For environment friendly water splitting, development of highly efficient and stable oxygen evolution reaction (OER) catalyst composed of earth abundant elements is very challenging. Herein, highly efficient OER catalysts TMS@MOF-5 have been prepared by in-situ incorporation of pre-synthesized various transition metal sulfide (TMS = MnS, FeS, CoS, NiS, CuS and ZnS) nanoparticles into MOF-5. Structure, morphology and composition of prepared samples have been analyzed by powder X-ray diffraction, Fourier Transform Infrared Spectroscopy, Raman Spectroscopy, Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy, Elemental Mapping and Ultraviolet–Visible Spectroscopy. OER activity of all these samples was determined by coating them on Ni-foam to form TMS@MOF-5/NF as working electrode through cyclic voltammetry. Among all the samples, NiS@MOF-5/NF exhibited excellent stability and OER catalytic activity as it required just 174 mV overpotential to achieve the 10mAcm−2current density, which is better than many other 3d transition metal based and Ni-based OER catalysts. Present study provides new way to design more efficient Ni-based catalysts for electrochemical water splitting applications.