Wide Weight Range Research Articles

Evaluation of a Camera-Based Monitoring Solution Against Regulated Medical Devices to Measure Heart Rate, Respiratory Rate, Oxygen Saturation, and Blood Pressure.

Background Regularly monitoring common physiological signs, including heart rate, blood pressure, and oxygen saturation, can effectively prevent or detect several potential conditions. In particular, cardiovascular diseases (CVDs) are a worldwide concern. According to the World Health Organization, 31% of all deaths worldwide are from CVDs. Recently, the coronavirus disease 2019 pandemic has increased the interest in remote monitoring. At present, contact devices are required to extract most of an individual's physiological information, which can be inconvenient for users and may cause discomfort. Methodology However, remote photoplethysmography (rPPG) technology offers a solution for this issue, enabling contactless monitoring of the blood volume pulse signal using a regular camera. Ultimately, it can provide the same physiological information as a contact device.In this paper, we propose an evaluation of Vastmindz's rPPG technology against medical devices in a clinical environment with a variety of subjects in a wide range of age, height, weight, and baseline vital signs. Results This study confirmed the findings that the contactless technology for the estimation of vitals proposed by Vastmindz was able to estimate heart rate, respiratory rate, and oxygen saturation with a mean error of ±3 units as well as ±10 mmHg for systolic and diastolic blood pressure. Conclusions Reported results have shown that Vastmindz's rPPG technology was able to meet the initial hypothesis and is acceptable for users who want to understand their general health and wellness.

Subject-wise model generalization through pooling and patching for regression: Application on non-invasive systolic blood pressure estimation

Background:Subject-wise modeling using machine learning is useful in many applications requiring low error and complexity, such as wearable medical devices. However, regression accuracy depends highly on the data available to train the model and the model’s generalization ability. Adversely, the prediction error may increase severely if unknown data patterns test the model; such a model is known to be overfitted. In medicine-related applications, such as Non-Invasive Blood Pressure (NIBP) estimation, the high error renders the estimation model useless and dangerous. Methods:This paper presents a novel algorithm to handle overfitting by editing the training data to achieve generalization for subject-wise models. The pooling and patching (PaP) algorithms use a relatively short record segment of a subject as a Key-Segment (KS) to search through a larger dataset for similar subjects. Then samples taken from the matched subjects’ pool records are used to patch the original subject’s KS. Due to the significance of systolic blood pressure (SBP) and the complexity of its variability, non-invasive estimation of SBP from electrocardiography (ECG) and photoplethysmography (PPG) is introduced as an application to assess the algorithm. The study was performed on 2051 subjects with a wide range of age, height, weight, length, and health status. The subjects’ records were taken from a large public dataset, VitalDB, which is acquired from subjects undergoing different surgeries. Finally, all the results are obtained without using other model generalization techniques. Results:The generalization effect of the proposed algorithm, PaP, significantly outperformed cross-validation, which is widely used in regression model generalization. Moreover, the testing results show that a KS of 200 to 2000 samples is sufficient for providing high accuracy for much longer testing data of about 12000 to 24000 samples long, which is less than %10 of the record length on average. Furthermore, compared to other works based on the same dataset, PaP provides a significantly lower mean error of -0.75 ± 5.51 mmHg, with a small training data portion of 15% over 2051 subjects.

A Biomimetic Soft‐Rigid Hybrid Finger with Autonomous Lateral Stiffness Enhancement

The application of soft robotics improves the compliance of robotic fingers, which, however, usually loses sufficient stiffness. Here, a biomimetic soft‐rigid hybrid (BSH) finger that can achieve both inherent compliance and autonomous lateral stiffness enhancement is proposed. Driven by pneumatic artificial muscles, the proposed two‐joined BSH finger can produce two flexion degrees of freedom (DOFs) and one lateral DOF motion. Imitating the human finger anatomy, the BSH finger is designed with elliptical bony ridges and eccentrically arranged ligaments. By leveraging the contact interference of the ridges and tensioning of the ligaments, the lateral stiffness of the BSH finger can be autonomously enhanced through finger flexion. During its natural stage, the lateral stiffness is relatively low to ensure mobility and compliance, while in its flexion stage, its lateral stiffness can increase to resist lateral deflection and high payload. To further investigate the advantages of the design, four BSH fingers are assembled into a robotic hand prototype with three grasping types including enveloping grasp, precise pinch, and power grasp. Experimental results demonstrate that the robotic hand prototype is capable of grasping various objects with a wide range of diameters, lengths, thicknesses, and weights, which will verify the effectiveness of the design methodology.

