AbstractTwo major challenges in the modern world are ensuring food security and using sustainability in limited areas, in the face of climate change and population growth. It is aimed to raise awareness on the importance of working from a multidisciplinary perspective, together with developing technology and science, in solving current problems/troubles, and that the simultaneous use of modern bio-based technologies with innovative techniques will ensure an effective role in overcoming many difficulties that future generations will face, as well as sustainability can be achieved. The review provides a detailed systematic review and analysis of the mutually supportive use of modern bio-based technologies and sustainable agricultural system technologies within the framework of this subject. The review, in which universally reliable databases were used, was carried out using information obtained from practice and approach-based articles (> 4000). The fact that the main topic has the lowest publication content in terms of "sustainability and biotechnology" according to the analysis carried out within the determined keywords indicates the need for additional research and applications and to contribute to the literature. Similar to review aim, it has also been concluded that the development of a multidisciplinary, interdisciplinary and transdisciplinary perspective that provides a comprehensive and broader focus on eliminating the deficiencies in the fields will play a major role in solving problems related to the sustainability of food safety and security. Thus, contributing to the protection of world food security should be considered as another important outcome that should not be forgotten. In short, being aware that the world, especially its resources, are not infinite and for the continuity of healthy generations, the sustainability of the world, food and agriculture, food safety and security must be meticulously protected, developed with innovative technologies and also carried a step forward by developing more effective strategies in this field of work, which is of great importance for life.
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