Y-shaped Configuration Research Articles

Impact of double stent retriever configuration on first-pass effect in stroke: a multicenter study

BackgroundEfficient recanalization of occluded cerebral arteries is crucial in the treatment of acute ischemic stroke. Double stent retrievers have shown the potential to enhance the rates of recanalization on the...

Enhancing the Concentration Capability of Nonsupported Electrically Driven Liquid-Phase Microextraction through Programmable Flow Using an All-In-One 3D-Printed Optosensor: A Proof of Concept.

A versatile millifluidic 3D-printed inverted Y-shaped unit (3D-YSU) was prototyped to ameliorate the concentration capability of nonsupported microelectromembrane extraction (μ-EME), exploiting optosensing detection for real-time monitoring of the enriched acceptor phase (AP). Continuous forward-flow and stop-and-go flow modes of the donor phase (DP) were implemented via an automatic programmable-flow system to disrupt the electrical double layer generated at the DP/organic phase (OP) interface while replenishing the potentially depleted layers of analyte in DP. To further improve the enrichment factor (EF), the organic holding section of the OP/AP channel was bifurcated to increase the interfacial contact area between the DP and the OP. Exploiting the synergistic assets of (i) the continuous forward-flow of DP (1050 μL), (ii) the unique 3D-printed cone-shaped pentagon cross-sectional geometry of the OP/AP channel, (iii) the bifurcation of the OP that creates an inverted Y-shape configuration, and (iv) the in situ optosensing of the AP, a ca. 24 EF was obtained for a 20 min extraction using methylene blue (MB) as a model analyte. The 3D-YSU was leveraged for the unsupervised μ-EME and the determination of MB in textile dye and urban wastewater samples, with relative recoveries ≥88%. This is the first work toward analyte preconcentration in μ-EME with in situ optosensing of the resulting extracts using 3D-printed millifluidic platforms.

Configuration of Carbonatite Constrained in Preintrusion Transpositional Foliation in the Bayan Obo Giant Rare Earth Element Deposit, China

Abstract The Bayan Obo ore deposit is the largest rare earth element (REE) deposit in the world and has been assumed to be hosted in dolomite that was folded in a syncline. This has been challenged by results from drill holes and low-resistivity, controlled-source audio-frequency magnetotellurics (CSAMT) survey. In this paper, we present structural analysis of clastic sedimentary rocks from around the deposit, their relationship with carbonatite, and the orientations of the carbonatite bodies and dikes to constrain the possible configuration of carbonatite. Clastic sedimentary rocks underwent mylonitic deformation to slate, metasandstone, and metaconglomerate, displaying dramatic changes of thickness along strike. Slates locally preserve intrafolial folds and hook folds bounded by foliations; metasandstones have parallel layers of recrystallized and preferred-orientated quartz aggregations; metaconglomerates contain flattened pebbles with Flinn k values of 0.01 to 0.05 and 0. The above structures and foliations were crosscut and intruded by carbonatite and associated fenite, demonstrating preintrusion transposition of original bedding to steep foliation. Preintrusion foliation provides zones of weakness that were exploited by upwelling of carbonatite magma. Northeast-SW–striking left-stepping en echelon carbonatite dikes and E-W–striking carbonatite bodies indicate that the carbonatite was emplaced in a sinistral transtensional zone. The northern and southern segments of the carbonatite bodies are parallel to the steep foliation at shallow depths and merge together at depth, constraining a Y-shaped configuration, consistent with the low resistivity result of the CSAMT survey. The newly recognized Y-shaped morphology indicates that the carbonatite extends deeper than 1,775.4 m, more than twice the previously inferred maximum depth of the syncline model, and contributes to a significant >1.78 times increase in global potential RE2O3 resources than previously estimated in 2021.