Content and gain of macro minerals in the empty body and body tissues of growing bulls

This research aimed to generate basic data for specifying the macro mineral requirements of beef bulls. Hence, the contents of the macro minerals calcium, phosphorus, sodium, potassium, sulfur, and magnesium in the empty body and body tissue fractions of growing Fleckvieh (German Simmental) bulls with 120–780 kg live weight were determined. Results were used to calculate mineral gain rates in bulls within a wide weight range from 100 to 800 kg live weight. Calcium and phosphorus represented the largest shares in the animals' bodies. Body mineral content changed during animal growth due to progressing bone mineralization and increasing amounts of fat in all body tissues. Peak mineral gain rates were observed for calcium, phosphorus, and magnesium during the 200–400 kg live weight range. The gain rates of sodium, potassium, and sulfur declined steadily during cattle growth. The provided data allow to adjust the existing values of net mineral requirements of growing Fleckvieh bulls within the factorial requirement calculation method.

Is lightweighting glass bottles for wine an option? Linking technical requirements and consumer attitude

AbstractWhen discussing glass bottles within the context of circular economy, reusability and recyclability are highlighted. However, it is recognised the relevant environmental footprint of glass production due to energy consumption and the impact of transportation of the empty bottles from the production site to the filling plants. Reducing the weight of the bottles has become possible through design and production technologies advances. However, consumer perceptions and technical requirements must be integrated and may conflict. This work aims at contributing to better understanding the relationship between the wine glass bottle weight, consumer perception of wine quality and acceptance of lighter bottles and recognition of sustainability factors related to packaging. Bordeaux shaped bottles are the lightest in the wine market, when compared to Burgundy or Conical, but also the ones with a wider weight range. Bordeaux bottles with 100 g of weight difference could be found for 750‐cL capacity. Design features, punt and finish/neck dimensions were found to limit the reduction in bottle weight. Consumer survey results indicate a correlation between the bottle weight and the wine price. Portuguese consumers tend to associate a heavier bottle with better quality and higher price, particularly those consumers with higher wine expertise. The three top concerns regarding packaging are, by order, being plastic‐free, recyclable and reusable. There is very low awareness on the importance of lightweighting glass bottles as a measure to improve sustainability. More than 80% of the respondents indicated the increase of recycled content as the measure contributing the most to sustainability.

A Dimensionality Reduction Approach in Helicopter Hover Performance Flight Testing

The power required to hover a helicopter is fundamental to any new or modified performance flight-testing effort. The conventional method of relating two nondimensional variables (coefficients of power and weight) is overly simplified and neglects compressibility effects in the power required to hover under a wide range of gross weights and atmospheric conditions. An alternative flight-test method for assessing hover performance while addressing this deficiency of the conventional method is proposed. The method uses an original list of 15 corrected variables derived from fundamental dimensional analysis, which is further reduced by means of dimensionality reduction to include only the most essential and effective predictors. The method is demonstrated using data of a Bell Jet-Ranger and shows that at the 95% confidence level; the averaged prediction error is only 0.9 hp (0.3% of the maximum continuous power). Using the same data, the conventional method yields a much larger averaged prediction error of 1.7 hp.

NUCB2/nesfatin-1 is associated with severity of eating disorder symptoms in female patients with obesity

