Commercial detector-grade cadmium zinc telluride (CZT) crystals still suffer from various types of extended defects, e.g., dislocations, micro-grains, grain boundaries, and Te-rich secondary phases. Most of these defects cannot readily be identified and characterized using conventional techniques, though they are believed to be the dominant factor causing non-uniformity in the detector response. In this work, we revealed and characterized these secondary-phase defects in CZT crystals by employing multiple advanced techniques, e.g. X-ray diffraction topography, micro-scale X-ray response mapping, chemical etching and infrared microscopy. We then evaluate the detector performance of the crystals by recording high spatial-resolution raster scans of the charge collection and spectral response. We directly correlated the influence of the secondary-phase defects on the performance of the detector responses. The experimental results exhibit clear evidence of the undesirable effects of extended defects on the performance of commercial CZT radiation detectors.