarizes the existing problems of language students’ intercultural communication ability in Chinese universities based on questionnaires conducted in four universities in southwest, northeast, east, and South China. Secondly, based on the current problems in the intercultural communication competence of language students in Chinese universities, the article further proposes teaching inspirations for the cultivation of intercultural communication competence of language students in Chinese universities. The survey results show that the highest total number of respondents who chose A and B answers, i.e., they think they have strong intercultural communication ability, was 689 from Zhongshan University, accounting for 33.62%, followed by 615 from Shanghai University, accounting for 30.1%; the lowest was 240 from Guizhou University, accounting for 11.7% only, and the level of intercultural communication ability of language students in these four universities can be ranked as follows. Zhongshan University > Shanghai University > Heilongjiang University > Guizhou University. This study can suggest highly rigorous and practical strategies for cultivating language students’ intercultural communication ability in Chinese universities.

Taxonomy of the leafhopper genus Drabescus Stål (Hemiptera: Cicadellidae: Deltocephalinae) with description of two new species from China.

Two new species from China, Drabescus macrocladus sp. nov. and Drabescus mucronatus sp. nov., are described and figured. An updated checklist with distributions and key to males of the species in this genus from China is given. The type specimens of these two new species are deposited in the Entomological Museum, Northwest A&F University, Yangling, Shaanxi, China (NWAFU) and in Sun Yat-Sen University (Zhongshan University, ZSU), Guangzhou, Guangdong, China.

On LHRT’s Seventy-Fifth Anniversary

On LHRT’s Seventy-Fifth Anniversary

Characteristics and trend analysis of Chinese tourism academic research Based on CNKI (1992-2018) bibliometric analysis

Based on the retrieval of journals published on CNKI in the field of tourism, and the statistical analysis by Cite Space, this paper finds that: (1) in terms of the number of published papers, tourism research can be divided into three stages: infancy period in 1992-2000; Steady growth period in 2001-2011 years; Rapid decline period in 2012-2018 years. (2) The key institutions of tourism research are institutions of higher learning, among which Shaanxi Normal University and Zhongshan University have obvious institutional competitiveness. (3) Through the co-occurrence analysis of core authors and key words, eight core author groups and corresponding research fields can be divided. (4) The research direction of tourism mainly focuses on tourism industry, tourism resources, tourism development, tourist, the Belt and Road cultural tourism, rural tourism and city tourism. The future research will focus on the research direction of “big data”, “the Belt and Road tourism”, “poverty alleviation”, “global tourism” and “Rural Revitalization”.

Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI.

The effects of different cytochrome P450 2C19 (CYP2C19) genotypes on the prognosis of clopidogrel resistance in patients complicated with atrial fibrillation taking clopidogrel after percutaneous coronary intervention (PCI) were investigated. Eighty patients who were complicated with atrial fibrillation and treated with clopidogrel antiplatelet therapy after PCI in Meizhou Hospital Affiliated to Zhongshan University from September 2015 to January 2017 were selected, and divided into two groups according to the CYP2C19 genotype: extensive metabolism (EM) group and poor metabolism (PM) group. The related risk factors of clopidogrel resistance were determined, and the platelet aggregation rate and clopidogrel resistance rate were compared between the two groups during treatment. Non-fatal myocardial infarction and serious life-threatening complications in the two groups were observed. The increased total cholesterol level and the history of smoking and drinking were the independent risk factors of atrial fibrillation after PCI. The platelet aggregation rates in the EM group at 1, 3 and 12 months after medication were significantly lower than those in the PM group in the same period (P<0.05). The clopidogrel resistance rates in EM group before medication and at 1, 3 and 12 months after medication were higher than those in PM group in the same period (P<0.05). The onset time of non-fatal myocardial infarction in EM group was earlier than that in PM group (P<0.05), the infarct area was larger than that in PM group (P<0.05), and the left ventricular ejection fraction (EF) after onset was lower than that in PM group (P<0.05). In conclusion, the increased total cholesterol level and the history of smoking and drinking are the independent risk factors of clopidogrel resistance in patients complicated with atrial fibrillation after PCI. The incidence rates of cardiac complications are increased significantly in patients with PM CYP2C19 genotype.

Determination of the Safe Surgical Margin for T1b Renal Cell Carcinoma.

