Years Of Age In Korea Research Articles

Analysis of Risk Factors for COPD Incidence in Adults Over 40 Years of Age in Korea

Analysis of Risk Factors for COPD Incidence in Adults Over 40 Years of Age in Korea

Association between Chronic Atrophic Gastritis and Bone Mineral Density among Women Older than 40 Years of Age in Korea.

Chronic atrophic gastritis causes hypochlorhydria, hypergastrinemia, and malabsorption of nutrients, leading to lower bone mineral density. The few studies that investigated the association between chronic atrophic gastritis and bone mineral density have reported inconsistent findings. As such, the present study assessed the association between chronic atrophic gastritis and bone mineral density among a large sample of women >40 years of age in Korea. Data from 8,748 women >40 years of age who underwent esophagogastroduodenoscopy and bone densitometry were analyzed. Chronic atrophic gastritis was diagnosed using esophagogastroduodenoscopy. Bone mineral density of the lumbar vertebrae (L), femur neck, and femur total, measured using dual-energy X-ray absorptiometry, were the primary outcome variables. Low bone mineral density, which could be diagnosed as osteoporosis or osteopenia, was defined and analyzed as a secondary outcome. Linear regression was used to calculate adjusted mean values of bone mineral density. The association between low bone mineral density and chronic atrophic gastritis was analyzed using multiple logistic regression. The adjusted mean bone mineral density for L1-L4 was 1.063±0.003, femur neck (0.826±0.002), and femur total (0.890±0.002) were significantly lower in patients with chronic atrophic gastritis than others (1.073±0.002, 0.836±0.001, 0.898±0.002, respectively; all P<0.01). Women with chronic atrophic gastritis exhibited an increased likelihood for osteopenia or osteoporosis, even after adjusting for age and other confounding factors (odds ratio, 1.25; 95% confidence interval, 1.13-1.40; P<0.01). However, subgroup analysis revealed statistical significance only in postmenopausal women (odds ratio, 1.27; P<0.001). Chronic atrophic gastritis was associated with lower bone mineral density and a higher risk for osteopenia or osteoporosis among postmenopausal women.

Association between Dyslipidemia and Glycated Hemoglobin in a Population-Based Study.

Diabetes mellitus and dyslipidemia are well-known risk factors for cardiovascular disease. Unfortunately, the prevalence of dyslipidemia and diabetes mellitus among individuals over 30 years of age in Korea has continuously increased. The current study therefore investigated the association between dyslipidemia and high glycated hemoglobin (Hemoglobin A1c, HbA1c) levels according to age group in adults over 20 years old. We used data from the 7th Korea National Health and Nutrition Examination Survey conducted by the Korea Centers for Disease Control and Prevention from 2016 to 2017. Glycated hemoglobin, a well-established marker for elevated glucose levels, was categorized into three groups, normal (<5.7%), prediabetes (5.7-6.4%), and diabetes (≥6.5%). The presence of dyslipidemia was defined based on a diagnosis of dyslipidemia by a physician. Logistic regression analyses were performed to evaluate the association between the prevalence of dyslipidemia and glycated hemoglobin according to age group. After adjusting for possible confounders, including age, sex, body mass index, marital status, education, occupation, household income, drinking, and smoking, we found a significant increase in the odds ratios (ORs) for dyslipidemia in the prediabetes (OR; 1.915, 95% CI; 1.696 to 2.163) and diabetes (OR; 3.533, 95% CI; 3.019 to 4.134) groups. Among subjects with higher glycated hemoglobin levels, those in their 40s or over had significantly increased odds for dyslipidemia. The current study found an association between high glycated hemoglobin levels and a diagnosis of dyslipidemia among Korean adults. Markers of lipid metabolism in adults with high glycated hemoglobin levels may need to be monitored, especially those in their 40s and older.

Association between household income levels and nutritional intake of allergic children under 6 years of age in Korea: 2019 Korea National Health and Nutrition Examination Survey and application of machine learning.

