Women's Reproductive Health Research Articles

Serum and urine profiles of TGF-β superfamily members in reproductive aged women

BackgroundTGF-β superfamily members are important biomarkers of reproductive health in women desiring fertility and during pregnancy. TGF-β proteins derived from the ovary and/or placenta have been detected in serum in women, but there have been very few attempts to measure them non-invasively, such as in urinary samples, and to compare them to serum concentrations. MethodsWe measured inhibin A, inhibin B, total inhibin, AMH, activin A, activin B, activin AB, follistatin, the GDF-9/BMP-15 complex, and GDF-15 in paired serum and urine samples from healthy reproductive aged women and in pregnant (second trimester) women. ResultsWe detected all hormones in serum in both pregnant and non-pregnant women. Inhibin A, total inhibin, activin A, activin AB, follistatin, and GDF-15 were significantly higher in pregnant than in non-pregnant women. GDF-15 was the only hormone consistently detected in urine. We also measured, for the first time, the GDF-9/BMP-15 functional heterodimer and the GDF-15 protein harboring the H202D polymorphism. ConclusionsWe report the successful measurement of the GDF-9/BMP-15 heterodimer (its native form) in serum and the ability to measure GDF-15 non-invasively, in urinary samples. This novel GDF-15 assay also captures the antigen in the presence of a common genetic variant.

Inositol and folates in the restoration of reproductive function in women and prevention of congenital malformations

In recent years, Ukraine has seen a significant deterioration in the reproductive health of women in the face of declining birth rates. One of the main causes of comorbidity of infertility and background pathologies is the insufficient supply of a woman's body in the pre-pregnancy period with micronutrients – folate, vitamins, myo-inositol and others. This increases the risk of complications during pregnancy and childbirth and congenital malformations.Literature analysis showed that myo-inositol in combination with folate are an extremely important way to prevent fertility disorders, complications of pregnancy and childbirth, congenital malformations and support the reproductive health of the next generation. Myo-inositol in combination with folic acid promotes the effects of luteinizing and follicle-stimulating hormones, normalization of ovarian function, oocyte quality, trophoblast invasion during blastocyst attachment, prevention of congenital malformations by neutralizing the action of homocysteine with metafolin in the pregravid period and during pregnancy and assisted reproductive technologies, reducing the incidence of miscarriage, preeclampsia and other complications. The neuroprotective effect of myo-inositol indicates the importance of its use for fetal neuroprotection in late gestation, especially in hypoxia.Fertifolin, which contains an improved combination of natural nutrients as myo-inositol 1000 mg and folic acid 100 µg in the form of metafolin (calcium L-methylfolate), successfully copes with this goal. Metafolin has greater bioavailability and more actively helps to increase the level of folate in blood plasma, in contrast to folic acid. Metafolin is characterized by fewer drug interactions and less often masks the symptoms of B12-deficient anemia, reduces the risk of anemia, placental dysfunction, malformations of the neural tube. Fertifolin is also effectively used as an adjunct in polycystic ovary syndrome and in assisted reproductive technology protocols.

CONTRACEPTIVE INCREASING CONTRACEPTIVE USE DURING THE COVID-19 at HARAPAN BUNDA CLINIC MEDAN POLONIA

The Covid-19 pandemic, besides having an impact on the economy, education and society, also impacts on health, one of which is impact on women's reproductive health services, reproductive health services for women are a form of necessity or cannot be postponed. Many women face several changes as a result of social and physical distancing, including for their reproductive health checks. One of these services is the use of contraceptives. Contraceptive use during The covid-19 pandemic is one of the efforts that must be done in couples of childbearing age (PUS) which are expected to postpone pregnancy before the covid-19 pandemic. health workers continue to monitor the use of contraception for women's reproductive health.

Education on the importance of health awareness

Efforts to reduce the number of Covid-19 cases on a daily basis can begin with simple things like developing the habit of properly hand washing. In addition, education about women's reproductive health is provided. This service is carried out at the Robbani Foundation which has 13 foster children. This service promotes a better understanding of proper hand washing techniques. This activity is expected to help reduce the spread of Covid-19 by cultivating clean living education and sharing with orphans and poor.