BackgroundNesfatin-1 has been described as an anorexigenic peptide. Comprehensive evidence also points towards an involvement of nesfatin-1 in the modulation of emotional pathways with a sex-specific regulation of nesfatin-1 in association with anxiety. Although the implication of nesfatin-1 in the regulation of food intake is well-established in animals, data in humans are lacking. Therefore, we investigated a possible association of circulating NUCB2/nesfatin-1 with eating disorder symptoms in female and male patients displaying a wide range of body weight. MethodsWe enrolled 243 inpatients (177 female, 66 male) hospitalized due to anorexia nervosa (n = 66) or obesity (n = 144) or with normal weight and suffering from somatoform, adjustment, depressive or anxiety disorders (n = 33). Plasma samples (NUCB2/nesfatin-1 levels measured by ELISA) and measures of eating disorder symptoms (by EDI-2, range 0–100) were obtained within three days after admission. ResultsThe study population displayed a distinct prevalence of eating disorder symptoms with female patients with anorexia nervosa (+ 77.0%, p < 0.001) and obesity (+ 87.9%, p < 0.001) reported significantly higher EDI-2 scores than normal weight patients of the same sex. Accordingly, males with anorexia nervosa (+ 39.7%, p < 0.05) and obesity (+ 51.7%, p < 0.001) had significantly higher EDI-2 scores than males with normal weight. Within the same BMI group, women displayed significantly higher scores than men (+ 21.4%, p < 0.05 in patients with anorexia nervosa, + 18.8%, p < 0.001 in participants with obesity). We observed a positive correlation between NUCB2/nesfatin-1 levels and EDI-2 total scores in female patients with obesity (r = 0.285, p = 0.015), whereas no associations were found in other subgroups. A positive correlation between NUCB2/nesfatin-1 levels and BMI was only observed in the male study population (r = 0.315, p = 0.018). ConclusionsNUCB2/nesfatin-1 plasma levels were positively associated with EDI-2 total scores in women with obesity, while no association was observable in men. The lacking association of NUCB2/nesfatin-1 and EDI-2 total scores in female patients with anorexia nervosa might be due to already low NUCB2/nesfatin-1 plasma levels. Whether NUCB2/nesfatin-1 is selectively involved in eating behavior in women with obesity will have to be further investigated.

Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors.

Background and ObjectiveA phase I/II trial evaluated the safety, antitumor activity, and pharmacokinetics of avelumab (anti-PD-L1 antibody) in pediatric patients with refractory/relapsed solid tumors (NCT03451825). This study aimed to inform avelumab dose selection in pediatric populations using population pharmacokinetic modeling and simulations.MethodsPatients aged < 18 years with refractory/relapsed solid tumors enrolled in phase I received avelumab 10 or 20 mg/kg intravenously every 2 weeks. A pediatric population pharmacokinetic model was developed via the frequentist prior approach.ResultsPharmacokinetic parameters from 21 patients who received avelumab 10 mg/kg (n = 6) or 20 mg/kg (n = 15) were analyzed. Patients had a wide range of weights and ages (medians, 37.3 kg and 12 years). Exposures with 10-mg/kg dosing were lower vs adult dosing, particularly in patients weighing < 40 kg, whereas 20-mg/kg dosing achieved or exceeded adult exposures, irrespective of body weight. A two-compartment linear model with time-varying clearance using body weight as a covariate, with the frequentist prior approach, best described pediatric data. In this model, optimal overlap in exposure with adult data was achieved with 800 mg every 2 weeks for patients aged ≥ 12 years and weighing ≥ 40 kg, and 15 mg/kg every 2 weeks for patients aged < 12 years or weighing < 40 kg.ConclusionsBased on exposure matching, the recommended doses for further avelumab studies, including combination studies, are 15 mg/kg every 2 weeks for pediatric patients aged < 12 years or weighing < 40 kg and the adult flat dose of 800 mg every 2 weeks for pediatric patients aged ≥ 12 years and weighing ≥ 40 kg.Clinical Trial RegistrationClinicalTrials.gov NCT03451825.Supplementary InformationThe online version contains supplementary material available at 10.1007/s40262-022-01111-8.

Allometry of Mexican hogfish (Bodianus diplotaenia) for predicting the body length of individuals from two pre‐Columbian sites in the Pearl Island archipelago (Panama)