This study investigated the prevalence of allergic diseases in Korean children aged 6 and below, focusing on the interplay between nutritional status, household income levels, and allergic disease occurrence. This study used data from the 2019 Korea National Health and Nutrition Examination Survey, a nationwide comprehensive survey, and included a representative sample of 30,382 children under the age of 6 to investigate in detail the relationship between allergic diseases, nutritional intake, and socioeconomic factors. Logistic regression analysis was performed to identify factors associated with allergic diseases, including gender, BMI, eating habits, dietary supplement intake, and nutrient consumption. To predict childhood asthma, 14 machine learning models were compared using the 'pycaret' package in Python. We discerned that 24.7% were diagnosed with allergic conditions like atopic dermatitis, asthma, and allergic rhinitis. Notably, household income exhibited a significant influence, with the lowest income quartile exhibiting higher prevalence rates of asthma, allergic rhinitis, and multiple allergic diseases. In contrast, the highest income quartile displayed lower rates of allergic rhinitis. Children diagnosed with allergic diseases demonstrated compromised intake of essential nutrients such as energy, dietary fiber, vitamin B1, sodium, potassium, and iron. Particularly noteworthy were the deficits in dietary fiber, vitamin A, niacin, and potassium intake among children aged 3-5 with allergies. Logistic regression analysis further elucidated that within low-income families, female children with higher BMIs, frequent dining out, dietary supplement usage, and altered consumption of vitamin B1 and iron faced an elevated risk of allergic disease diagnosis. Additionally, machine learning analysis pinpointed influential predictors for childhood asthma, encompassing BMI, household income, subjective health perception, height, and dietary habits. Our findings underscore the pronounced impact of income levels on the intricate nexus between allergic diseases and nutritional status. Furthermore, our machine learning insights illuminate the multifaceted determinants of childhood asthma, where physiological traits, socioeconomic circumstances, environmental factors, and dietary choices intertwine to shape disease prevalence. This study emphasizes the urgency of tailored nutritional interventions, particularly in socioeconomically disadvantaged populations, while also underscoring the necessity for comprehensive longitudinal investigations to unravel the intricate relationship between allergic diseases, nutritional factors, and socioeconomic strata.

Effects of once-weekly dulaglutide on juvenile type 2 diabetes mellitus and obesity in Korea: a pilot study.

We sought to investigate the effects and side effects of once-weekly dulaglutide treatment for type 2 diabetes mellitus (T2DM) in patients <18 years of age in Korea. : From the Eulji University Hospital database, we identified all patients <18 years of age diagnosed with T2DM and treated with dulaglutide from January 1, 2017, to July 31, 2022. We identified 5 patients <18 years of age treated with dulaglutide for T2DM management. Their mean (standard deviation [SD]) age was 16.6 (0.5) years. Four (80%) patients were female. The mean (SD) body mass index was 29.4 (5.1) kg/m2, and the mean (SD) age at diagnosis was 15.2 (1.6) years. Four patients had been treated previously with metformin alone or in combination with insulin. Four patients were treated with 1.5 mg of dulaglutide and one was treated with 0.75 mg of dulaglutide. The mean (SD) hemoglobin A1c concentrations at baseline, 3 months after treatment, and 1 year after treatment, respectively, were 10.0% (2.2%), 6.5% (1.5%), and 6.7% (1.4%), with significant differences. In addition, at baseline, 3 months after treatment, and 1 year after treatment, the mean (SD) body weight values were 79.7 (13.3) kg, 80.2 (14.0) kg, and 81.1 (15.3) kg, with no significant difference. Use of once-weekly dulaglutide for juvenile T2DM ensures very good glycemic control, with few side effects and good adherence, indicating its potential as a promising therapeutic agent in this age group. Nationwide studies are warranted to confirm our results.