GAMBARAN TINGKAT PENGETAHUAN REMAJA PUTRI TENTANG KEPUTIHAN DI SEKOLAH TINGGI ILMU KESEHATAN YOGYAKARTA

ABSTRACT
 
 Background: Based on data from the World Health Organization (WHO), poor women's reproductive health problems have reached 33% of the total burden of disease suffered by women in the world, one of which is vaginal discharge (Oriza, 2018). According to (WHO), women rarely pay attention to the cleanliness of their external genitalia. Vaginal infections every year affect women worldwide 10-15% of 100 million women, for example, adolescents who are infected with candida bacteria around 15% and experience vaginal discharge
 Research methods: This research method is descriptive. This research was conducted in July 2021. The sample in this study were students of STIkes Yogyakarta, totaling 32 respondents and using purposive sampling. The instrument in this study was a knowledge questionnaire
 Results and discussion: The level of knowledge of young women about vaginal discharge in the sufficient category 15 respondents (46.9%), the level of knowledge about the meaning of vaginal discharge in the good category 15 respondents (46.9%), the level of knowledge of young women about the type of vaginal discharge in the sufficient category 17 respondents (53 ,1%), the level of knowledge of young women about the causes of vaginal discharge in the sufficient category 13 respondents 40.6%), the level of knowledge of young women about the signs and symptoms of vaginal discharge in the category of 16 respondents (50.0%), the level of knowledge of young women about prevention of vaginal discharge in the category enough 14 respondents (43.8), the level of knowledge of young women about the treatment of vaginal discharge in the sufficient category 15 people (46.9%) and the level of knowledge of young women about the treatment of vaginal discharge in the category less 25 respondents (78.1%).

Intimate Partner and Sexual Violence, Reproductive Coercion, and Reproductive Health Among American Indian and Alaska Native Women: A Narrative Interview Study.

Background: The disproportionately high prevalence of poor reproductive and sexual health outcomes among American Indian and Alaska Native (AI/AN) women is related to histories of colonization, oppression, and structural racism. Intimate partner violence (IPV) and sexual violence (SV) contribute to these health outcomes. Materials and Methods: Narrative interviews were conducted with AI/AN women from four tribal reservation communities. Interviews explored connections among sexual and reproductive health, IPV, SV, reproductive coercion (RC), and pregnancy experiences as well as women's experiences of healing and recovery. Results: Among the 56 women interviewed (aged 17-55 years, 77% were aged 40 years and younger), all described multiple exposures to violence and highlighted lack of disclosure related to sexuality, childhood abuse, SV, and historical trauma. Access to confidential reproductive health services and contraceptive education was limited. Almost half (45%) reported experiencing RC in their lifetime. Use of substances occurred in both the context of SV and for surviving after exposure to violence. Women underscored the extent to which IPV, SV, and RC are embedded in histories of colonization, racism, and ongoing oppression. Interventions that incorporate AI/AN traditions, access to culturally responsive reproductive health and advocacy services, organizations, and services that have AI/AN personnel supporting survivors, public discussion about racism, abuse, sexuality, and more accountable community responses to violence (including law enforcement) are promising pathways to healing and recovery. Conclusions: Findings may advance understanding of AI/AN women's reproductive health in the context of historical trauma and oppression. Intervention strategies that enhance resiliency of AI/AN women may promote reproductive health.

COVID-19 and gender differences in mental health in low- and middle-income countries: Young working women are more vulnerable

This study examines gender differences in the relationship between COVID-19-triggered economic hardship and mental health complaints, defined by self-reported anxiety/depression, of young people (17–29) in four low- and middle-income countries (LMICs). To do this, we use two waves of the Young Lives (YL) phone survey. Logistic regression results show that young women, on average, were more likely to report anxiety than men in Peru and Vietnam in the first survey wave (June–July 2020). However, this disparity continued to persist in all four countries in the second wave (August–October 2020) as the pandemic prolonged. Notably, we find that young women that faced economic hardship by losing job or income were more likely to report anxiety than their male counterparts. As COVID-19 cases remain consistently high in many LMICs, which limit economic activities, the vulnerability of young women may likely increase. This issue requires urgent policy attention by awareness-raising campaigns, more hotline services for emergency help, social security programs for women, and available women's sexual and reproductive health services at a specific section in hospitals.