Correlations of baryon and charge stopping in heavy ion collisions* *Supported in part by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB34030000) and the National Key Research and Development Program of China (2022YFA1604900), the U.S. DOE Office of Science365 under contract (DE-SC0012704, DE-FG02-10ER41666, DE-AC02-98CH10886)

Baryon numbers are theorized to be carried by valence quarks in the standard QCD picture of the baryon structure. Another theory proposed an alternative baryon number carrier, a non-perturbative Y-shaped configuration of the gluon field, called the baryon junction in the 1970s. However, neither of these theories has been verified experimentally. Recently, searching for the baryon junction by investigating the correlation of net-charge and net-baryon yields at midrapidity in heavy-ion collisions has been suggested. This paper presents studies of such correlations in collisions of various heavy ions from oxygen to uranium with the UrQMD Monte Carlo model. The UrQMD model implements valence quark transport as the primary means of charge and baryon stopping at midrapidity. Detailed studies are also conducted for isobaric + and + collisions. We found a universal trend of charge stopping with respect to baryon stopping and discovered that the charge stopping is always greater than the baryon stopping. This study provides a model baseline in valence quark transport for what is expected in net-charge and net-baryon yields at the midrapidity of relativistic heavy-ion collisions.

A nanozipper structured efficient FRET probe for ratiometric detection of ATP based on target-induced cycling amplification

In the realm of disease diagnostics and prognostics, accurate quantification of adenosine triphosphate (ATP) has become crucial, as the intricate interplay between ATP and cellular metabolism is a fundamental factor in the pathogenesis and progression of many pathological conditions. Herein, a ratiometric fluorescence DNA nanozipper is developed, which enables highly sensitive detection of ATP by employing catalytic hairpin assembly. This innovative approach utilizes target-induced conformational changes in the nanozipper structure to tune the distance between the carboxyfluorescein as donor and tetramethylrhodamine as acceptor around the Förster radius, thereby enhancing the efficiency of fluorescence resonance energy transfer (FRET). In the state of nanozipper tension, the rigid and steric hindrance Y-shaped configuration leads to a considerable distance between two fluorophores, resulting in FRET low efficiency. However, the presence of ATP triggers allosteric configuration of the DNA nanozipper, switching the nanozipper to a relaxed state, which results in a visible fluorescent ratiometric signal. The sensing strategy exhibits a linear response to ATP concentrations in the range of 30 − 600 nM and can detect concentrations as low as 9.6 nM. Additionally, this detection method introduces a novel idea for the design of efficient FRET probes and demonstrates promising application potential in biological samples.

Engineered Branching Peptide as Dual-Functional Antifouling and Recognition Probe: Toward a Dual-Photoelectrode Protein Biosensor with High Accuracy.

The building of practical biosensors that have anti-interference abilities against biofouling of nonspecific proteins and biooxidation of reducing agents in actual biological matrixes remains a great challenge. Herein, a robust photoelectrochemical (PEC) biosensor capable of accurate detection in human serum was pioneered through the integration of a new engineered branching peptide (EBP) into a synergetic dual-photoelectrode system. The synergetic dual-photoelectrode system involved the tandem connection of a C3N4/TiO2 photoanode and a AuPt/PANI photocathode, while the EBP as a dual-functional antifouling and recognition probe featured an inverted Y-shaped configuration with one recognition backbone and two antifouling branches. Such an EBP enables a simple procedure for electrode modification and an enhanced antifouling nature compared to a regular linear peptide (LP), as theoretically supported by the results from molecular dynamics simulations. The as-developed PEC biosensor had a higher photocurrent response and a good antioxidation property inherited from the photoanode and photocathode, respectively. Targeting the model protein biomarker of cardiac troponin I (cTnI), this biosensor achieved good performances in terms of high sensitivity, specificity, and anti-interference.

Total Autologous Fascia Lata Sacrocolpopexy for Treatment of Pelvic Organ Prolapse: Experience in Thirty-Four Patients

