The quantum Zeno effect freezes the evolution of a quantum system subject to frequent measure- ments. We apply a Fisher information analysis to show that because of this effect, a closed quantum system should be probed as rarely as possible while a dissipative quantum systems should be probed at specifically determined intervals to yield the optimal estimation of parameters governing the sys- tem dynamics. With a Bayesian analysis we show that a few frequent measurements are needed to identify the parameter region within which the Fisher information analysis applies