Depression In Young Adults Research Articles

Understanding the prospective associations between neuro-developmental problems, bullying victimization, and mental health: Lessons from a longitudinal study of institutional deprivation.

Studies suggest that children who have experienced neglect are at risk for bullying which in turn increases the risk for poor mental health. Here we extend this research by examining whether this risk extends to the neglect associated with severe institutional deprivation and then testing the extent to which these effects are mediated by prior deprivation-related neuro-developmental problems such as symptoms of inattention, hyperactivity and autism. Data were collected at ages 6, 11, 15, and young adulthood (22-25 years) from 165 adoptees who experienced up to 43 months of deprivation in Romanian Orphanages in 1980s and 52 non-deprived UK adoptees (N = 217; 50.23% females). Deprivation was associated with elevated levels of bullying and neuro-developmental symptoms at ages 6 through 15 and young adult depression and anxiety. Paths from deprivation to poor adult mental health were mediated via cross-lagged effects from earlier neuro-developmental problems to later bullying. Findings evidence how deep-seated neuro-developmental impacts of institutional deprivation can cascade across development to impact social functioning and mental health. These results elucidate cascade timing and the association between early deprivation and later bullying victimization across childhood and adolescence.

Earlier Bedtime and Effective Coping Skills Predict a Return to Low-Risk of Depression in Young Adults during the COVID-19 Pandemic.

To determine the persistent effects of the pandemic on mental health in young adults, we categorized depressive symptom trajectories and sought factors that promoted a reduction in depressive symptoms in high-risk individuals. Specifically, longitudinal analysis investigated changes in the risk for depression before and during the pandemic until December 2021 in 399 young adults (57% female; age range: 22.8 ± 2.6 years) in the United States (U.S.) participating in the National Consortium on Alcohol and NeuroDevelopment in Adolescence (NCANDA) study. The Center for Epidemiologic Studies Depression Scale (CES-D-10) was administered multiple times before and during the pandemic. A score ≥10 identified individuals at high-risk for depression. Self-reported sleep behavior, substance use, and coping skills at the start of the pandemic were assessed as predictors for returning to low-risk levels while controlling for demographic factors. The analysis identified four trajectory groups regarding depression risk, with 38% being at low-risk pre-pandemic through 2021, 14% showing persistent high-risk pre-pandemic through 2021, and the remainder converting to high-risk either in June 2020 (30%) or later (18%). Of those who became high-risk in June 2020, 51% were no longer at high-risk in 2021. Logistic regression revealed that earlier bedtime and, for the older participants (mid to late twenties), better coping skills were associated with this declining risk. Results indicate divergence in trajectories of depressive symptoms, with a considerable number of young adults developing persistent depressive symptoms. Healthy sleep behavior and specific coping skills have the potential to promote remittance from depressive symptoms in the context of the pandemic.

Depression, anxiety and worry in young Pacific adults in New Zealand during the COVID-19 pandemic.

To measure symptoms of anxiety, depression and hopelessness in a sample of young Pacific adults living in Auckland, New Zealand during the 2020/2021 COVID-19 pandemic and identify protective factors. Participants were 267 Pacific adults (58% female) who completed a survey online. Analyses included descriptive statistics, correlations, linear regression and symptom network analysis. Around 25% of the sample scored in the range for moderate to severe anxiety and 10% for moderate to severe depression on standard measures. Almost 40% indicated that they found the first lockdown very stressful and 55% noted that some members of their family found it stressful. Only 16% worried about COVID-19 and their future quite a bit or constantly, while another 25% worried sometimes. Self-compassion and Pacific Identity had moderate, negative correlations, and Worry about COVID-19 had weak positive correlations, with anxiety, depression, hopelessness and perceived stress. These results suggest that, while the prevalence of depression and anxiety are quite high among this population, fostering ethnic identity and self-compassion in Pacific children and adolescents might protect against developing depression and anxiety.