ObjectiveTo develop a technique for open/robotic sacrocolpopexy using autologous fascia lata autograft. We report our experience in our first 34 patients. MethodsThe operation utilizes a 4-5-cm x 15-18-cm piece of fascia lata harvested through a 3-4-inch lateral upper thigh incision. The graft is configured into a traditional Y-shaped configuration using CV-2 Goretex sutures and is used to perform sacrocolpopexy. Patients were followed by history and physical, POP-Q scores, and symptoms related to thigh harvest including visual analog pain (VAP) scores. Treatment failure was defined as symptomatic pelvic organ prolapse (POP) involving apical descent. ResultsAutologous fascia lata sacrocolpopexy was performed on 34 patients with a mean age of 62. Mean follow-up was 13 months (range 2-42). Thirteen cases were open sacrocolpopexies, and 21 were robotic. Concurrent procedures included hysterectomy (9), vaginal mesh excision (7), bowel resection and rectopexy (5), and autologous sling (5). POP symptoms resolved in all 34 patients, and there were no treatment failures. The overwhelming majority of harvest site issues were minor and managed expectantly. Mean VAP score at the harvest site was 0.4 (range 0-3). Three patients developed non-bothersome thigh bulges. One patient developed a harvest site seroma. Twelve patients reported mild, non-bothersome harvest site paresthesias. No thromboembolic events occurred. ConclusionAutologous fascia lata sacrocolpopexy is an efficacious treatment for patients who desire non-mesh POP repair. Most harvest site issues are minor and typically resolve with expectant management alone. Continued follow-up of this series is ongoing to determine long-term success of this operation.

Electrochemical polymerization of D-A-D type monomers consisting of triphenylamine and benzo[1,2-b:4,5-b′]dipyrazine units for multicolor electrochromism

We developed four donor-acceptor-donor (D-A-D) type monomers (YQ1 ∼ YQ4) with Y-shape configuration consisting of triphenylamine and benzo[1,2-b:4,5-b′]dipyrazine moities, which were further polymerized via electrochemical polymerization for electrochromic applications. The monomers were synthesized facilely from benzene-1,2,4,5-tetraamine tetrahydrochloride by sequential condensation reactions with diketones. The optical properties of these polymers in neutral states can be tuned by variation of the additional substituents on the electron acceptor parts. All these polymers (PYQ1 ∼ PYQ4) exhibited multicolor electrochromism, and appeared similar green color at their second coloration states. Moreover, polymers PYQ1 and PYQ2 with two twisted substituents on the acceptor part showed superior electrochromic performance than the anologues PYQ3 and PYQ4 consisting fused electron acceptor moities with high coplanarity, involving faster response speed, and higher coloration efficiency, which demonstrated that the molecular configuration of monomer was crucial for efficient electrochromic performance.

Role of Ultrasonography in the Evaluation of Normal Developmental Pattern of Fetal Cerebral Sulci Between 18 and 32 Weeks of Gestational Age.

BackgroundBrain development is a crucial process of intrauterine life and can be readily visualized on ultrasonography. This study aims to visualize developmental patterns of various fetal cerebral sulci using ultrasonography between 18 and 32 weeks of gestation. Sulci are best visualized on images that are taken perpendicular to their expected course of development. Initially, they appear as small dot/dimple on the brain surface and later develop into a V-shaped indentation and finally deepen to form notch and echogenic line into the brain forming a Y-shaped configuration.Material and methodsThis was a cross-sectional observational study conducted on 241 antenatal mothers with a singleton pregnancy between 18 and 32 weeks of gestational age. Demographic and clinical data were obtained. Ultrasonography was performed using PHILIPS EPIQ 5, a curvilinear probe of frequency 2-5MHz. Sulci/fissures that are reported to appear early on anatomical studies were evaluated, specifically the parieto-occipital fissure, calcarine fissure, cingulate sulci, insula/Sylvian fissure, and convexity sulci. Comparison of the categorical outcomes was performed between study groups using the chi-square test. A p-value of <0.05 was considered statistically significant.ResultsThe study included 241 participants. The mean age of antenatal mothers was 24.09 ± 4.13 years, and the mean fetal gestational age was 24.99 ± 4.13 weeks. Parieto-occipital fissure was the first fissure to develop and was present as a V-shaped indentation at 18 weeks and as a Y-shaped configuration by 21-22 weeks. Calcarine fissure was the next fissure to appear; it appeared as a dot by 18 weeks and developed into a V-shaped indentation by 20 weeks and as a Y-shaped configuration by 23 weeks. All fissures except cingulate sulci had appeared by 20 weeks, and calcarine sulci appeared later in the gestation by 21 weeks. Sylvian fissure initially appeared as a smooth surface and later underwent operculization to form obtuse and acute angulations with the adjacent temporal lobe by 20 and 24 weeks, respectively. Convexity sulci appeared later in gestation, beyond 25-26 weeks.ConclusionsUltrasonography, which is the commonest modality used in antenatal assessment of the fetus, can also be used to identify, familiarize, and provide a standard reference to assess normality of fetal sulcations. Neuronal migration disorders result in a wide spectrum of malformations of cortical development whose clinical manifestations include severe psychomotor retardation, developmental delays, motor deficits, seizures, and failure to thrive. Knowledge of normal development patterns of fetal cerebral sulci helps in early suspicion and detection of these cortical malformations, when present.

