Abstract Indices of red blood cell (RBC) status were assessed in eight high school women cross-country runners (experimental group) six times during a competitive season (Weeks 0, 1, 2, 4, 6, and 8) and three times (Weeks 0, 1, and 3) in 11 high school women who were not runners (comparison group). The only significant preseason hematological difference between the groups was a higher RBC fragility for the runners. All blood indices for both groups were within normal ranges throughout the study. During the competitive season (Weeks 0–8), the runners had a significant increase in [Vdot]O2 max (ml/kg · min−1) of 7.6% and a significant decrease in post step-test heart rate (13.4%) but showed no changes in body weight, height, or percent body fat. At Week 3, the comparison group showed an increase (0.9%) in body weight, but no changes were observed in the other anthropometric variables or post step-test heart rate. During the competitive season, the runners had significant changes in all blood variables excep...