The aim of the article is to show the importance of methodological foundations in the relationship between art and medicine, whose source is the sacral core of the syncretic complex of primitive society, which includes the principles of harmony and beauty, the use of which makes it possible to have a therapeutic effect on human health under conditions where modern art of the West and East is characterized by the use of many new technologies that cancel the lines between abstract thinking and artistic activity. All this is directly related to the functioning of medicine III, which combines the methods of Eastern and technology and the instrument base of Western medicine, as well as new concepts and paradigms in the context of such trends of the modern world as aestheticization and technization. Materials and methods. This article uses the followingg theoretical tools: the idea by C. Jung, quite widely used in modern research, that a person’s psychological impulses (archetypes) lie dormant in his collective unconscious (self), which contains the golden ratio; a new approach to the relationship between art and medicine, when the Universe is a masterpiece of Baroque art, and medicine has a quantum character; the paradigm of the fractal nature of the world; the concept of the relationship between the synergetics of the human brain and the synergetics of art; the relationship between art and medicine in the aspect of disaster theory; the paradigms of “integration of the model of healing and healing according the traditions of the East and West; mythological and ritual source of the unity of arts and medicine; the model of digital art and human consciousness. The analytical psychology of K. Jung was chosen as the methodology and logic of scientific research into the relationship between art and medicine, which makes it possible to show the significance of their deep connections in adapting to the complex world of uncertainty and extremity. Results. For the first time in philosophical literature, the philosophical and methodological significance of the relationship between art and medicine is shown from the position of depth psychology by C. Jung in the development of the unconscious of civilizations and cultures of our planet, which makes it possible to adequately assess the degree of their significance in the context of an increasing number of extreme situations. For the first time, a hypothesis has been put forward, according to which art therapy gives a person’s life high meaning. Conclusions. It is proposed to use methodological problems of the relationship between art and medicine based on the depth psychology by C. Jung to overcome the cultural savagery of humanity so that it can survive in the extreme situation of the modern world.