The Relationship Between Obstructive Sleep Apnea And Levels Of Depression And Anxiety In Young Adults

ABSTRACTBackground: Obstructive sleep apnea (OSA) is one of the most common and serious sleep disorders that can cause various neurocognitive disorders such as depression and anxiety. OSA can occur in young adults, whom are in an important developmental age in human life. The relationship between OSA and levels of depression and anxiety has never been studied in young adults, especially college students. Early identification and treatment is expected to have an impact on better quality of life and productivity..Aim: To determine the relationship of OSA with levels of depression and anxiety in young adultsMethods: An observational study with a cross sectional design. Data were obtained from Berlin questionnaire, Zung Self-Rating Depression Scale and Zung Self-Rating Anxiety Scale which were filled out in September-November 2021. Bivariate analysis of OSA's relationship with depression and OSA with anxiety was tested using chi-square test. Multivariate logistic regression analysis was performed to test for confounding variables.Results: There was a significant relationship between OSA and depression (p=0,000, OR 4.07) and OSA and anxiety (p=0,000, OR 4.5) in young adults. Logistic regression analysis showed that gender was a confounding variable of anxiety (p=0.044) in young adults.Conclusion: There is a significant relationship between OSA and levels of depression and anxiety in young adults. Young adults who have OSA are 4.07 times more likely to be depressed than young adults who don’t have OSA. Young adults who have OSA are 4.5 times more likely to experience anxiety than young adults who don’t have OSA. There is a significant relationship between OSA and the level of anxiety controlled by the confounding variable, namely gender.

Patterns of adverse childhood experiences and depressive symptom trajectories in young adults: A longitudinal study of college students in China.

BackgroundAdverse childhood experiences (ACEs) tend to cluster together in daily life, and most studies focus on the level of depression at certain points, but the dynamic process of depression is often neglected. Thus, research is urgently needed to explore the relationship between ACEs pattern and trajectory of depressive symptom levels at multiple time points in order to provides early targeted interventions to those who are most at risk.ObjectiveWe aimed to explore patterns of ACEs, including types and timing, associated with depression trajectories in college students.MethodsA school-based health survey was used to collect data as part of a longitudinal study in two medical college in Anhui province, China. Questionnaires were issued to 3,662 participants aged 17–22 and recorded details of ACEs (types and timing) and depression. Latent class analysis (LCA) was used to identify “patterns” of ACEs type and timing. Depressive symptom trajectories employed latent class growth analysis (LCGA). Multiple logistic regressions were employed to evaluate the relationships between ACEs patterns and depressive symptom trajectories.ResultsWe identified five ACEs patterns: “High neglect/emotional abuse/community violence,” “High neglect/emotional abuse,” “High neglect/family dysfunction,” “High neglect,” “Low ACEs.” We traced three depression trajectories: “High depressive symptom” “Moderate depressive symptom,” “Low depressive symptom.” “High neglect/emotional abuse/community violence,” “High neglect/emotional abuse” and “High neglect/family dysfunction” demonstrated a high risk for “High depressive symptom” and “Moderate depressive symptom.” “High neglect” showed a high risk for “Moderate depressive symptom” but not for “High depressive symptom” (P < 0.05).ConclusionsThe findings address the need for a comprehensive consideration of exposure to childhood adversity associated with the risk of depression in young adults through identifying more problematic ACEs patterns amongst exposed children.

Impact of yoga breathing and relaxation as an add-on therapy on quality of life, anxiety, depression and pulmonary function in young adults with bronchial asthma: A randomized controlled trial

BackgroundThe impact of combinations of yogic practices on bronchial asthma have been studied. Such yoga modules tend to be too lengthy for comfortable practice long-term, giving high dropouts. Returning to conventional medicine despite improvement is common. This study tested a shorter, easier yoga routine to improve asthma condition. Material and methodsSixty young adults aged 18-30 years diagnosed with bronchial asthma of mild to moderate severity were randomly assigned to the Yoga Group, add-on yoga therapy and continuing prescribed medication, or the Control Group, continuing prescribed medication only. Measurements on days 0 and 90, included Asthma Quality of Life Questionnaire, Hamilton Anxiety Rating Scale, Beck’s Depression Inventory and Pulmonary Function Tests. The yoga therapy module, practised 30 mins daily, included four kinds of yoga breathing practices, and ended with guided relaxation. ResultsAll Asthma Quality of Life subdomains improved greatly for the Yoga Group as did Hamilton Anxiety and Becks Depression Inventory scores, t statistics were high (40 -75), all p<.0001. Pulmonary Function also improved greatly in all variables, with smaller t statistics from 2 to 14. The Control Group showed some small improvements. Differences observed in scores were highly significant, with large effect sizes. Finally, no dropouts occurred. DiscussionZero dropouts represents an unprecedented result. The yoga module was completely acceptable to participants, Yoga Group improvements were highly significant. The study indicates that the new yoga module effectively improves quality of life, levels of anxiety, depression and pulmonary function in young adults with above-stated bronchial asthma.