Spousal violence against women and its consequences on pregnancy outcomes and reproductive health of women in India

BackgroundGlobally, one in three women experienced domestic violence. Alike the scenario observed in India, and a very few studies talk about violence and its consequences on women's health. Hence, the purpose of this study is to access the level of various types of spousal violence in India and to understand the association between physical, sexual and emotional violence against ever-married women by their husbands. The study further examines the consequences of spousal violence on women's health in terms of adverse pregnancy outcomes and reproductive health in India.MethodsThe study uses secondary data from National Family Health Survey-4 (NFHS-4, 2015–16). The analysis was based on a sample of ever-married women aged 15–49 years. Bivariate descriptive analysis and multiple regression analyses have been carried out to understand the association between spousal violence and its consequences on women's health.ResultsThe study finds that the physical, sexual and emotional violence experienced by ever-married women in India are 29.8%, 13.8% and 7.0%, respectively. Further, the physical and sexual violence experienced by women have a significant association with an unwanted pregnancy, abortion, miscarriages and ever had termination of pregnancies. The regression analysis shows that violence by sexual partners among battered women increased the likelihood of unwanted pregnancy. Similarly, abortion and ever had a termination of pregnancies are also adversely affected by partner violence. Further, the risk of sexually transmitted infection increases 77% by sexual violence and 44% by emotional violence among battered women. Also, Sexual violence substantially increases the risk of prolonged labour during pregnancy.ConclusionThis study revealed that one in three women experiencing violence by their husband and also it is evident that various forms of spousal violence adversely affect pregnancies outcomes and reproductive health among battered women compared to not battered.

The study of sex steroid hormone compound in green algae (Chlorophyta) for female fertility: A literature review

Reproductive organ cell damage due to oxidants can cause problems in female fertility, this situation can be prevented and overcome by consuming antioxidants such as algae. Green algae Chlorophyta also contains a steroid that is thought to be useful for normal reproductive health in women. The purpose of this study was to determine the compounds of sex steroid hormones in green algae which are important for female fertility. The systematic review method was used in this study. Based on the results of studies, it shows that green algae contain sterols which through biochemical mechanisms will form sex steroid hormones in the target organ. These hormones play an important role in the regulation of the female reproductive system and the balance of these hormones is crucial for normal fertility in women. Based on this, women should be able to maintain their reproductive health well by consuming foods that contain lots of vitamins and natural fibers that are good for the body such as green algae. Women must also be able to maintain a healthy lifestyle, change bad lifestyles, and avoid environmental risk factors that can cause infertility.

Dietary Modification for Reproductive Health in Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

ObjectiveDiet has been reported as the first-line management of polycystic ovary syndrome (PCOS). However, the relationship between diet and fertility in PCOS is still controversial. This meta-analysis aimed to evaluate whether diet could promote reproductive health in women with PCOS while providing evidence-based nutrition advice for clinical practice.MethodsSeven databases, including Cochrane Central Register of Controlled Trials, PubMed, Embase, Web of Science, and some Chinese database, were searched up to January 31, 2021. Randomized controlled trials evaluating the effects of diet in women with PCOS were included. Based on a preregistered protocol (PROSPERO CRD42019140454), the systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Two reviewers made study selection, data extraction and bias assessment independently. Risk ratios and mean difference with 95% confidence intervals were assessed by a random-effects model. Statistical heterogeneity within comparisons was evaluated by Cochran’s Q test and quantified by the I-squared (I2 ) statistic.ResultsTwenty RCTs with 1113 participants were included. Results showed diet significantly related to improved fertility outcomes (increasing clinical pregnancy, ovulation and menstrual regularity rate; reducing miscarriage rate), reproductive endocrine [increasing sex hormone-binding globulin (SHBG); decreasing Anti-Müllerian Hormone (AMH), free androgen index (FAI), total testosterone (T)] and clinical hyperandrogenism (hirsutism assessed by Ferriman-Gallwey score) in PCOS. Specifically, subgroup analyses indicated low-carbohydrate diets were superior in optimizing reproductive outcomes and calorie restriction was critical in ameliorating hyperandrogenism. Additionally, the positive effects were associated with the treatment duration. The longer the duration, the greater the improvement was.ConclusionOverall, diet is an effective intervention for improving fertility health, thus professional and dynamic dietary advice should be offered to all PCOS patients, based on the changeable circumstances, personal needs and expectations of the individuals.

Phenotypic and Clinical Traits That Correlate with Cognitive Impairment in Caucasian Females.