AbstractThe Mexican hogfish (Osteichthyes: Labridae, Bodianus diplotaenia Gill, 1862) is widely distributed throughout the tropical eastern Pacific from the Gulf of California to northern Peru, including all oceanic islands. Artisanal fishers occasionally capture it today and its remains are recovered at pre‐Columbian dwelling sites along the Pacific Coast of America. This paper addresses the advantages of using allometry to estimate size ranges of Mexican hogfish in pre‐Hispanic archeological samples from two ancient settlements in the Pearl Island archipelago of Panama: (1) Playa Don Bernardo (PdB), a preceramic site (6.2–5.6 kya), and (2) Bayoneta Island (BY‐10), a ceramic site (~1 kya). For creating the allometric model, a modern collection composed of 39 individuals covering a wide range of sizes and weights was used. All individuals have complete information about their total length (TL) and standard length (SL), which were recorded in millimeters (mm), and their total fresh weight (W) in grams (g). The TL of the sample ranged between 265 and 750 mm, and the SL between 210 and 487 mm. The W ranged between 273 and 3450 g. The most frequent bones (11) and otoliths were selected and 29 measurements were taken. The total length–weight relationship was W = 2E−05 TL3.0857 with R2 = 0.984. In general, it was observed that the relationships between the TL and the bone measurements had a strong correlation (R2 &gt; 0.95). At PdB, the mean reconstructed length was 289.6 mm (TL), and at BY‐10, it was 283.6 mm (TL). The study of the archeological samples of B. diplotaenia could be used as a point of reference in modern ecological studies and fisheries management particularly in the Pearl Island archipelago.

Adipsin Serum Concentrations and Adipose Tissue Expression in People with Obesity and Type 2 Diabetes.

(1) Adipsin is an adipokine that may link increased fat mass and adipose tissue dysfunction to obesity-related cardiometabolic diseases. Here, we investigated whether adipsin serum concentrations and adipose tissue (AT) adipsin mRNA expression are related to parameters of AT function, obesity and type 2 diabetes (T2D). (2) Methods: A cohort of 637 individuals with a wide range of age and body weight (Age: 18–85 years; BMI: 19–70 kg/m2) with (n = 237) or without (n = 400) T2D was analyzed for serum adipsin concentrations by ELISA and visceral (VAT) and subcutaneous (SAT) adipsin mRNA expression by RT-PCR. (3) Results: Adipsin serum concentrations were significantly higher in patients with T2D compared to normoglycemic individuals. We found significant positive univariate relationships of adipsin serum concentrations with age (r = 0.282, p < 0.001), body weight (r = 0.264, p < 0.001), fasting plasma glucose (r = 0.136, p = 0.006) and leptin serum concentrations (r = 0.362, p < 0.001). Neither VAT nor SAT adipsin mRNA expression correlated with adipsin serum concentrations after adjusting for age, sex and BMI. Independent of T2D status, we found significantly higher adipsin expression in SAT compared to VAT (4) Conclusions: Our data suggest that adipsin serum concentrations are strongly related to obesity and age. However, neither circulating adipsin nor adipsin AT expression reflects parameters of impaired glucose or lipid metabolism in patients with obesity with or without T2D.

Novel Design of a Rotation Center Auto-Matched Ankle Rehabilitation Exoskeleton With Decoupled Control Capacity

Abstract This article presents a novel ankle rehabilitation exoskeleton for poststroke patients, the rotational center of which can automatically conform to each individual user’s ankle complex, once they wear the exoskeleton; this property always holds regardless of the point at which the exoskeleton is attached to the human shank. This exoskeleton has 2 rotation degree-of-freedoms (DOFs) and is able to provide 2 different rotation patterns via reconfiguration. In the combined-rotation pattern arrangement, the mechanism can generate all three kinds of rotations that the ankle complex is naturally capable of realizing. Among these rotational motions, the adduction/abduction rotation is a coupled motion. This rotation can be further reduced, or eliminated, by minimizing the distance between the lower connection points of the actuated links and the human ankle complex, and vice versa. For the other rotation pattern, a 90-degree arrangement of the side link offers decoupled motion control of the mechanism. Numerical studies reveal that the required rehabilitation workspace for dynamical gait exercises can be achieved with high dexterity, without generating singularities. Further investigations indicate that this mechanism has great potential for rehabilitating poststroke patients of a wide range of heights and weights.

Estimated Energy Requirements of Infants and Young Children up to 24 Months of Age.

