Abstract
Background/Aim: Previous studies have suggested that the short-term ambient air pollution and temperature are associated with myocardial infarction. In this study, we aimed to conduct a time-series analysis to assess the impact of fine particulate matter (PM2.5) and temperature on acute myocardial infarction (AMI) among adults over 20 years of age in Korea by using the data from the Korean National Health Information Database (KNHID). Methods: The daily data of 192,567 AMI cases in Seoul were collected from the nationwide, population-based KNHID from 2005 to 2014. The monitoring data of ambient PM2.5 from the Seoul Research Institute of Public Health and Environment were also collected. A generalized additive model (GAM) that allowed for a quasi-Poisson distribution was used to analyze the effects of PM2.5 and temperature on the incidence of AMI. Results: The models with PM2.5 lag structures of lag 0 and 2-day averages of lag 0 and 1 (lag 01) showed significant associations with AMI (Relative risk [RR]: 1.011, CI: 1.003–1.020 for lag 0, RR: 1.010, CI: 1.000–1.020 for lag 01) after adjusting the covariates. Stratification analysis conducted in the cold season (October–April) and the warm season (May–September) showed a significant lag 0 effect for AMI cases in the cold season only. Conclusions: In conclusion, acute exposure to PM2.5 was significantly associated with AMI morbidity at lag 0 in Seoul, Korea. This increased risk was also observed at low temperatures.
Highlights
Acute myocardial infarction (AMI) is a leading cause of death worldwide [1,2]
We explored the effect of three daily temperatures on acute myocardial infarction (AMI) morbidity in adults
This study suggests there is evidence of an association between PM2.5 concentration and AMI morbidity in adults at lag 0 and lag 01 in Seoul, Korea
Summary
Acute myocardial infarction (AMI) is a leading cause of death worldwide [1,2]. The incidence of AMI in Korea has increased over the last few decades [3,4]. It is important to prevent the occurrence of AMI and identify the risk factors of AMI. Many environmental factors have been suggested as risk factors for AMI. Air pollution has been repeatedly associated with increased risks of hospital admissions and deaths due to cardiovascular disease. Particulate matter (PM) has been identified as a risk factor for cardiovascular disease in studies performed throughout the industrialized world [5,6,7]. Air pollution is increasing as urbanization and industrialization processes expand worldwide
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