Background: Dementia affects more women than men. This suggests sex steroid-dependent structural and functional differences between male and female brains. Natural and iatrogenic changes to women's reproductive health may correlate with risk for dementia.Objective: To identify surrogate markers of key transitions within the reproductive axis that could correlate with dementia pathology in women.Specific Research Question: Could examination of the reproductive axis from birth to senescence expand our understanding of the gender predominance of dementia in women? Proxy measurements for fetal origins, reproduction, and age-related effects on estrogen-dependent tissues were collected to study dementia risk in women.Methods: Deidentified data were collected from 289 older Caucasian female patients from an out-patient clinic in Kansas City, Missouri. Women patients 65 years and older were offered the opportunity to join the study and written consent was obtained from all participants. Data were collected from 2017 to 2019.Results: Our subjects ranged in age from 65 to 98 years old, with a mean of 76 years old. Spearman correlation analysis showed significant correlation between dementia status and age (r = 0.219, p = 0.000), Fitzpatrick skin phototype (r = −0.141, p = 0.019), birth order (r = 0.151, p = 0.028), current height as measured in the office (r = −0.215, p = 0.001), and maximum height per patient recall (r = −0.173, p = 0.005). Results from the logistic regression model show that specific predictors of risk for dementia were age (odds ratio [OR] = 1.082 [1.034–1.132]; p = 0.0007), Fitzpatrick skin phototype 1 versus 3 (OR = 8.508 [1.075–67.313]; p = 0.0227), and current height (OR = 0.766 [0.642–0.915]; p = 0.0032). Of the four variables related to fetal origins: maternal age, number of siblings, birth order, and age difference between the subject and the next older sibling, none were found to be statistically significant. Since age is a significant predictor of risk for dementia, it was included as a covariate in the aforementioned logistic regression models.Conclusions: Our results showed that dementia in Caucasian women was associated with age, lower Fitzpatrick phototype, and current height. Dementia-related pathological processes in the brain may accrue over a woman's lifetime.

Women of Color’s Reproductive Perils Reproduced

Last year, women detained at a Georgia ICE detention center accused a doctor of conducting various hysterectomies that were unwanted or without consent. These allegations echo past sterilization abuses on women of color and challenge us to recall some historical accounts of women's sterilization in Black and Brown communities in America, including eugenics programs targeting poor women of color. When particularly examining the women's reproductive health in the carceral system, there are direct conflicts between providing proper healthcare and human rights protections and the economic interests of privately operated detention centers. This essay reviews these concerns and recommends changes from government and carceral facilities.

Потенційний вплив мелатоніну на розвиток міоми матки у жінок репродуктивного віку (огляд літератури)

For a long time, Ukraine has been showing negative dynamics between birth and death rates. The demographic situation in any country is an important indicator. Therefore, the issue of women's health and ability to reproduce is significant and urgent. The purpose of the study was to analyze current data from domestic and foreign literature on provoking factors, etiology and pathogenesis of uterine fibroids, new approaches to treatment and the impact of this pathology on a woman's reproductive potential. Hyperplastic processes of the uterus in women of reproductive age are among the most common gynecological diseases. Uterine leiomyoma is the most common benign proliferative pathology. The presence of uterine leiomyoma leads to disorders of women's reproductive health, is one of the causes of infertility, in addition, significantly affects the quality of life of the patient due to constant pain, excessive uterine bleeding, dysfunction of adjacent organs. Many studies confirm the unfavorable course of pregnancy and the postpartum period in women with fibroids, namely: complicated pregnancy, reproductive losses, birth defects and postpartum complications. Despite the intensive work of scientists, the implementation of a large number of studies, the pathogenesis to this day remains multifaceted and poorly understood. Results and discussion. After analyzing current data from domestic and foreign literature on provoking factors, etiology and pathogenesis of uterine fibroids, the review article presents data on current opportunities, new approaches to treatment and the impact of this pathology on a woman's reproductive potential. For a long time, the pineal gland with the hormone melatonin has not been studied. During the scientific research, the review of the current domestic and foreign literature on the potential inhibitory effect of melatonin on uterine fibroid cells, and the direct and indirect effect on fertility was reviewed and analyzed. As a result of analysis of experimental and clinical data presented in the literature, it can be argued that melatonin has the ability not only to regulate biological rhythms, but also that it is promising to study metabolic and immunomodulatory effects, as well as antitumor effects, which gives us a chance to reduce surgery of this group of patients. Conclusion. The information presented in the review suggests that melatonin has the potential as a therapeutic agent for clinical trials against uterine leiomyoma in women of reproductive age. Therefore, there is a need to study deeply the etiopathogenesis of uterine leiomyoma and in particular the effect of melatonin on growth, reduction of surgical interventions, the impact on the pre- and postoperative period, and to determine melatonin as a therapeutic drug

Climate change, women's health, and the role of obstetricians and gynecologists in leadership.

