Purpose This study aims to analyze the multi-slip effects of entropy generation in steady non-linear magnetohydrodynamics thermal radiation with Williamson nanofluid flow across a porous stretched sheet near a stagnation point. Also, the qualities of viscous dissipation, Cattaneo–Christove heat flux and Arrhenius activation energy are taken into account. Thermophoresis, Brownian motion and Joule heating are also considered. Design/methodology/approach The Navier–Stokes equation, the thermal energy equation and the Solutal concentration equations are the governing mathematical equations that describe the flow and heat and mass transfer phenomena for fluid domains. By using the proper similarity transformations, a set of ordinary differential equationss are retrieved from boundary flow equations. The classical Runge–Kutta fifth-order algorithm along with the shooting technique is implemented to solve the obtained first order differential equations. Findings The study concludes that the temperature distribution boosting for thermal radiation, magnetic field and Eckert number where as the velocity and entropy generation escalate for the Williamson parameter, diffusion parameter and Brinkman number. The skin-friction and heat and mass transfer rate increases with the fluid injection. In addition, tabulated values of friction drag and rate of heat and mass transfer for various values of constraints are provided. Originality/value The comparison of the present results is carried out with the published results and noted a good agreement.