To determine the rational surgical margin for pathological T1b renal cell carcinoma (RCC). This retrospective study included surveys of 60 patients with T1bN0M0 RCC who underwentradical nephrectomy (RN, n = 40) or partial nephrectomy (PN, n = 20) between October 2008 and December2014 at the Sun Yat-sen Memorial Hospital affiliated with Zhongshan University. Specimens were collectedfrom 6 sites at the tumour periphery for RN and PN, and at suspected sites on the tumour surface for PN in addition.The histological subtype, pathological grade, surgical margin, pseudocapsule completeness, distribution of satellitefoci, and largest distance between the extra-pseudocapsule lesion and primary tumour (DEP) were evaluated. Thispaper will analyse the relationships between these factors. The positive surgical margin rate was 10% in patients undergoing PN. The study found no significantrelationships between the incidence of satellite foci and tumour diameter, Fuhrman grade, or histological subtype(all P &gt; 0.05). However, male sex, positive surgical margins, and an incomplete pseudocapsule were associatedwith the incidence of satellite foci (P &lt; 0.05). Cases with satellite foci tended to show positive surgical margins.The DEP was &lt;1.0 mm for all tumours, but there were no significant relationships between the DEP and the tumourdiameter, pathological grade, or histological subtype (P &gt; 0.05). In T1b RCC, a 1-mm surgical margin would be sufficient to attain integrated resection of the primarytumour and its cancerous tissue beyond the pseudocapsule. PN was insufficient to prevent a positive surgical margin,most likely due to the presence of satellite foci.

Clinical features and adverse pregnancy outcomes of new onset systemic lupus erythematosus during pregnancy

Objective: To investigate the clinical characteristics and adverse pregnancy outcomes in pregnant women with new onset systemic lupus erythematosus (SLE) during pregnancy. Methods: The clinical data of 263 pregnancies with SLE in the First Affiliated Hospital of Zhongshan University from 2001 to 2015 were collected and analyzed retrospectively. Results: Of all the 263 pregnancies, 188 were diagnosed before pregnancy and 75 were newly diagnosed during pregnancy. Among the 75 new onset SLE, 27, 31, 14 and 3 cases were diagnosed during first trimester, second trimester, third trimester and puerperium, respectively. Active lupus was noted in 81.3% of the patients with new onset SLE. The main clinical manifestations of new onset SLE were lupus nephritis (57.3%) and thrombocytopenia (38.7%). SLEPDAI scores as well as the prevalence of lupus nephritis, and thrombocytopenia in patients with new onset SLE was higher than those in the previously diagnosed ones (P<0.05). Among the 75 new onset SLE pregnancies, adverse pregnancy outcomesoccurred in 53 patients, including 34 with pregnancy loss, 15with premature, 8with intrauterine growth restriction, 5with fetal distress and5 with neonatal lupus. Compared with patients withnon-newonset SLE, patients with newonset SLEhad a higher prevalence of adverse pregnancy outcomes (56.4% vs 70.7%, P<0.05), and pregnancy loss (21.8% vs 45.3%, P<0.01) but less live birth (78.2% vs 54.7%, P<0.05). Conclusion: Most of the patients with new onset SLE occurred during the first and second trimester. The most common clinical features of new onset SLE were lupus nephritis and thrombocytopenia. Patients with new onset SLE were more prone to active lupus, lupus nephritis and thrombocytopenia, as well as more adverse pregnancy outcomes and pregnancy loss.

Making space for engineering education: the South China Institute of Engineering

ABSTRACTThis article examines the spatial history of an important engineering school during the Republican-Communist transitional years in modern China. I argue that studying the spatiality of engineering education in twentieth-century China is important for two reasons. First, the development of engineering education is a pedagogical priority for both the Nationalist and the Communist Parties, as engineering has dominated the ways in which modern Chinese leadership envisioned the world and the training of many of its most important leaders. Second, the spatial culture of engineering is a technique of power through which the relationship between technical and nontechnical dimensions of engineering practices can be discerned. Drawing from local newspapers, biographies of architects, art and architectural history, and campus publications, the available evidence suggests that while the campus buildings of Zhongshan University during the Republican era exhibit a Canton-specific Lingnan architectural style, such regional characteristic was absent in the newly constructed buildings at the South China Institute of Engineering, of which Zhongshan University was a constituent college during the early Communist era. In addition to the exterior aesthetic style, I also analyze the interior spatial arrangement of SCIE, where the boundary between teaching venues, experimental sites, and industrial shops was not sharply drawn in Communist China, which highlights the eradication of hierarchy among teachers, students, and workers. The spatial history of an engineering school in South China reveals how the efforts to provide space for engineering education reflect a changing geopolitical order in twentieth-century China.