Relationship between remaining teeth and mental health indicators in adults over 50 years of age in Korea

Relationship between remaining teeth and mental health indicators in adults over 50 years of age in Korea

2149. Risk of dental abnormalities after tetracycline exposure in children: A retrospective, population-based study in Korea, 2003-2015

Abstract Background Despite its clinical usefulness, the use of tetracycline antibiotics (TCs) in children has historically been limited because of the risk of permanent tooth discoloration and enamel deformity, although age restrictions have varied across countries (e.g., contraindicated under 8 years of age in Taiwan, USA, and Canada, and under 12 years of age in Korea and UK). We explored whether the incidence of dental abnormalities in Korean children with a history of TCs use differed by age. Furthermore, the relative risk compared to the TCs non-exposed group was calculated. Methods From 2002 to 2015, 1 million standard sample subjects data was provided from National Health Insurance Service in Korea. Children younger than 18 years were included and divided into groups A (0-7 years), B (8-12 years), and C (13-17 years). Subjects in 2002 were excluded for wash-out, as were those diagnosed with dental abnormalities within 6 months after TCs prescription. For comparison, 1:4 matching between the TCs exposure and non-exposure groups was performed according to age and gender. Results Among 14,831 individuals included as study subjects (487 (3%) in group A; 1,695 (11%) in group B; and 12,649 (85%) in group C), 201 (1.4%) were diagnosed with dental abnormalities. The 5-year cumulative incidence of dental abnormalities after exposure to TCs in the group A was 4.7%, which was significantly higher than that of the control group C (0.9%; p&amp;lt; 0.0001), but that of group B was 1.3% and not significantly different from that of group C. In the risk analysis of dental abnormalities according to exposure of TCs, there was no significant difference (adjusted RR=1.03, 95%CI=0.71 to 1.50 in group A; adjusted RR=1.13, 95%CI=0.76 to 1.69 in group B; adjusted RR=1.18, 95%CI=0.97 to 1.43 in group C). Fig 1.Cumulative incidence rate and relative risk analysis.A. Cumulative incidence rate of dental abnormalities after TCs exposure by age group (p = &amp;lt;.00001). B. Relative risk analysis by TCs exposure and age group.Abbreviation; TCs: tetracycline and its derivatives. Conclusion Korean children aged 0-7 years who were exposed to TCs had a higher cumulative incidence and relative risk of dental deformities compared to the 13-17-year-old group but not the 8-12-year-old group. No significant increase in dental abnormalities was observed with TCs exposure among pediatric age groups. Disclosures All Authors: No reported disclosures.

Association between Stress Perception and Physical Activity in Elderly

Purpose: The purpose of this study was to investigate the relationship of stress perception and physical activity in the elderly over 60 years of age in Korea. Methods: This s tudy was a s econdary d ata analysis and used d ata from the 8 th 2 nd ( 2 02 0) National Health and Nutrition Examination Survey (KNHANES) as raw data. The subjects of this study were 2,360 elderly people aged 60 years or older from raw data. Data analysis was performed using IBM SPSS 25 ver. Descriptive statistics, chi-square analysis and complex sample logistic regression analysis were performed. Results: Household income, women, subjective health perception, walking were related to stress perception. In result of complex sample logistic regression analysis after adjusting the control variables, the stress perception in 60-69 ages was 2.064 times higher in the case of '1-2 days' walking per week compared to 'more than 3 days' walking per week. The stress perception in 70 years and older was 1.801 times higher in the case of 'none' walking per week compared to 'more than 3 days walking per week. Conclusion: The results provide a basis information for developing an intervention program to improve the stress management and develop a program for healthy aging.

Effects of Frequent Smartphone Use on Sleep Problems in Children under 7 Years of Age in Korea: A 4-Year Longitudinal Study.

The use of electronic screen devices has a negative effect on sleep. The purpose of this study is to longitudinally examine the effects of various screen use on sleep problems in children under 7 years of age. A total of 314 caregivers of children aged 4–7 years from three cities in Korea were recruited and responded to a self-administered questionnaire from 2017 to 2020. As a result of the analysis of the mixed model designed as a two-leveled structure, the use frequency of smartphones significantly predicted children’s sleep problems (β = 0.328, p < 0.001) compared to that of TV, PC, and tablet PC. In addition, the frequency of smartphone screen use showed a weak but significant correlation with bedtime resistance (r = 0.067, p = 0.009), sleep duration (r = 0.089, p <0.001), nighttime awakening (r = 0.066, p = 0.010), and daytime sleepiness (r = 0.102, p < 0.001). The results of this study suggest that screen time education in Korea should focus on smartphones above all else.