A review on the disparities in the identification and assessment of depression in Black adolescents and young adults. How can clinicians help to close the gap?

Depression among Black youth has been under-identified, misdiagnosed and undertreated leaving many Black youth to suffer with this potentially debilitating condition. Thus, it is crucial to evaluate how to appropriately identify and treat depression in Black adolescents. This review outlines the risk factors for the development of depression in Black adolescents, the barriers they face when attempting to access mental healthcare and culturally sensitive actions steps a primary care provider can take to help increase the appropriate diagnosis and ultimate treatment of depression in Black adolescents. Depression can present differently in Black adolescents, which leads to its under identification or misdiagnosis. Moreover, in recent years, the rate of suicide among Black adolescents has been disproportionately rising faster compared to other race/ethnic groups. There have been multiple barriers identified that can be attributed to these findings such as provider mistrust, cultural stigma against seeking help for mental illness, lack of education in the Black community about how depression presents, and lack of financial resources to access mental healthcare. By understanding the unique experiences and inequities faced by Black youth, a culturally responsive assessment can be performed as the crucial initial step in the diagnostic assessment of their depression.

The effects of a single aerobic exercise session on mood and neural emotional reactivity in depressed and healthy young adults: A late positive potential study.

Depression has been characterized by lowered mood and unfavorable changes in neural emotional reactivity (altered brain responses to emotional stimuli). Physical exercise is a well-established strategy to improve the mood of healthy and depressed individuals. Increasing evidence suggests that exercise might also improve emotional reactivity in healthy adults by increasing or decreasing brain responses to positive or negative stimuli, respectively. It is unknown, however, if exercise could also benefit emotional reactivity in depressed individuals. We investigated the effects of a single aerobic exercise session on mood and emotional reactivity in 24 depressed and 24 matched healthy young adults. Self-reported mood and neural reactivity to emotional pictures (indexed by the EEG late positive potential, LPP) were assessed before and after two experimental protocols: exercise (36 min of moderate-intensity exercise at 75% of maximal heart rate) and seated rest condition (36 min). In the healthy control group, exercise improved self-reported mood and neural emotional reactivity (increasing LPP to positive pictures). In the depressed group, exercise improved self-reported mood; however, it did not affect neural emotional reactivity. Additional analyses performed on both groups revealed that exercise-induced changes in emotional reactivity are associated with the severity of depressive symptoms: the effectiveness of exercise in improving emotional reactivity decreases with the severity of depressive symptoms. Overall, the study further strengthens the claim of a beneficial role of exercise on mood and emotional reactivity. It also suggests that a single aerobic exercise session might have a limited influence on neural emotional reactivity in depressed individuals.

Loneliness and Depression among Adults with Visual Impairment

Loneliness has been termed a social epidemic, especially by people with disabilities; one of them is visual impairment. To our knowledge, no study has obtained specific estimates of depression for young and middle-aged adults with visual impairment (VI). These difficulties may be compounded by discrimination. Observational data revealed that those with sight loss were twice as likely as those with another impairment to have experienced discrimination. There is evidence that individuals with visual impairment have poorer mental health than their impairment-free counterparts. In health care settings, an association between visual impairment and depression has been consistently reported. Greater prevalence of depressive symptoms in those with visual impairment has also been reported. This study aimed to examine the prevalence of and factors associated with loneliness and depression in adults with visual impairment and examine its association with life satisfaction.

Analyzing the role of resilience and life satisfaction as mediators of the impact of COVID-19 worries on mental health.

The aim of this study was to test whether resilience and life satisfaction (two traditional protective factors) mediate between COVID‐19 related worries and the development of symptoms of depression, anxiety, and stress in adolescents and young adults. Participants involved 392 adolescents and young adults (70.20% female) aged between 12 and 25 years (M = 17.05 years, SD = 3.08). Participants completed the COVID‐19 related worries scale, the CD‐RISC to analyse resilience, the Satisfaction with Life Scale, and the Depression, Anxiety, and Stress Scales‐21 to study emotional symptoms. Descriptive analyses and Pearson correlations were conducted, together with a structural equation modeling testing a mediational model and multigroup invariance. Results show that resilience and life satisfaction play a mediating role in the relation between the COVID‐19 related worries and emotional symptoms (depression, anxiety, and stress). This study highlights the role of protective factors on adolescents' and young adults' emotional symptoms during the COVID‐19 pandemic.

