This study aims to examine the influence of an organization’s missions on employees’ turnover intention in the rarely studied context of social enterprises. Data collected from 236 full-time employees working for social enterprises in South Korea indicated that the negative relationship between social mission and turnover intention was mediated by the meaning of work; this mediation effect was weaker when the economic mission was stronger. The study contributes to the literature on organizational psychology (i.e., meaning of work, turnover) in the context of a new, but increasingly prevalent, organizational form—social enterprises. It also provides practical advice for managers seeking to retain and empower employees and enhance the sustainability of their social enterprises.