Objective. The objective of the present article is analysis of features and probability of manifestation of national security risks in the conditions of globalization. Methods. The following methods and techniques of cognition were used in the research process: theoretical generalization and comparison, analysis and synthesis, induction and deduction, generalization and systematization. Results. It is established that national security should be understood as the ability of the State to respond effectively to internal and external challenges, to ensure the realisation of national interests in the short, medium and long term, using the available economic potential and the potential of force. It is determined that the concept of "national security" is closely related to the concepts of "national interests" and "threats and challenges". It is determined that in the context of increasing globalisation, the level of national security is increasingly determined not only by endogenous but also by exogenous factors. It is substantiated that despite the fact that the level of global risks of countries is closely correlated with the level of their involvement in globalisation processes, it is not the dominant determinant of the country's level of national security, since it is determined not only and not so much by the presence of threats and risks as by the effectiveness of the country's response to existing and potential threats, the effectiveness of the "challenge-response" system - the system of national resilience. It is established that the effectiveness of the "challenge-response" system - the system of national resilience to effectively respond to external threats and risks is determined by: the effectiveness of public administration; the level of development of public-private-social partnership (the level of development of relations between business and government, as well as society); the level of trust of society in general and business in particular in government and state institutions; the level of corruption; the level of satisfaction of society and business with public services, etc. On the basis of a thorough analysis of global risks in 2010-2023 (based on the World Economic Forum data), the main systemic risks to the security of the world economic system and humanity, national security in the twenty-first century were identified, with the time interval of their manifestation determined; the peculiarities of transformation of the nature of global risks (in 2010-2023, social and environmental risks became more important).