Substitute Textile Preferences for Eco-Friendly Leather Goods: Focusing on Shoes and Bags

In the 21^st century, the demand for eco-friendly leather, such as eco-leather and vegan leather, is steadily increasing. This study examines the influence of eco-friendliness on consumers’ purchasing intentions and the possibility of eco-friendly changes in the fashion accessory market, which is dominated by leather material and leather substitutes. This study administered a questionnaire survey to 227 males and females between 20 and 60 years of age in Korea. With a 5-point Likert scale, data were collected on evaluation criteria when purchasing shoes and bags and purchasing intention of various leather substitute materials according to the democratic variables. The eco-friendliness attitude was divided into eco-consciousness and green behavior. As the eco-friendly attitude increased, most purchasing standards increased, but the purchasing criteria, such as trends, brands, and prices, did not correlate with the eco-friendly attitude. The eco-consciousness of a consumer had a high correlation with the design evaluation criteria, while the green behavior of the consumer aligned with durability and comfort criteria when purchasing a bag. There was a preference for recycled leather, vegetable leather, synthetic leather, and chemical leather, and the fabric type was ranked as natural fiber, biodegradable fiber, and synthetic fiber. Consumers with both green behavior and eco-consciousness are more likely to purchase biodegradable textiles and vegetable leather for the material of shoes and bags.

Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea.

Background/Aim: Previous studies have suggested that the short-term ambient air pollution and temperature are associated with myocardial infarction. In this study, we aimed to conduct a time-series analysis to assess the impact of fine particulate matter (PM2.5) and temperature on acute myocardial infarction (AMI) among adults over 20 years of age in Korea by using the data from the Korean National Health Information Database (KNHID). Methods: The daily data of 192,567 AMI cases in Seoul were collected from the nationwide, population-based KNHID from 2005 to 2014. The monitoring data of ambient PM2.5 from the Seoul Research Institute of Public Health and Environment were also collected. A generalized additive model (GAM) that allowed for a quasi-Poisson distribution was used to analyze the effects of PM2.5 and temperature on the incidence of AMI. Results: The models with PM2.5 lag structures of lag 0 and 2-day averages of lag 0 and 1 (lag 01) showed significant associations with AMI (Relative risk [RR]: 1.011, CI: 1.003–1.020 for lag 0, RR: 1.010, CI: 1.000–1.020 for lag 01) after adjusting the covariates. Stratification analysis conducted in the cold season (October–April) and the warm season (May–September) showed a significant lag 0 effect for AMI cases in the cold season only. Conclusions: In conclusion, acute exposure to PM2.5 was significantly associated with AMI morbidity at lag 0 in Seoul, Korea. This increased risk was also observed at low temperatures.

Obesity and sleep mismatch between weekends and weekdays in the Korean population according to working status

ObjectivesTo investigate whether sleep mismatch between weekends and weekdays is correlated with obesity according to working status and sex in the Korean population. Study designThis study was conducted using data from the Korea National Health and Nutritional Examination Survey (KNHANES) in 2016. A total of 5,684 subjects (2,453 men and 3,231 women) were divided into subgroups according to age, sex and working status. Sleep mismatch was defined as the difference in sleep duration between weekdays and weekends. In this study, multivariable logistic regression analysis was applied to obtain odds ratios (ORs) for obesity in those with sleep mismatch ≥ 90 min when referenced to those with sleep mismatch < 90 min. Main outcome measuresIn the working group, adjusted ORs for obesity were mostly less than 1, but they were not statistically significant among any age or sex groups. However, for the non-working group, men over 60 years of age with sleep mismatch ≥ 90 min showed significantly increased ORs when referenced to those with sleep mismatch < 90 min in every model; the OR in model 4 was 2.89. Women over 60 years of age with sleep mismatch ≥ 90 min also showed higher ORs but they were not statistically significant. ConclusionsMen who are not working and over 60 years of age in Korea may be at increased risk of obesity if their sleep mismatch is ≥ 90 min. Therefore, it might be possible to lower the prevalence of obesity in the elderly population by correcting sleep irregularity or through reemployment.