Influence of neutrophil-lymphocyte ratio on radiosensitivity and prognosis in patients with nasopharyngeal carcinoma

Objective To investigate the influence of neutrophil-lymphocyte ratio (NLR) on radiosensitivity and prognosis, the relationship between NLR and clinical features, and the clinical value of NLR in patients with nasopharyngeal carcinoma (NPC). Methods 2006 to 2011 in the cancer center of Zhongshan University admitted to the newly diagnosed nasopharyngeal cancer patients in 266 cases. The association of pretreatment NLR with radiotherapy doses 20, 40, and 60 Gy and therapeutic effect at 3 months after radiotherapy was analyzed, as well as the influence of NLR on overall survival (OS), local recurrence-free (LRF), and distant metastasis-free (DMF) rates. The Kaplan-Meier method was used to calculate survival rates and the log-rank test was used for survival difference analysis. Results NLR showed differences across patients with different T stages and sexes (P=0.039, 0.032). The patients with NLR≤3 had significantly higher OS, LRF, and DMF rates compared with those with NLR>3(P=0.004, 0.025, 0.045). As NLR increased, the radiosensitivity in patients with NPC was reduced gradually, and radiosensitivity showed a significant difference between sensitive group and moderately sensitive group (P=0.043). When the radiotherapy dose was 40 Gy, the tumor regression group had a lower NLR than the residual tumor group (P=0.025). Conclusions In patients with NPC, an increased pretreatment NLR is an adverse prognostic factor, and NLR can be used as a simple and convenient method to evaluate the prognosis of patients with NPC. Key words: Neutrophil-lymphocyte ratio; Nnasopharyngeal neoplasms; Radiosensitivity; Prognosis

Aromia bungii

Aromia bungii

Effects of tobramycin dexamethasone eye ointment for blepharitis: multi-center clinical trial

To realize the effectiveness and security of Tobramycin and Dexamethasone Eye Ointment for blepharitis treatment. Design Case control studies. Participants 148 patients be diagnosed as blepharitis including 81 cases as research group and 67 cases as control group. Multi-center randomized controlled clinical trial. The patients met the inclusion criteria from First Hospital Peking University, Beijing Tongren Hospital, Southwest Hospital, Ophthalmology Center Zhongshan University and Third Hospital Peking University were divided into two groups in Aug. to Dec. 2011. Tobramycin dexamethasone eye ointment was applied to eye lid in research group while patients in control group used tobramycin eye ointment. All patients were informed to apply warm compress to the lids, mechanically washing to the eyelids and artificial tears. At the beginning, the 7(th) day, the 14(th) day and the 28(th) day of treatment, observation of symptom, sign and side effect were recorded. Before treatment the difference of the symptom scores of burning sensation, tears, photophobia and itch of two groups has no statistically significant (t = 1.87, 0.43, -0.64, 0.93, P > 0.05), but the symptom scores have a statistically significant decrease (t = 1.99 - 6.90, P < 0.05) at the 7(th) day, 14(th) day, 28(th) day. Before treatment the difference of signs scores have no statistically significant except the term of new blood vessels (t = 2.32, P = 0.02) while all the signs scores have a statistically significant decrease at the 7(th) day, 14(th) day, 28(th) day. Side effect: the number of patients with elevated intraocular pressure of research and control group is 3 and 1 respectively and the ratio is 3.7% and 1.5%. The tobramycin dexamethasone eye ointment can improve signs and symptoms of blepharitis patients. Some patients have to face with the risk of elevated intraocular pressure and it's necessary to monitor the intraocular pressure.