Young Adults' Loneliness and Depression During the COVID-19 Pandemic: A Moderated Mediation Model.

Since the outbreak of the COVID-19 pandemic in December 2019, millions of people have been infected with the disease. The COVID-19 pandemic also produced severe mental health problems, such as loneliness and depression. The present study aimed to examine the mediating role of cognitive reappraisal and moderating role of resilience in the relationship between young adults’ loneliness and depression during the pandemic by adopting a cross-sectional research approach. In March 2020, 654 young adults (18–29 years old) were recruited to complete the measures for loneliness, depression, emotion regulation, and resilience. Results found that loneliness was positively and moderately associated with depression (r = 0.531, p < 0.001), and that both loneliness and depression were separately negatively associated with cognitive reappraisal (r = −0.348, p < 0.001; r = −0.424, p < 0.001) and resilience (r = −0.436, p < 0.001; r = −0.419, p < 0.001). The results indicated that both loneliness and depression were not associated with expressive suppression (r = 0.067, p = 0.087; r = −0.002, p = 0.961). The moderated mediation model results revealed that only cognitive reappraisal partially mediated the relationship between loneliness and depression (b = −0.301; Boot 95% CI = −0.388, −0.215). In addition, the results of the moderated mediation model indicated that resilience moderated the association between loneliness and depression (b = 0.035, p < 0.001, Boot 95% CI = 0.014, 0.055), while also moderated the impact of cognitive reappraisal on depression (b = −0.031, p < 0.001, Boot 95% CI = −0.058, −0.005). These findings have practical implications that broaden our understanding of depression in young adults and shed light on how to enhance cognitive reappraisal and resilience as a means of combating depression in this age group during the COVID-19 pandemic.

The Family System Amidst Complex Trauma: A Driving Force to Enhance Resilience and Reduce Depression in Young Adults

To explore the relationships between complex trauma, family cohesion, family environment, resiliency, and depression, the authors employed hierarchical multiple regression and mediation analysis were employed with a sample of 485 young adults. The sample consisted of three groups of participants based on the amount of trauma experienced, those who reported 1–3 trauma experiences, those who reported 3 or more trauma experiences, and those who did not report trauma. Analyses indicated that despite complex trauma experiences, families were still able to cultivate strong family environment and family cohesion, which enhanced resilience in individuals and in turn reduced depression symptoms. Future research, as well as important implications for family counseling with the aim of enhancing family resilience and decreasing depression symptoms, especially as a trauma response, are discussed.

COVID-19 and Its Association with Psychological Health of Children, Adolescents and Young Adults

The COVID-19 pandemic has been causing a severe threat to multiple sectors, including people's psychosocial health. The main objective of this review is to identify the association of COVID-19 pandemic with the psychological health of children, adolescents and young adults. Total 18 primary studies, including most of the studies being cross sectional descriptive studies, were included in the review. The review found that the prevalence of anxiety levels among children ranges from 23.87 % to 38%. Similarly, in adolescents, it ranged from 29.27% to 31% and depression level ranges from 22.28% to 44.5 %. The prevalence of depression in young adults was found to be nearly 82 % while the prevalence of anxiety was found to be nearly 88 %.Most of the studies identified COVID-19 as major factor contributing to anxiety, depression and sleep disorders in children, adolescents and young adults. In the review, almost half of the papers described the factors associated with mental health status due to COVID-19 pandemic. The major factors to increase anxiety and depression were found to be restriction on movement, social distancing, closures of schools, little interaction with peers, educational status, smartphone and internet addiction, frequent watching, listening, or reading news related with COVID-19. Thus, efforts must be initiated to improve services within the country to overcome the increasing mental health problems in these groups. The findings of this review would be relevant for all health professionals, medical persons, and educational institutions to sensitize them about the prevalence of psychological problems among children, adolescents and young adults in terms of overcoming and addressing this pressing issue.

P406. Chronic Adolescent Social Instability Stress Leads to Impaired Recognition Memory and Increased Hippocampal FKBP5 and CRHR2 Expression in Adulthood

Recently published studies indicate that the Covid-19 pandemic has dramatically increased rates of anxiety, depression, and suicide in adolescents and young adults. Human and animal studies strongly indicate that early life stress leads to lasting changes to cognition and psychiatric outcomes, but less is known about how chronic adolescent stress may alter brain function across the lifespan.