A Dual-Arm Concentric-Tube Robot System for Transnasal Surgery

This paper proposes a novel dual-arm concentric-tube robot (CTR) system in transnasal minimally-invasive surgery (MIS) of nasopharyngeal carcinoma (NPC) resection. Firstly, the design of the robot system is described including the manipulators that consist of NiTi tubes, the modular actuation unit modules, the bending unit constraining the robot into a Y-shaped configuration, and optimization of the Y-shaped transmission system. Then, the kinematic model of CTR is introduced and a bimanual teleoperation approach is presented based on it. Finally, a performance test experiment and a tumor resection experiment have been successfully carried out based on the robot prototype, which show the feasibility of the proposed dual-arm CTR system in transnasal MIS of NPC resection.

Quadruple, 4-segment, triple sector "Y-shaped stents" in complex hilar cholangiocarcinoma after cholangitis from plastic stents.

Video 1Video showing successful placement of 4 uncovered self-expanding metal stents in a stent-in-stent, Y-shaped configuration for cholangitis from plastic stents in a patient with unresectable cholangiocarcinoma.

The Effect of Y-Shaped Brace Configuration on Its Seismic Behavior

The Effect of Y-Shaped Brace Configuration on Its Seismic Behavior

Nucleotide sequences of the infectious DNA clones of two mink enteritis virus isolates exhibit the diversity of the terminal palindromic sequences and predicted secondary structures

In this study, the infectious RF-DNA clones of two mink enteritis viruses, MEV-SD1 and MEV-SD7, were constructed, which generated progeny virions and seemed to contain an almost or completely full-length genome. The genomes of MEV-SD1 and MEV-SD7 were 5162 bp and 5113 bp in length, respectively. The genomic organizations of MEV-SD1 and MEV-SD7 were similar to that of the other carnivore parvoviruses. The 3′-UTR of the virion strand of MEV-SD1 and MEV-SD7 were 311 bp and 313 bp in length, respectively, containing a 208 bp palindromic sequence assuming Y-shaped configurations. Interestingly, the difference of the 3′ palindromic sequences between MEV-SD1 and MEV-SD7 resulted in the orientation inversion of the hairpin ears. And the 5′-UTRs of MEV-SD1 and MEV-SD7 were 582 bp and 531 bp, respectively, containing a 198 bp palindromic sequence assuming U-shaped configurations, a triplet mismatch (5′-TAC-3′) in the center of the duplex stem and a triplet mismatch (5′-AGA-3′) forming a small asymmetric bubble. The findings demonstrated that the genomic termini of the carnivore parvoviruses showed the diversity in length, base composition, and predicted secondary structure.

Self-assembled rhomboidal ammonia monolayer confined in two vertically stacked graphene oxide/graphene nanosheets.

Confined water molecules have attracted widespread research interest due to their versatile phase behaviors. Ammonia (NH3, isoelectronic with water) molecules are also expected to realize the delicate self-assembled hydrogen-bonded network like water in confinement. Here, the structures and phase behavior of NH3 monolayers confined in two structurally symmetrical graphene oxide (GO) or graphene (G) nanosheets are investigated using first-principles calculations and ab initio molecular dynamics simulations. A highly ordered new rhomboidal phase with all NH3 molecules adopting a Y-shaped configuration, in which one N-H bond is parallel to the confining planes and two other N-H bonds point to the top/bottom GO/G layers, respectively, was discovered at low temperature, resulting from the symmetrical confinement and subtle interlayer/intermolecular interactions. Remarkably, this new phase is so stable that a quite large strain is needed to destroy it. At room temperature, these NH3 monolayers behave like a liquid. These rhomboidal NH3 monolayers confined in GO/G nanosheets not only offer diverse hydrogen-bonded networks but also possess potential piezoelectricity for future device applications.

