In order to study the performance change and interactions between the main structure and glass curtain wall under the individual and coupled actions of wind and earthquake loadings, on the basis of a 98 m high frame-core wall structure in highly seismic region, a finite element analysis model was built by adding the glass curtain wall according to the specifications. Three groups of three-dimensional seismic records are selected according to the site conditions, and the wind pressure time-history of different return periods was obtained through a 1∶440 scale wind tunnel model test. Then the effects of individual and coupled actions of wind and earthquake on the behavior of the main structure and glass curtain wall was studied by the nonlinear dynamic analysis. The results show that the influence of the main structure on the glass curtain wall was greater than that of the glass curtain wall on the main structure. Whether under the individual or coupled actions of wind and earthquake, the inter-story deformation of the main structure was larger than the deformation of the glass curtain wall itself. Under the design and super-intensity earthquake loadings, the nonlinear response of the main structure and the failure range of the glass curtain wall increased with the load increase, and the growth of structural deformation was greater than the base shear's growth. Under the action of wind, the glass curtain wall was not damaged, the main structure was in an elastic stage, and the base shear, top displacement and the maximum story drift ratio increased linearly. Compared with the effect of rare earthquake alone, when the rare earthquake was coupled with 1.1 times wind pressure of a 100-year return period, the torsional effect appears in the structure, and the story drift ratio increased from 1.0 to 1.3. The nonlinear response of the main structure and the glass curtain wall is greater than the simple superposition of wind and earthquake alone. The top displacement and the maximum story drift were 121% and 106% of the sum of wind and earthquake alone. Under the rare earthquake, the coupling action of the rare earthquake and wind earthquake, the failure of glass curtain wall is more likely to happen on the side parallel to the main direction of earthquake.