Does Mobile Internet Use Affect the Depression of Young Chinese Adults? An Instrumental Variable Quantile Analysis

Background: With the advancement of the digital age, the links between mobile Internet use (MIU) and mental health have attracted the attention of scholars. This paper focuses on the relationship between MIU and depression across the entire distribution of young adults’ depression. Methods: Based on nationally representative data from the 2018 China Family Panel Studies (CFPS), we explore whether and to what extent MIU affects depression in young adults in China through instrumental variables. In addition, we employ a quantile regression approach to explore the depression–MIU gradients and examine potential mediation mechanisms by exploiting variation in several potential intermediates available. Results: 2SLS estimate suggests that MIU is associated with a decrease in young adults’ depression by 1.526 points. Besides, the effect of MIU was only significantly negative at the 0.8 to 0.96 quantiles. Discussions: MIU reduces the level of depression in people with higher levels of depression, older age, and who use the Internet for communicative purposes. However, there is no significant gender difference in MIU. In addition, young people will improve their feeling of social comparison when using mobile Internet, thus making them less depressed. Conclusions: MIU has a significant positive impact on depression among young Chinese adults.

Depression and anxiety symptoms in adolescents and young adults in Greece: Prevalence and associated factors

Few studies have investigated depression-anxiety in adolescents/young adults in Greece. We examined the prevalence of depression/anxiety and its correlates in a large, representative, population-based sample of young Greeks. A structured telephone questionnaire was conducted in 2771 adolescents/young adults aged between 15 and 24 years (mean age: 20.47 ± 2.83 years). Depression/anxiety symptoms were assessed using the PHQ-9 and GAD-7 scales, respectively. Sociodemographics, mental health, and psychological parameters were also examined. Moderate to severe depression and anxiety symptoms were defined with PHQ-9≥10 and GAD-7≥10, respectively. Analysis was conducted using multivariable linear and logistic regression models. In our sample, 803 (29%) and 416 (15%) participants reported depressive and anxiety symptoms, respectively. In multivariable analysis, depression was associated with female sex, younger age, mental health history, substance use, dyslexia, lower quality of life and social seclusion (all p < 0.05). Within youth with mental health history, depression was associated with younger age, female sex, dyslexia, attention difficulties, and substance use (p < 0.05). Multivariable analysis revealed similar to depression associations between anxiety and sociodemographic and clinical correlates. Mental health history plus attention/learning problems and substance use was associated with a 57% chance of being depressed. Neither depression nor anxiety was associated with unemployment/low income. Due to cross-sectional design, causality between correlated factors cannot be examined. Depression and anxiety symptoms among youth in Greece are frequent and associated more with previous mental health history and co-existing attention/ learning difficulties, and substance use, rather than known socioeconomic factors. These results may affect preventive health strategies’ priorities.

Recurrent depression has persistent effects on cognition but this does not appear to be mediated by neuroinflammation

BackgroundLater-life depression appears to be different to depression in younger adults. The underlying pathology may also differ. Depression is linked to dementia but whether it is a risk factor or an early sign of a developing dementia remains unclear. Neuroinflammation is increasingly recognised in both depression and Alzheimer's Disease. AimsTo investigate the link between depression, inflammation and dementia. We hypothesised that recurrent depression has adverse effects on performance in cognitive tests in middle to older age and that this effect is modified by anti-inflammatory medication. MethodsWe identified UK based cohort studies which included individuals aged >50, had medical information, results from detailed cognitive testing and had used reliable measures to assess depression. Individuals with recurrent depression had ≥ 2 episodes of depression. Controls had no history of depression. The presence/absence of inflammatory illness was assessed using a standardised list of inflammatory conditions. Individuals with dementia, chronic neurological and psychotic conditions were excluded.Logistic and linear regression were used to examine the effect of depression on cognitive test performance and the mediating effect of chronic inflammation. ResultsUnexpectedly in both studies there was evidence that those with recurrent depression performed better in some cognitive tasks (e.g Mill Hill vocabulary) but worse in others (e.g. reaction time). In UK Biobank there was no evidence that anti-inflammatories moderated this effect. LimitationsCross-sectional assessment of cognition. ConclusionsAlthough previous recurrent depression has small effects on cognitive test performance this does not appear to be mediated by chronic inflammatory disease.