ABSTRACTBackgroundEstablishing energy requirements in infants and young children is important in developing age-appropriate diet recommendations but most published guidelines for energy requirements have 1 or more limitations related to the data underlying the calculations.ObjectiveTo develop a comprehensive set of daily energy requirements for infants and young children aged 0–24 mo meeting the ideals of worldwide applicability to all healthy children based on the use of the doubly labeled water (DLW) technique to measure total energy expenditure (TEE), the use of recent, international growth charts, and calculation of values across a wide range of body weight.MethodsDaily estimated energy requirements (EERs) were calculated in 1-mo increments from 0 to 24 mo for boys, girls, and combined, using as inputs the following: 1) TEE measured using the DLW technique, 2) energy deposition estimates from the Institute of Medicine, and 3) body weight values from the 25th to 75th percentiles from the 2006 WHO growth charts. EERs were combined for age groups 0 to <6, 6–8, 9–11, and 12–24 mo by averaging EERs from individual months. The EER calculations were supported by a systematic literature review and a meta-regression of existing studies.ResultsEnergy requirements naturally increase with age and are slightly higher in boys than in girls. The EERs derived in this study are similar to those in other recent international efforts.ConclusionsThis updated set of EERs for infants and young children expand and improve upon the methodology used to establish previous published guidelines. These estimates have multiple potential uses including planning age-appropriate menus for the complementary feeding period, the development of foods that are more precisely targeted to the needs of infants and children at particular ages, and establishing macronutrient requirements within specific age groups based on a percentage of energy, such as dietary fat.

Recent advancements of thermochemical conversion of plastic waste to biofuel-A review

Advancement and modernization have brought about a significant rise in all kind of commodities production. Plastics have been labelling as one of the materials due to its wide range of applications, light weight, versatility and low cost. Over the decades, the global plastic production has continuously increased to fulfil the global market. This phenomenon has resulted in the depletion of non-renewable fossil fuel since plastics are the petroleum-based material. Apart from that, the disposal of plastic wastes in landfills are also imposing risk on human and animal’s health as well as causing groundwater contamination. Thus, a sustainable and an effective plastic waste treatment is essential to overcome the related issue. Recycling and energy recovery methods are of the alternatives that have been discussed and practiced in many countries to reduce the plastic waste generation. Although recycling methods are highly effective, the high labor cost for the separation process and the emission of greenhouse gases during the process have reduced the process attractiveness. Due to these drawbacks, researchers have diverted their attention to the energy recovery field specifically on the thermochemical conversion method. Extensive research works have been carried out on the technology development to convert the plastic waste to bio-fuel. Although extensive research works have been carried out on the technology development to convert the plastic waste to bio-fuel, but there is still a lack of comparative discussion between the recent technologies, specifically on the economic feasibility in industrial scale. Thus, this paper aims to provide an overview on the strength and weakness of each thermochemical technologies such as a) Microwave assisted pyrolysis b) Supercritical gasification and C) Plasma gasification.

The use of Amplatzer vascular plug II in 32 consecutive dogs for transvenous occlusion of patent ductus arteriosus

ObjectivesTo describe the use of the Amplatzer vascular plug II (AVPII) for transvenous occlusion of patent ductus arteriosus in a non-selective population of dogs, with a focus on the surgical technique, short term outcome and associated complications. Animals, materials and methodsRetrospective study. Records of thirty-two consecutive dogs treated for a left-to-right shunting patent ductus arteriosus with the AVPII were reviewed. ResultsDuctal occlusion with an AVPII occlusion device was attempted in 32 dogs weighing 1.1–53.8 kg. Transvenous occlusion was successful in 30 dogs. One dog required a transarterial approach for occlusion. One dog died during catheterisation of the right heart but prior to transductal catheterisation. Mean ductal ampulla diameter was 7.9 mm (range, 4.1–15.4 mm) and median size of deployed devices was 10 mm (range 4–20 mm). Mean device to ampulla ratio was 1.34 ± 0.15. Device was positioned in situ with no residual flow on follow-up echocardiographic assessment (> one month) in all dogs where deployment was attempted. Occlusion success rate was 96.9% and mortality rate was 3.1%. Four dogs (13.3%) demonstrated minor complications, with none having long-term significance. ConclusionsThe use of AVPII device via a transvenous approach is a feasible and effective method for occlusion of a left-to-right shunting patent ductus arteriosus in dogs of a wide range of weight. The method described may complement existing catheter-based occlusion methods.