Association between Sleep Patterns and Health Indicators and Diseases in Adults Over 19 Years of Age in Korea: Based on the Korea National Health and Nutrition Examination Survey 2016–2017

Association between Sleep Patterns and Health Indicators and Diseases in Adults Over 19 Years of Age in Korea: Based on the Korea National Health and Nutrition Examination Survey 2016–2017

Association between ambient fine particulate matter and seasonal variation in acute myocardial infarction morbidity

TPS 683: Short-term health effects of air pollutants 2, Exhibition Hall, Ground floor, August 28, 2019, 3:00 PM - 4:30 PM Background/Aim: Environmental factors may play a role in the development of cardiovascular diseases and some studies have shown that ambient air pollution is associated with the myocardial infarction. This study was designed to investigate the impact of ambient air pollution on acute myocardial infarction (AMI) among adult over 20 years of age in Korea by using the data from the Korean National Health Information Database (KNHID) Methods: This study used the nationwide, population-based database from the KNHID collected between 2002 and 2015. Data analysis was performed from January 1, 2005 to December 31, 2014 since the ambient fine particulate matter (PM2.5) monitoring data from Seoul Research Institute of Public Health and Environment were available in these periods. Data on 197,940 AMI case counts in Seoul were collected. Meteorological data were collected from the Korea Meteorological Administration (KMA). We used the Poisson regression analysis adjusted for calendar time, current-day temperature, dew-point temperature, relative humidity to explore the association between PM2.5 and AMI. Results: The mean daily PM2.5 concentrations was 25.9μg/m3 with a range from 23.0 to 544μg/m3. In the Poisson regression analysis of PM2.5, the models with lag structures of lag 0 day and 2-day average of lags 0 and 1 (lag01) showed significant association with AMI (RR:1.017, CI:1.008-1.025 for lag0, RR:1.014, CI: 1.005-1.023 for lag01). There were dose-response relationships of PM2.5 concentration and AMI at lag0 and lag01. In the stratified analysis carried out in the cold season (October-April) and warm season (May-September) showed the significant lag 0 effect for AMI cases in the cold season only. Conclusions: In conclusions, our results have demonstrated that the PM2.5 concentration was significantly associated with AMI morbidity at lag 0 in Seoul, Korea. This increased risk was also observed in cold season and future prospective studies are needed to determine the causal association.

The Association Between the Number of Natural Remaining Teeth and Appendicular Skeletal Muscle Mass in Korean Older Adults.

BackgroundThe aim of this study was to examine the correlation between the number of remaining natural teeth (NRT) and the appendicular skeletal muscle mass index (SMI) in older adults.MethodsThis study was based on data from the 2008–2010 Korea National Health and Nutritional Examination Surveys. The participants were 2,378 older participants (984 men and 1,394 women) aged over 65 years. Survey dentists conducted oral health examinations, and ASM was measured using dual-energy X-ray absorptiometry.ResultsThe participants with NRT≥20 had more ASM and SMI than those with NRT<20 in both sexes. SMI was correlated with NRT in men (r=0.018, p<0.001) and in women (r=−0.007, p<0.001). The positive correlation between the NRT and SMI remained significant in men even after adjusting for age, marital status, income, smoking, drinking, physical activity, protein intake, energy intake, calcium intake, body mass index, fasting blood glucose level, medications, and prostheses (β=0.011, p=0.001). In women, the correlation disappeared after adjustment for smoking, alcohol, physical activity, protein intake, energy intake, calcium intake, marital status, income, fasting basal glucose, medication administration, and prostheses.ConclusionThis study showed a correlation between NRT and SMI in those ≥65 years of age in Korea. The relationship persisted in men, but not in women, even after adjusting for confounders.

