ABSTRACT The current energy perspective postulates profound presence of Renewable Energy Sources (RESs), resulting in need for optimal DC-DC converter design to assure efficient power conversion and minimise losses. By minimising energy losses and improving power quality, an optimal converter design helps ensure a stable and reliable power supply from RESs, which is essential for meeting the growing demand for clean energy. Therefore, this research introduces an innovative Interleaved BIFRED-Zeta converter configuration, designed to meet all criteria associated with an optimal converter design. The interleaved architecture of converter allows the reduction of current ripples and voltage stress along with the improvement of efficiency. Furthermore, the absence of transformer in converter structure enables it to be simple, cost effective and less bulky. The Interleaved Boost Integrated Flyback Rectifier Energy Storage DC-DC (BIFRED)-Zeta converter duty cycle is adjusted continuously using Cascaded Artificial Neural Network (ANN) Maximum Power Point Tracking (MPPT) to further maximise Photovoltaics (PV) system power output. The capability of suggested converter design is demonstrated by the results obtained using simulation and laboratory prototype implementation. Thereby, a peak efficiency of 97.6% is estimated to be achieved using suggested converter design.