Characterization of a new spiral nematode, Helicotylenchus asiaticus n. sp., and three known species from Korea; with comments on the validity of Helicotylenchus microlobus Perry in Perry, Darling &amp; Thorne, 1959

A new spiral nematode Helicotylenchus asiaticus n. sp., recovered from sandy rhizosphere of Poa pratensis from Korea, is characterized based on integrative taxonomy, considering both morphological and molecular phylogenetic inferences from analyses of the 28S-rRNA and ITS-rRNA gene sequences. Additionally, H. caudatus is characterized for the first time outside its type locality; notes on the taxonomic status of H. microlobus are stated, and the existence of H. dihystera in Korea is molecularly confirmed. The new species is characterized by a lip region not offset; hemispherical, bearing 4–5 annuli; stylet knobs sloping posteriorly, rarely anteriorly flattened; spermatheca, offset and filled with sperms; incisures of the lateral field areolated in pharyngeal region, with incomplete areolation in the tail region; inner incisures usually distally modified into a u-shape or y-shaped configuration; phasmids postanal, situated at 3–8 annuli posterior to anus level; tail conical, bearing 8–15 annuli, ending in a rounded to pointed extremity; and males abundant. The new species is morphologically similar to H. erythrinae, H. californicus, H. electropicus, H. tropicus, H. conicus, H. elegans, H. interrogativus, H. saxeus, H. certus and H. silvaticus but differs from all, either by lip region shape, stylet knob shape, sperm filled spermatheca, phasmid position, tail termini shape and (or) presence of males. Sequence data analyses from amplified regions suggest that Helicotylenchus asiaticus n. sp. is a sister species to unidentified Helicotylenchus sp. From Korea.

Radiographic Assessment of Nasopalatine Canal Using Cone Beam Computed Tomography.

To assess the morphology of nasopalatine canal and to determine the variation of this canal in correlations to age and gender in Iraqi sample using cone beam computed tomography (CBCT). A total of 200 requested CBCT images for nasopalatine canal evaluation before dental implantology at the anterior maxillary region. The morphology of canals was classified into 3 groups in coronal cross-sections. The effects of age and gender were also measured. The study comprised 100 males and 100 females with mean age of 30.64 ± 9.46 years. Most of the cases showed Y-shape configuration type III 43.5% followed by type I single canal 35.5%, and type II with 2 parallel canals 21%, CONCLUSION:: Due to the wide variation in the morphology of nasopalatine canals, it is highly recommended to perform CBCT evaluation to the anterior maxilla before dental implantology in order to prevent any damage to the neurovascular bundle.

Assesment of accessory branches of canalis sinuosus on CBCT images.

Background The aim of this study is to describe the presence, to reveal the frequency and characteristics of accessory canals (ACs) of the canalis sinuosus (CS) by cone beam computed tomography (CBCT). Material and Methods A total of 326 CBCT examinations were scanned retrospectively. The anatomical views were evaluated on sagittal, axial, coronal and cross sectional imaging. The following parameters were recorded: age, sex, presence or absence of ACs, location in relation to the adjacent teeth and distance to the nasal cavity floor (NCF), alveolar ridge crest (ARC) and buccal cortical bone (BCB), and incisive canal. All the collected data were statistically analyzed. Results 113 patients (34,7%); presented ACs in total 214 foramina of the sample. There were no statistically significant changes in the presence of ACs regarding age groups excluding 80-89 years. But there is a statistically significant difference regarding the frequency of ACs and the gender. The prevalence for male patients was higher than female patients. Curved-shape configuration of CS prevalence is found as 69,15%. The prevalence of vertical tracing is 26,16% and Y-shape configuration of CS prevalence is 4,67%. Diameter of the foramens of the CS branches was 1.30 mm. The mean distance of the AC to the NCF, BCB, and ARC were found 13,83 mm, 6,60 mm and 5,32 mm, respectively. Conclusions In the anterior palatal region, ACs are mostly related to CS’s branches. So; knowing the course of CS branches in surgical planning and radiographic evaluations in this region is extremely important for preventing complications and avoiding misdiagnosis. Key words:Anterior superior alveolar nerve, canalis sinuosus, maxilla.