Climate change is one of the major global health threats to the world's population. It is brought on by global warming due in large part to increasing levels of greenhouse gases resulting from human activity, including burning fossil fuels (carbon dioxide), animal husbandry (methane from manure), industry emissions (ozone, nitrogen oxides, sulfur dioxide), vehicle/factory exhaust, and chlorofluorocarbon aerosols that trap extra heat in the earth's atmosphere. Resulting extremes of weather give rise to wildfires, air pollution, changes in ecology, and floods. These in turn result in displacement of populations, family disruption, violence, and major impacts on water quality and availability, food security, public health and economic infrastructures, and limited abilities for civil society to maintain citizen safety. Climate change also has direct impacts on human health and well‐being. Particularly vulnerable populations are affected, including women, pregnant women, children, the disabled, and the elderly, who comprise the majority of the poor globally. Additionally, the effects of climate change disproportionally affect disadvantaged communities, including low income and communities of color, and lower‐income countries that are at highest risk of adverse impacts when disasters occur due to inequitable distribution of resources and their socioeconomic status. The climate crisis is tilting the risk balance unfavorably for women's sexual and reproductive health and rights as well as newborn and child health. Obstetrician/gynecologists have the unique opportunity to raise awareness, educate, and advocate for mitigation strategies to reverse climate change affecting our patients and their families. This article puts climate change in the context of women's reproductive health as a public health issue, a social justice issue, a human rights issue, an economic issue, a political issue, and a gender issue that needs our attention now for the health and well‐being of this and future generations. FIGO joins a broad coalition of international researchers and the medical community in stating that the current climate crisis presents an imminent health risk to pregnant people, developing fetuses, and reproductive health, and recognizing that we need society‐wide solutions, government policies, and global cooperation to address and reduce contributors, including fossil fuel production, to climate change.

Fertility Booster: Butter Fruit

Infertility is considered to be a global concern that affects many aspects of life for both sexes. The infertility epidemic is fast approaching and its numbers have reached 186 million people worldwide. The negative aspects of an unhealthy diet can be linked to reproductive health in women and adequate nutritional support can improve fertility. Most health expert recommendations and dietary guidelines acknowledge that certain foods or diet plans can actually improve fertility specifically, diet plans involving accumulated fruit and vegetable intake. However, the amount of nutrients varies significantly among fruits and vegetables, and not all fruit and vegetable choices are thought of “nutrient-rich”.Butter Fruit are distinctive, they contain abundant higher amounts of the key nutrients like folate and potassium, that are usually under-consumed in maternal diets and are coupled to spice up fertility and as well as cut back various sorts of diseases and deficiency as they contain essential nutrients and bioactive compounds.The present review article aims at addressing the proof that Butter Fruit could also be a singular nutrition for reinforcing fertility during pre-conception period.

Menopause workplace policy: The way forward or backward?

Workplace policies regarding women's reproductive and menopausal health are garnering global attention. The peri- and post-menopause stages may be turbulent times for many women, with some experiencing debilitating symptoms and some none at all. While the symptoms of menopause should be recognised by employers due to their various impacts, the implementation of policies that pertain to all women can alienate older female workers by creating prejudice surrounding work capability. This piece identifies other avenues for the inclusion of menopausal symptoms through pre-existing policy and highlights the issues facing menopausal women in this current age.

Access to the Emergency Contraceptive Pill and Women's Reproductive Health: Evidence From Public Reform in Chile.

We examine the sharp expansion in availability of the emergency contraceptive pill in Chile following legalized access through municipal public health care centers. We study the period 2002-2016 and a broad rollout of the emergency contraceptive pill occurring between 2008 and 2011. By combining a number of administrative data sets on health outcomes and pharmaceutical use, and using event-study and difference-in-differences methods, we document that this expansion improved certain classes of women's reproductive health outcomes, notably reducing rates of abortion-related morbidity. These improvements were greater in areas of the country where the rollout of the emergency contraceptive pill was more extensive. We also document some evidence that refusal to provide the emergency contraceptive pill upon a women's request was linked with a worsening in reproductive health outcomes. These results point to the importance of contraceptive access as a determinant of women's reproductive health and well-being and relates to a growing body of work documenting the importance of women's autonomy as a determinant of health.

