Association between ambient fine particulate matter and seasonal variation in acute myocardial infarction morbidity

Abstract

TPS 683: Short-term health effects of air pollutants 2, Exhibition Hall, Ground floor, August 28, 2019, 3:00 PM - 4:30 PM Background/Aim: Environmental factors may play a role in the development of cardiovascular diseases and some studies have shown that ambient air pollution is associated with the myocardial infarction. This study was designed to investigate the impact of ambient air pollution on acute myocardial infarction (AMI) among adult over 20 years of age in Korea by using the data from the Korean National Health Information Database (KNHID) Methods: This study used the nationwide, population-based database from the KNHID collected between 2002 and 2015. Data analysis was performed from January 1, 2005 to December 31, 2014 since the ambient fine particulate matter (PM2.5) monitoring data from Seoul Research Institute of Public Health and Environment were available in these periods. Data on 197,940 AMI case counts in Seoul were collected. Meteorological data were collected from the Korea Meteorological Administration (KMA). We used the Poisson regression analysis adjusted for calendar time, current-day temperature, dew-point temperature, relative humidity to explore the association between PM2.5 and AMI. Results: The mean daily PM2.5 concentrations was 25.9μg/m3 with a range from 23.0 to 544μg/m3. In the Poisson regression analysis of PM2.5, the models with lag structures of lag 0 day and 2-day average of lags 0 and 1 (lag01) showed significant association with AMI (RR:1.017, CI:1.008-1.025 for lag0, RR:1.014, CI: 1.005-1.023 for lag01). There were dose-response relationships of PM2.5 concentration and AMI at lag0 and lag01. In the stratified analysis carried out in the cold season (October-April) and warm season (May-September) showed the significant lag 0 effect for AMI cases in the cold season only. Conclusions: In conclusions, our results have demonstrated that the PM2.5 concentration was significantly associated with AMI morbidity at lag 0 in Seoul, Korea. This increased risk was also observed in cold season and future prospective studies are needed to determine the causal association.