A topological analysis of growth in the Zurich road network

The functioning of a city depends upon physical structures and services. Over time, a city evolves and the layout of its infrastructure is altered, providing a new arrangement of services for citizens. When designing road infrastructure, planners usually add or change existing roads, looking only at local consequences and ignoring the effects on the whole system. This results in an infrastructure that is developed without a clear understanding of how those alterations affect the global topology. We studied the development of road infrastructure in Zurich, Switzerland, modelled as a network. Our objectives were to 1) assess how non-spatial network topological metrics can identify changes in infrastructure over time and 2) determine any patterns of change in the spatial distribution of those metrics. We analyzed three types of betweenness centrality (BC) metrics with different weighting methods that depended upon structural properties, distance, and population distribution within the urban area. The study resulted in four main findings. First, the number of nodes and edges, together with the network diameter characterized the non-spatial aspect of development. Second, traditional connectivity metrics (alpha, beta, gamma indices) did not yield any changes in time due to their dependence on the average degree, which remained quite constant in infrastructure networks. Third, areas of high BC extended from 1955 to 2012 into a Y-shaped configuration, driven by the development of the main overarching national freeway system. Closeness centrality results show similar patterns. Fourth, the distribution of the 1955 normalized betweenness centrality values transformed into a more heavy-tail distribution in 2012, which implicated that the most critical nodes became even more critical. Future work will enhance this analysis by using more realistic assumptions and incorporating traffic survey data.

Mechanics of the Formation, Interaction, and Evolution of Membrane Tubular Structures

Membrane nanotubes, also known as membrane tethers, play important functional roles in many cellular processes, such as trafficking and signaling. Although considerable progresses have been made in understanding the physics regulating the mechanical behaviors of individual membrane nanotubes, relatively little is known about the formation of multiple membrane nanotubes due to the rapid occurring process involving strong cooperative effects and complex configurational transitions. By exerting a pair of external extraction upon two separate membrane regions, here, we combine molecular dynamics simulations and theoretical analysis to investigate how the membrane nanotube formation and pulling behaviors are regulated by the separation between the pulling forces and how the membrane protrusions interact with each other. As the force separation increases, different membrane configurations are observed, including an individual tubular protrusion, a relatively less deformed protrusion with two nanotubes on its top forming a V shape, a Y-shaped configuration through nanotube coalescence via a zipper-like mechanism, and two weakly interacting tubular protrusions. The energy profile as a function of the separation is determined. Moreover, the directional flow of lipid molecules accompanying the membrane shape transition is analyzed. Our results provide new, to our knowledge, insights at a molecular level into the interaction between membrane protrusions and help in understanding the formation and evolution of intra- and intercellular membrane tubular networks involved in numerous cell activities.

Y-shaped and T-shaped slots in river bridge piers as scour countermeasures

Slots in river bridge piers have proved effective at reducing foundation scour. This paper reports on 33 experiments carried out under clear-water conditions to assess the performance of Y-shaped and T-shaped slots compared with commonly used straight slots. The variables included three flow discharges, five types of slotted piers and a single pier without a slot, two slots partially embedded in the river bed and non-embedded slots. The scour contours and longitudinal and transverse scour profiles were measured. It was observed that, for the Y-shaped slots, the size of the downstream scour was reduced by decreasing the angle between the downstream slot faces. The results also indicated that the Y-shaped slots were more efficient than the T-shaped slots for scour control, while slot efficiency increased with embedment depth. A maximum efficiency of 59% in scour volume reduction was obtained for the best Y-shaped configuration, compared with a 53% reduction for the straight slot. Regarding the maximum scour depth, the straight slot provided a maximum scour reduction of 38%, compared with 33% maximum reduction for the Y-shaped slot.