Abstract
Background: Unlike two known peak age groups (10 - 14 and older than 65 years of age), there was relatively scant attention in osteosarcoma patients between them, and previous reports had analyzed other than Asians. Therefore we conducted this study with Korean patients and focused on 20 - 40 years of age, then investigated age-specific or race-specific meaningful outcomes. Materials and Methods: 379 patients who were newly diagnosed as osteosarcoma in two Korean major cancer hospitals from September 1986 to July 2015 with more than 2-year follow-up were retrospectively studied. There were 290 patients with 20 - 40 years of age, 60 patients aged 19 or younger, and 29 patients aged 41 or older. Age at diagnosis, gender, location of primary lesion, metastasis at diagnosis, histologic subtypes, histologic response were analyzed as prognostic factors by overall survival (OS) and event-free survival (EFS) rates. Results: Primary pelvic lesion and poor histologic response were significantly unfavorable prognostic factors, but not age-specific. However, proportion of metastasis at diagnosis was significantly highest in 20 - 40 years of age group. For the age at diagnosis, older patients presented poorer 5-year OS and EFS rates, but for 10-year, 20 - 40 years of age group showed unusually better prognosis than younger age’s, with statistic significance in OS rates but not in EFS rates. Conclusion: Osteosarcoma patients with 20 - 40 years of age in Korea presented relatively better prognosis after longer-term 10-year despite their late diagnosis causing more metastasis at diagnosis, which emphasized expedite diagnosis and appropriate treatment to expect much better prognosis than peak age groups.
Highlights
Osteosarcoma has a bimodal age distribution; the first peak is in the 10 - 14 years of age group which coincides with pubertal growth spurts, and the second peak is in adults older than 65 years of age who are more likely to represent a second malignancy, commonly related to Paget’s disease [1]
For 10-year overall survival (OS) and event-free survival (EFS) rates, group B characteristically showed better results compared to other age groups, especially significant in 10-year OS (p = 0.012), but not statistically significant in 10-year EFS (p = 0.081) (Table 1, Table 2)
Two-center study we found that presence of metastasis at diagnosis, primary lesion at pelvis, and poor histologic response were significant unfavorable prognostic factors in the patients with osteosarcoma
Summary
Osteosarcoma has a bimodal age distribution; the first peak is in the 10 - 14 years of age group which coincides with pubertal growth spurts, and the second peak is in adults older than 65 years of age who are more likely to represent a second malignancy, commonly related to Paget’s disease [1]. Between these two peaks of age, 20 - 40 years of age group is generally considered as “young adults” [2]. Unlike two known peak age groups (10 - 14 and older than 65 years of age), there was relatively scant attention in osteosarcoma patients between them, and previous reports had analyzed other than Asians. Conclusion: Osteosarcoma patients with 20 - 40 years of age in Korea presented relatively better prognosis after longer-term 10-year despite their late diagnosis causing more metastasis at diagnosis, which emphasized expedite diagnosis and appropriate treatment to expect much better prognosis than peak age groups
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
