In this paper, we investigate the inter-tier interference coordination for a heterogeneous network (HetNet), where both macro and small cells work in the frequency-division duplexing mode and share the same spectrum. A 2-D large-scale antenna array is deployed at a macro-base station (BS), while conventional multiple antenna array is deployed at each small cell. First, we derive an approximation of macro-users’ signal-to-interference-plus-noise ratio (SINR), under the assumption of only statistical channel-state information (CSI) at macro-BS, and a 3-D beamforming transmission scheme is applied for macro-users. A lower-bound of small-cell users’ expected SINR is also derived using the property of complex Wishart matrix. Based on these, simple metrics are derived to measure the inter-tier interference. Then, new interference coordination algorithms are proposed to achieve a good tradeoff for the performance and traffic between macro-cells and small cells. The proposed algorithms require only a few additional statistical CSI. Moreover, we derive tractable ergodic rate approximation of both the macro-cell and small-cell users which are shown to match well with the Monte Carlo results.