Congruences for level $1$ cusp forms of half-integral weight

Suppose that $\ell \geq 5$ is prime. For a positive integer $N$ with $4 \mid N$, previous works studied properties of half-integral weight modular forms on $\Gamma_0(N)$ which are supported on finitely many square classes modulo $\ell$, in some cases proving that these forms are congruent to the image of a single variable theta series under some number of iterations of the Ramanujan $\Theta$-operator. Here, we study the analogous problem for modular forms of half-integral weight on $\operatorname{SL}_{2}(\mathbb{Z})$. Let $\eta$ be the Dedekind eta function. For a wide range of weights, we prove that every half-integral weight modular form on $\operatorname{SL}_{2}(\mathbb{Z})$ which is supported on finitely many square classes modulo $\ell$ can be written modulo $\ell$ in terms of $\eta^{\ell}$ and an iterated derivative of $\eta$.

High-Force Fabric-Based Pneumatic Actuators With Asymmetric Chambers and Interference-Reinforced Structure for Soft Wearable Assistive Gloves

Fabric-based pneumatic actuators (FPAs) are promising in the design of soft wearable assistive gloves, owing to the lightweight and compliant advantages. However, the existing FPAs generally suffer from small output force, limiting users’ applications. This letter presents a new class of high-force FPAs (HFFPAs) that harness asymmetric chambers and interference-reinforced structure for soft wearable assistive gloves. Different from the classical FPAs with symmetric chamber (i.e., Line chamber) fabricated by two identical layers of textiles, we design FPAs with asymmetric chambers (i.e., Arch and Semicircle chambers) fabricated by two unidentical layers of textiles. To further improve the output force, we introduce interference pads on adjacent-pleat surfaces to reinforce the stiffness of the FPAs. We next characterize the joint torque and the tip blocked force of six kinds of FPAs (i.e., Line, Line-pad, Arch, Arch-pad, Semicircle, and Semicircle-pad FPAs). Experimental results demonstrate that the Semicircle-pad FPA shows the best performance, whose joint torque and tip blocked force are improved by 510% and 478% at 150 kPa than the commonly used Line FPA. We further integrate HFFPAs on soft wearable assistive gloves and verify the improved assistive capability in grasping multiscale objects with irregular geometry, covering a wide weight range (8–559 g) in activities of daily living (ADLs).

What is the optimal initial dose of epinephrine during neonatal resuscitation in the delivery room?

The neonatal resuscitation program recommends a wide dose range of epinephrine for newborns who receive chest compressions (endotracheal tube [ET] dose of 0.05-0.1 mg/kg or intravenous [IV] dose of 0.01-0.03 mg/kg), which presents a challenge to neonatal care providers when attempting to determine the optimal initial dose. Dosing errors are common when preparing epinephrine for neonatal resuscitation. Based on animal data, we suggest preparing 0.1 mg/kg or 1 ml/kg of 1 mg/10 ml epinephrine in a 5 ml syringe for ET administration. For IV epinephrine, we suggest preparing an initial dose of 0.02 mg/kg or 0.2 ml/kg of 1 mg/10 ml epinephrine in a 1 ml syringe. A dose of 0.02 mg/kg enables use of a 1 ml syringe for a wide range of birth weights from 500 g to 5 kg. The use of a color-coded syringe may decrease errors in dose preparation.

Optimal dosing for psilocybin pharmacotherapy: Considering weight-adjusted and fixed dosing approaches.

Background:Growing evidence suggests psilocybin, a naturally occurring psychedelic, is a safe and promising pharmacotherapy for treatment of mood and substance use disorders when administered as part of a structured intervention. In most trials to date, psilocybin dose has been administered on a weight-adjusted basis rather than the more convenient procedure of administering a fixed dose.Aims:The present post hoc analyses sought to determine whether the subjective effects of psilocybin are affected by body weight when psilocybin is administered on a weight-adjusted basis and when psilocybin is administered as a fixed dose.Methods:We analyzed acute subjective drug effects (mystical, challenging, and intensity) associated with therapeutic outcomes from ten previous studies (total N = 288) in which psilocybin was administered in the range 20 to 30 mg/70 kg (inclusive). Separate multivariate regression analyses examined the relationships between demographic variables including body weight and subjective effects in participants receiving 20 mg/70 kg (n = 120), participants receiving 30 mg/70 kg (n = 182), and participants whose weight-adjusted dose was about 25 mg (to approximate the fixed dose that is currently being evaluated in registration trials for major depressive disorder) (n = 103).Results:In the 20 mg/70 kg and 30 mg/70 kg weight-adjusted groups, and in the fixed dose group, no significant associations were found between subjective effects and demographic variables including body weight or sex. Across a wide range of body weights (49 to 113 kg) the present results showed no evidence that body weight affected subjective effects of psilocybin.Conclusions:These results suggest that the convenience and lower cost of administering psilocybin as a fixed dose outweigh any potential advantage of weight-adjusted dosing.

