P406. Chronic Adolescent Social Instability Stress Leads to Impaired Recognition Memory and Increased Hippocampal FKBP5 and CRHR2 Expression in Adulthood

Abstract

Recently published studies indicate that the Covid-19 pandemic has dramatically increased rates of anxiety, depression, and suicide in adolescents and young adults. Human and animal studies strongly indicate that early life stress leads to lasting changes to cognition and psychiatric outcomes, but less is known about how chronic adolescent stress may alter brain function across the lifespan.