Postnatal Exposure of PM10 and Autistic Behaviours among Children: The Mothers and Children's Environmental Health (MOCEH) Study

Background/AimEnvironmental factors may play a role in the development of neurodevelopment and some studies have shown that ambient air pollution is associated with the autistic behaviours. The study was designed to investigate the impact of outdoor air pollution on autistic behaviours among children at 4, 5 years of age in Korea by using MOCEH cohort study's data.MethodsThis study is a part of the Mothers and Children's Environmental Health (MOCEH) study, a Korean multi-center prospective birth cohort study initiated in 2006. After delivery, children were followed up at 48 and 60 months of age. Average exposure level of particulate matter (PM10) were estimated using the inverse distance weighting (IDW) method from prenatal period to postnatal period. A total of 322 mother-child pairs were included. Autistic behaviours were assessed using the Social Responsiveness Scale (SRS) at 4, 5 years of age. We also examined the result stratified by sex of the children.ResultsThe average levels of PM10 during pregnancy and 3 years of age were 54.07&amp;#956;g/m3 and 50.08&amp;#956;g/m3 each. In a multiple linear regression model, although we couldn&amp;#8217;t find significant positive relationship between exposure of PM10 in children, we found that PM10 at 3 years of age was associated with increased scores of SRS T-scores at 5 years of age in boys. (&amp;#946;&amp;#61;0.36, 95% confidence interval [CI]: 0.05,0.66) However, there was no significant positive association in girls.ConclusionsIn conclusions, postnatal exposure of PM10 is associated with the autistic behaviours, in boys at 4, 5 years of age. Further study on the other air pollutants effects to autistic behaviours in children is recommended.

Seroprevalence of Human Parainfluenza Virus Types 1-4 Among Healthy Children Under 5 Years of Age in Korea.

Human parainfluenza viruses (HPIVs) are among the major causes of respiratory infections in children, worldwide, including in Korea. There are four types of HPIVs, each with different epidemiological characteristics. HPIV3 is the most frequently circulating HPIV type, while the epidemiology of HPIV4 remains unclear. The aim of this study was to investigate the age-stratified seropositivity rates of HPIV types 1-4 among children in Korea. These data will be useful to determine vaccine requirements. This study included 245 participants categorized into four age groups: 6-11 months, 1 year, 2 years, and 3-5 years. Hemagglutination inhibition (HAI) assay was used to measure the antibody titers in the serum samples of the subjects. Overall, a significantly higher seropositivity rate (68%) was observed for HPIV3 (p < 0.001), indicating the predominant circulation of this type. In the 3- to 5-year-old group, 97% of the participants displayed seropositivity for HPIV3, suggesting that most Korean children acquire HPIV3 infection by the age of 5 years. The seropositivity rate for HPIV3 increased with age (p < 0.001); a prompt rise was observed between the 6-11 months age group and the 1-year age group. The seropositivity rates of HPIV1, HPIV2, and HPIV4 were found to increase with age (p < 0.001), with a marked increase recorded after the age of 2 years. HPIV1, HPIV2, and HPIV4 tended to infect children later than HPIV3. Older children showed high antibody titer ranges for HPIV3 (p < 0.001), suggesting that children experience multiple HPIV3 infections. An increasing trend of HPIV4 seropositivity rates with age was observed and this was comparable to theHPIV1 and HPIV2 seropositivity rates, indicating that its incidence may have been underestimated. To reduce HPIV infection, the administration of a HPIV3 vaccine to children 1 year of age is likely to be the most effective option.

Association of Nutrient Intakes with Cognitive Function in Koreans Aged 50 years and Older.