Examining women's health through a psychosocial lens.

During the COPASAH Global Symposium 2019, a group of therapists and mental health practitioners tried to highlight the issue of women's mental health with two specific focuses, one being the lived experiences of persons living with mental illness and the secondary burn-out and shame faced by their caretakers. The second session explored the contours of somatisation that is often seen in the human body as a result of the impact of trauma. The participants reflected on the value of lived experiences and also discussed the challenges faced in getting representation for people living with mental illness. The challenges listed by participants were concentrated around the participation and representation of persons living with intellectual disability and psychosocial disability. Somatisation of traumatic experiences needs recognition in a country like India where women's life-stressors exist right from childhood that keeps them on the threshold of mental illness and/or psychosomatic illnesses. Psychosocial health issues are relegated to a subordinate category of discussion while public health, reproductive health, and health rights feature in mainstream discussions in various seminars, researches and conferences in India. This paper is based on two sessions of the COPASAH Global Symposium 2019 and focuses on the gender and psychosocial dimensions of health from the framework of women being subjected to unpaid care work, through social and reproductive labour and stressors resulting in psycho-social distress. To this end, it is important to build a community of practitioners that looks beyond the reproductive health of women.

How Information Helps on Increasing Students' Understanding of Adolescent Reproductive Health At School

This study aims to describe the level of students' understanding of adolescent reproductive health and to examine how the influence of information on their level of understanding. The research used was <em>pre-experimental designs </em>with a <em>one-group pretest-posttest design w</em>ith a total sample of 41 people. The instruments used in this study were the Students' Reproductive Health Understanding Level Scale (α=0.328) and interviews. Data were analyzed using <em>descriptive percentage </em>formula and <em>Wilcoxon signed rank test. </em>The results showed that the level of understanding of students about adolescent reproductive health is in the low criteria with an average value of 55.75%. Based on the results of the <em>Wilcoxon signed rank test</em>, it shows that there is an effect of providing information helps on the level of understanding of adolescent reproductive health. With the provision of information helps, students can gain an understanding of the material presented, namely the understanding of women's reproductive health. In addition, there is a prevention function so that students are able to avoid irresponsible behavior towards their own reproductive health.

Бактеріальний вагіноз та вульвовагінальний кандидоз у жінок репродуктивного віку з надлишковою масою тіла та ожирінням (огляд літератури)

In a review article of literary sources, domestic, foreign authors and their own research, modern views are highlighted, often problems and debatable, the prevalence of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) among women with overweight and obesity, women of reproductive age. Vulvovaginal candidiasis (VVC) It ranks second among all vaginal infections and is one of the most common mental reasons for women to visit a gynecologist. Obesity and overweight play an important negative role in gynecological and obstetric practice. There has been a significant increase in C. albicans non-albicans in overweight women of reproductive age, and has a negative effect on the reproductive health of women. The article presents the results of a comparative study on the clinical and laboratory effectiveness of local therapy for bacterial vaginosis and IHC in overweight women. Against the background of metabolic disorders, there is an increase in the frequency of infectious pathology of the urogenital tract. Numerous literature data indicate that fungi of the city of Candida are part of various microbial associations and an important factor in their active growth is the deficiency of lactobacilli that produce H2O2. Data on bacterial vaginosis and vulvovaginal candidiasis, development and role of metabolic disorders in the pathogenesis of BV and VVC are presented. Increasing the effectiveness of local treatment of disorders of the vaginal biocenosis in women with overweight and obesity by using individualized dietary nutrition, means of correcting the intestinal biocenosis and metabolic therapy, an integrated approach to the therapy of women of reproductive age showed more effective results. It has been found that overweight and obesity negatively affect the reproductive system of women. Irregular menstrual cycles, secondary amenorrhea, infertility, endometrial hyperplastic processes are often associated with overweight and obesity. In many cases, BV is combined with intestinal dysbiosis. In this case, vaginosis can be considered as a manifestation of a systemic dysbiotic process, affects not only the microbiota of the genitourinary system, but also the endogenous microflora in various cavities of the macroorganism, provided that it is influenced by any exogenous and endogenous factors. No conflict of interest was declared by the author. Key words: bacterial vaginosis, vulvovaginal candidiasis, overweight, obesity.