Catalytic SO3 Decomposition Activity of SiO2-Supported Alkaline Earth Vanadates for Solar Thermochemical Water Splitting Cycles

Alkaline earth vanadates (Ae–V: Ae = Ca, Sr, and Ba) were supported on mesoporous SiO2 by a wet impregnation method. The catalytic activity of the prepared materials for the decomposition of SO3 into SO2 and O2, which is a key step in solar thermochemical water splitting cycles, was investigated. In the temperature range 700–800 °C, the Ae–V/SiO2 catalysts exhibited remarkably high activities, which were superior to those of supported Pt catalysts in a wide range of weight hourly space velocities (55–220 g-H2SO4 g–1 h–1). Despite the melting points of the materials exceeding 1000 °C, the high activity was determined to be closely related to the unusual melting behavior of Ae–V. Under the reaction atmosphere, the Ae–V phase was converted to AeSO4 and molten V2O5 (melting point = 690 °C) via facile solid–gas reactions between SO3 and alkaline earth elements displaying high basicity. Notably, upon contact with the molten V2O5 phase, the as-deposited AeSO4 was immediately decomposed into SO2 and O2 to regenerate the Ae–V phase. The catalyst, which solidified at lower temperatures (<690 °C), could not decompose the sulfate and was therefore unable to drive the catalytic cycles. Consequently, the SO3 decomposition rate at <690 °C was lower than that of an alkaline vanadate (Cs–V) with a melting point as low as 500 °C but higher than that of a rare earth vanadate (La–V) with the highest melting point (>1800 °C).

1174. Phase 2 STRIVE Clinical Trial of Rezafungin for Treatment of Candidemia and/or Invasive Candidiasis Demonstrates Consistent Trough Concentrations Across Diverse Patient Populations

BackgroundRezafungin is a novel echinocandin antifungal in development for treatment as well as prevention (prophylaxis) of invasive fungal infections. STRIVE (NCT02734862) is a global, randomized, double-blind, placebo-controlled, Phase 2 trial evaluating safety and efficacy of IV rezafungin once weekly (QWk) for treatment of candidemia and/or invasive candidiasis compared with standard-of-care (IV caspofungin once daily with optional oral stepdown). Here we report pharmacokinetic (PK) data from the completed STRIVE trial analyzed by patient demographics at baseline.MethodsRezafungin Day 8 trough (Cmin) concentrations from patients treated with rezafungin were summarized categorically by race (black or white), sex (male or female), and geographic region (North America [NA], or Europe [EU]), or plotted versus continuous variables of age, body weight, body mass index (BMI), and body surface area (BSA). As the first dose of rezafungin was 400 mg for all rezafungin-treated patients, data from both dose groups (Group 1: 400 mg QWk; Group 2: 400 mg in Week 1 followed by 200 mg QWk) were combined in this analysis.ResultsRezafungin mean Cmin (SD) values were 1.8 (0.7) and 2.3 (1.2) in black and white patients, 1.9 (1.0) and 2.6 (1.2) in males and females, and 1.9 (0.6) and 2.4 (1.3) in patients from NA and EU. There were small differences in point estimates between the groups, but there was a great deal of overlap and the differences are not expected to be clinically meaningful (Figure). Similarly, no trends in Cmin values were observed across a range of ages (20-80 years), weights (~40-155 kg), BMI (~15-65 kg/m2), and BSA (~1.4-2.4 m2).Figure ConclusionNo meaningful differences in rezafungin Cmin values were observed in patients grouped by sex, race, or geographic region, or across a wide range of patient factors, including age and body weight and size. These findings indicate that a single rezafungin dose regimen can be expected to provide consistent PK across diverse patient populations.DisclosuresShawn Flanagan, PhD, Cidara Therapeutics, Inc. (Employee, Shareholder) Christopher M. Rubino, PharMD, Institute for Clinical Pharmacodynamics, Inc. (Employee)Spero Therapeutics (Grant/Research Support) Taylor Sandison, MD, MPH, Cidara Therapeutics, Inc. (Employee, Shareholder)