Pharmacotherapy for late-life depression

Background: Late-life depression (LLD) is one of the most common psychiatric disorders. However, LLD is often undetected or inadequately treated by clinicians. This review summarizes the recent research on pharmacotherapy for LLD, updates information on monotherapy using recommended antidepressants, and discusses the clinical features and diagnostic criteria for LLD.Current Concepts: The diagnostic criteria for depression in both elderly and young adults are identical. Clinical features of the elderly with depression more likely include more comorbid medical conditions and cognitive impairment than those of young adults. Depression in the elderly tends to have a more chronic course with frequent recurrences or relapses.Discussion and Conclusion: The current pharmacological treatment guidelines for LLD recommend the use of selective serotonin reuptake inhibitor (SSRI), serotonin-norepinephrine reuptake inhibitor, bupropion, mirtazapine, and vortioxetine as first-line medications. SSRIs, among them, are recommended first because they present fewer serious adverse effects and more clinical evidence than those of other antidepressants. Before starting antidepressant treatment for LLD, clinicians should consider patients’ comorbid medical conditions, drug interactions, possible adverse effects of antidepressants, and polypharmacy. The starting dose of antidepressants for elderly patients should be half of that prescribed for young adults to minimize the adverse effects; however, most elderly patients need the same antidepressant doses as that prescribed for young patients. After remission, a 1-year maintenance treatment is required to prevent recurrence or relapse of LLD.

Adverse childhood experiences and severity levels of inflammation and depression from childhood to young adulthood: a longitudinal cohort study

Adverse childhood experiences (ACEs) are associated with depression and systemic inflammation in adults. However, limited longitudinal research has tested these relationships in children and young people, and it is unclear whether inflammation is an underlying mechanism through which ACEs influence depression. We examined the longitudinal associations of several ACEs across different early-life periods with longitudinal patterns of early-life inflammation and depression in young adulthood and assessed the mediating role of inflammation. The data came from the Avon Longitudinal Study of Parents and Children (N = 3931). ACEs from the prenatal period through to adolescence were operationalised using cumulative scores, single adversities, and dimensions derived through factor analysis. Inflammation (C-reactive protein) was measured on three occasions (9–18 years) and depressive symptoms were ascertained on four occasions (18–23 years). Latent class growth analysis was employed to delineate group-based trajectories of inflammation and depression. The associations between ACEs and the inflammation/depression trajectories were tested using multinomial logistic regression analysis. Most types of ACEs across all early-life periods were associated with elevated depression trajectories, with larger associations for threat-related adversities compared with other ACEs. Bullying victimisation and sexual abuse in late childhood/adolescence were associated with elevated CRP trajectories, while other ACEs were unrelated to inflammation. Inflammation was also unrelated to depression and did not mediate the associations with ACEs. These results suggest that ACEs are consistently associated with depression, whereas the associations of inflammation with ACEs and depression are weak in young people. Interventions targeting inflammation in this population might not offer protection against depression.

The association between the social environment of childhood and adolescence and depression in young adulthood - A prospective cohort study

BackgroundGood social relationships with parents and peers protect children and adolescents from developing mental disorders in adulthood while several negative experiences increase the risk of depression in later life. MethodsWe used population-based cohort data from the Northern Finland Birth Cohort (NFBC) 1986. Participants (n = 6147), their teachers and parents reported factors associated with the social environment of children and adolescents. Diagnoses of depression of cohort members were derived from Finnish nationwide registers. We conducted regression analyses to assess which factors of the social environment of childhood and adolescence were associated with depression in young adulthood. ResultsBullying victimization in adolescence was the strongest predictor of depression in young adulthood among girls (OR 2.23: 95% CI 1.47–3.39) and boys (OR 2.44: 95% CI 1.49–4.00). Loneliness and bullying behavior in childhood were associated with depression in boys only. Loneliness in adolescence (OR 1.63: 95% CI 1.30–2.04) was associated with depression among both genders. Spending with the family seemed to protect against the negative impact of bullying and loneliness. LimitationsWe used single-item study questions to measure social relationships. These questions do not necessarily describe the phenomena as accurately as the measures validated for them. ConclusionProblems in social relationships with peers in childhood and adolescence are associated with depression in young adulthood. Time spent with the family is emphasized in situations in which adolescents have problems in peer-relationships.