This study attempted to investigate whether nutrient and food intake were related with mild cognitive impairment (MCI) in adults and elderly over 50 years of age in Korea. Questionnaires and anthropometric measurements were conducted on general aspects of the research, and food frequency questionnaires (FFQs) were conducted to determine nutritional status. The relative theta power (RTP) through electroencephalography (EEG) measurements, neurocognitive function test (NFT; CNS Vital Signs), and cognitive function was measured. The MCI group consumed significantly lower C18:4, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) among the N-3 fatty acids, N-6 fatty acids dihomo-γ-linolenic acid (DGLA), mono unsaturated fatty acids, C22:1, biotin, vitamin D in the nutrients, and sweet potato (12.35g/day, p = 0.015), mackerel (3.38g/day, p = 0.017), mandarin orange (p = 0.016), persimmon (p = 0.013) and apple (p = 0.023) in the food than the normal group did. And the MCI group consumed salted fish (3.14g/day, p = 0.041) and ice-cream (5.01g/day, p = 0.050) at a significantly higher level. Delayed verbal score, delayed visual score, and verbal memory score of the NFT and RTP values of the prefrontal cortex among the EEGs were significantly lower in the MCI group compared to those in the normal group. From this study, we found that nutrient and food intake are closely related to MCI in Korean aged 50 years and older, but more human studies are needed to verify these findings.

Is Osteosarcoma between the Two Peak Ages Different?

Background: Unlike two known peak age groups (10 - 14 and older than 65 years of age), there was relatively scant attention in osteosarcoma patients between them, and previous reports had analyzed other than Asians. Therefore we conducted this study with Korean patients and focused on 20 - 40 years of age, then investigated age-specific or race-specific meaningful outcomes. Materials and Methods: 379 patients who were newly diagnosed as osteosarcoma in two Korean major cancer hospitals from September 1986 to July 2015 with more than 2-year follow-up were retrospectively studied. There were 290 patients with 20 - 40 years of age, 60 patients aged 19 or younger, and 29 patients aged 41 or older. Age at diagnosis, gender, location of primary lesion, metastasis at diagnosis, histologic subtypes, histologic response were analyzed as prognostic factors by overall survival (OS) and event-free survival (EFS) rates. Results: Primary pelvic lesion and poor histologic response were significantly unfavorable prognostic factors, but not age-specific. However, proportion of metastasis at diagnosis was significantly highest in 20 - 40 years of age group. For the age at diagnosis, older patients presented poorer 5-year OS and EFS rates, but for 10-year, 20 - 40 years of age group showed unusually better prognosis than younger age’s, with statistic significance in OS rates but not in EFS rates. Conclusion: Osteosarcoma patients with 20 - 40 years of age in Korea presented relatively better prognosis after longer-term 10-year despite their late diagnosis causing more metastasis at diagnosis, which emphasized expedite diagnosis and appropriate treatment to expect much better prognosis than peak age groups.

A nationwide analysis of intensive care unit admissions, 2009–2014 – The Korean ICU National Data (KIND) study

PurposeTo evaluate unbiased information on the characteristics, procedures, and outcomes of intensive care unit (ICU) admissions in a long-term nationwide study. Materials and methodsCohort study of all ICU admissions in patients >18years of age in Korea between August 1, 2009 and September 30, 2014 (1,553,673 ICU admissions in 1,265,509 patients). ResultsFrom August 2009 to September 2014, the age-standardized ICU admission rate was 744.6 per 100,000 person-years (869.5 per 100,000 person-years in men and 622.0 per 100,000 person-years in women). The overall in-hospital mortality was 13.8% (14.1% in men and 13.5% in women). Among all Koreans, the ICU mortality rate was 102.9 per 100,000 person-years (122.5 per 100,000 person years in men and 83.8 per 100,000 person years in women). The median ICU and hospital length of stay were 4 and 13days, respectively. The median cost per ICU admission was $5051, which increased steadily over the study period. There were marked differences by gender in ICU admission rates, aggressive support, and outcomes. ConclusionsOur study identified increasing trends in ICU admissions and utilization of advance life support systems that add to the burden of care in a developed society.