On the identity of Anchorosternum sinense(Coleoptera: Hydrophilidae: Megasternini)

The monotypic genus Anchorosternum Jia, Wu, &amp; Pu, 2001 (Hydrophilidae: Sphaeridiinae: Megasterinini) was originally described to accomodate A. sinense Jia, Wu &amp; Pu, 2001, then known from four specimens collected in dung in southern China. At the time of its description, Jia. et al. (2001) were unable to compare it with type material of other megasternine taxa occurring in the Oriental region, and as such the genus was largely diagnosed using the key to megasternine genera published by Hansen (1991), which also can be difficult to use without compartive material at hand. Moreover, all four type specimens were lost when the entomological collection of Sun Yat-sen University (formerly Zhongshan University) in Guangzhou, P. R. China, moved to a new building. Consequently, Anchorosternum remained the last megasternine genus with unclear status following the revision of recently described hydrophilid genera by Short &amp; Fikáček (2011) and the revision of the Megasternini described previously by the Chinese authors by Jia et al. (2011).

TACROLIMUS CONCENTRATION-TIME CURVE SHAPE CTCS DOES IT CORRELATE WITH THE KIDNEY TRANSPLANT OUTCOME?

1Transplant Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou/CHINA, 2Department Of Organ Transplantation, First Affiliated Hospital, Sun Yat-sen University, Guangzhou/CHINA, 3Transplantation Center, the First Affiliated Hospital of Zhongshan University, Guangzhou/CHINA

Made in China: Cancer Villages

High incidences of cancer have been reported for villages almost all over China and become an inescapable reality in polluted rural areas [16]. A new phenomenon has appeared in China: Aizheng Cun, ...

Effect of leptin pretreatment on hypoxia-reoxygenation induced apoptosis in human L02 liver cells

Objective To investigate the effect of leptin (LEP) pretreatment on hypoxia-reoxygenation (H/R) induced apoptusis in human L02 liver cells. Methods Human L02 liver cells were obtained from pharmacology laboratory, Zhong-Shan University and cultured in DMEM liquid culture medium in an incubator filled with 5% CO_2 at 37℃. The cells were divided into 6 groups ( n = 6 each) : group control (group C) ; grouphypoxia-reoxygenation (group H/R); group Ⅰ-Ⅳ pretreatment with LEP 100, 200, 400 and 800 μg/L + H/R. In group H/R and group Ⅰ-Ⅳ L02 cells were exposed to 95% N_2-5% CO_2 for 12 h followed by 12 h reoxygenation. In group Ⅰ-Ⅳ the cells were pretreated with LEP 100, 200, 400, 800 μg/L respectively before H/R. At the end of 12 h of reoxygenation, the cells were centrifuged and the supematant was collected for determination of ALT and AST concentrations. Apoptosis in L02 cells was detected by Hoechst 33342/PI staining. Fluorescent quantitative PCR was used to detect Bax and Bcl-2 mRNA expression. Results (1) ALT and AST concentrations were significantly increased after H/R. The increase in ALT and AST concentrations was ameliorated by pretreatment with LEP. (2) The H/R-induced apoptotic changes of the cells were attenuated by pretreatment with LEP. (3) The Bax mRNA and Bcl-2 mRNA expression was significantly increased in group H/R as compared with group C. Leptin pretreatmcnt significantly reduced Bax mRNA expression and increased Bcl-2 mRNA expression as compared with group H/R. Conclusion LEP pretreatment can decrease H/R-indtwed apoptosis in the L02 liver cells by down-regulation of Bax mRNA expression and up-regulation of Bcl-2 mRNA expression. Key words: Leptin; Apoptosis; Hepatocytes; Repedusion injury

Surface Energy of Nanostructural Materials with Negative Curvature and Related Size Effects

Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education, and Department of Physics, Hunan Normal University, Changsha 410081, Hunan, P. R. China, and State Key Laboratory of Optoelectronic Materials and Technologies, Institute of Optoelectronic and Functional Composite Materials, Nanotechnology Research Center, School of Physics Science & Engineering, Zhongshan University, Guangzhou 510275, Guangdong, P. R. China

Characterizing soil preferential flow using iodine–starch staining experiments and the active region model

Characterizing Soil Preferential Flow Using Iodine–Starch Staining Experiments and the Active Region Model Hui- Feng Sheng a , Kang Wang b , Renduo Zhang a, and Hui - Hai Liu c a School of Environmental Science and Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, China b State Key Lab. of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, China c Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA