Wide Regulation Range Research Articles

Epigenetic modulation of doxorubicin resistance and strategies for enhancing chemotherapeutic sensitivity.

With the rising global cancer burden, the dependency on chemotherapy also rises along with the complication of chemoresistance development. Studies on multi-drug resistant proteins provide a wide range of regulators, although the exact mechanism is not yet clearly understood. Epigenetic modifications play a vital role in the regulation of cellular processes and also in determining the efficacy of cancer therapy by modulating resistance development and tumor progression. Of the various epigenetic modifications, histone acetylation/deacetylation and DNA methylation are currently given more focus in evaluating their role in resistance development to doxorubicin. This chapter highlights the various studies conducted on the regulation of doxorubicin (dox) resistance based on these epigenetic modifications and the clinical trials conducted in evaluating its effectiveness as a potential combinational therapy.

Efficiency Analysis and Optimization of Two-Speed-Region Operation of Permanent Magnet Synchronous Motor Taking into Account Iron Loss Based on Linear Non-Equilibrium Thermodynamics

In this article, the linear non-equilibrium thermodynamic approach is used to mathematically describe the energy regularities of an interior permanent magnet synchronous motor (IPMSM), taking into account iron loss. The IPMSM is considered a linear power converter (PC) that is multiple-linearized at operating points with a given angular velocity and load torque. A universal description of such a PC by a system of dimensionless parameters and characteristics made it possible to analyze the perfection of energy conversion in the object. For IPMSM, taking into account iron loss, a mathematical model of the corresponding PC has been built, and an algorithm and research program have been developed, which is valid in a wide range of machine speed regulations. This allows you to choose the optimal points of PC operation according to the maximum efficiency criteria and obtain the efficiency maps for IPMSM in different speed regions. The results of the studies demonstrate the effectiveness of the proposed method for determining the references of the d and q components of the armature current for both the loss-minimization strategy at the constant torque range of motor speed and the flux-weakening strategy in the constant power range.

Multi-Component Lithiophilic Alloy Film Modified Cu Current Collector for Long-Life Lithium Metal Batteries by a Novel FCVA Co-Deposition System.

Surface modification of Cu current collectors (CCs) is proven to be an effective method for protecting lithium metal anodes. However, few studies have focused on the quality and efficiency of modification layers. Herein, a novel home-made filtered cathode vacuum arc (FCVA) co-deposition system with high modification efficiency, good repeatability and environmental friendliness is proposed to realize the wide range regulation of film composition, structure and performance. Through this system, ZnMgTiAl quaternary alloy films, which have good affinity with Li are successfully constructed on Cu CCs, and the fully enhanced electrochemical performances are achieved. Symmetrical cells constructed with modified CCs maintained a fairly low voltage hysteresis of only 13mV after 2100h at a current density of 1mA cm-2. In addition, the capacity retention rate is as high as 75.0% after 100 cycles in the full cells. The influence of alloy films on the dynamic evolution process of constructing stable artificial solid electrolyte interphase (SEI) layer is revealed by in situ infrared (IR) spectroscopy. This work provides a promising route for designing various feasible modification films for LMBs, and it displays better industrial application prospects than the traditional chemical methods owing to the remarkable controllability and scale-up capacity.

Modulation of Wide Voltage Range Interface DC-DC Converter in DC Distribution System

Bipolar DC distribution systems rely on various power sources like photovoltaics and distributed energy storage, each with its unique voltage characteristics. To accommodate these fluctuations, interface converters must adjust over a wide voltage range. The bipolar non-isolated DC-DC converter emerges as a promising solution due to its versatile modulation capabilities, reduced switch voltage stress, and cost-effectiveness. This article explores how wide voltage range regulation is achieved in bipolar DC-DC converters interfacing with bipolar DC power grids. It delves into the operational strategies and modulation techniques employed, ensuring stable output despite varying input voltages. Design considerations and challenges associated with implementing such converters are also discussed. An experimental platform was constructed to validate the proposed methodology. Through rigorous testing and analysis, the effectiveness of the topology's operation mode was confirmed. Real-world data from the experimental setup provided insights into the converter's performance under different operating conditions, supporting its applicability for bipolar DC distribution systems. In summary, this article provides a comprehensive examination of wide voltage range regulation in bipolar DC-DC converters, highlighting their potential to enhance efficiency and reliability in bipolar DC power grids. Through theoretical discussions and practical validation, it contributes to the advancement and adoption of these converters in modern energy systems.

A comparative study of machine learning models with LASSO and SHAP feature selection for breast cancer prediction

In recent decades, breast cancer has become the most prevalent type of cancer that impacts women in the world, which shows a significant risk to the death rates of women. Early identification of breast cancer might drastically decrease patient mortality and greatly improve the chance of an effective treatment. In modern times, machine learning models have become crucial for classifying cancer and strengthening both the accuracy and efficiency of diagnostic and medical treatment strategies. Therefore, this study is focused on early detection of breast cancer using a variety of machine learning algorithms and desires to identify the most effective feature selection process with an amalgamated dataset. Initially, we evaluated five traditional models and two meta-models on separate datasets. To find the most valuable features, the study used the Least Absolute Shrinkage and Selection Operator (LASSO) as well as SHapley Additive exPlanations (SHAP) selection methods and analyzed them through a wide range of performance regulations. Additionally, we applied these models to the combined dataset and observed that the mergeddataset was significantly beneficial for breast cancer diagnosis. After analyzing the feature selection strategies, it was demonstrated that the majority of models performed more accurately when utilizing SHAP methodologies. Notably, three traditional models and two meta-classifiers obtained an accuracy of 99.82%, demonstrating superior performance compared to state-of-the-art methods. This advancement holds a crucial role as it lays the foundation for refining diagnostic tools and enhancing the progression of medical science in this field.

The haplotype-resolved genome of diploid Chrysanthemum indicum unveils new acacetin synthases genes and their evolutionary history.

Acacetin, a flavonoid compound, possesses a wide range of pharmacological effects, including antimicrobial, immune regulation, and anticancer effects. Some key steps in its biosynthetic pathway were largely unknown in flowering plants. Here, we present the first haplotype-resolved genome of Chrysanthemum indicum, whose dried flowers contain abundant flavonoids and have been utilized as traditional Chinese medicine. Various phylogenetic analyses revealed almost equal proportion of three tree topologies among three Chrysanthemum species (C. indicum, C. nankingense, and C. lavandulifolium), indicating that frequent gene flow among Chrysanthemum species or incomplete lineage sorting due to rapid speciation might contribute to conflict topologies. The expanded gene families in C. indicum were associated with oxidative functions. Through comprehensive candidate gene screening, we identified five flavonoid O-methyltransferase (FOMT) candidates, which were highly expressed in flowers and whose expressional levels were significantly correlated with the content of acacetin. Further experiments validated two FOMTs (CI02A009970 and CI03A006662) were capable of catalyzing the conversion of apigenin into acacetin, and these two genes are possibly responsible acacetin accumulation in disc florets and young leaves, respectively. Furthermore, combined analyses of ancestral chromosome reconstruction and phylogenetic trees revealed the distinct evolutionary fates of the two validated FOMT genes. Our study provides new insights into the biosynthetic pathway of flavonoid compounds in the Asteraceae family and offers a model for tracing the origin and evolutionary routes of single genes. These findings will facilitate in vitro biosynthetic production of flavonoid compounds through cellular and metabolic engineering and expedite molecular breeding of C. indicum cultivars.

Comprehensive analysis of human monocyte subsets using full-spectrum flow cytometry and hierarchical marker clustering.

Exploring monocytes' roles within the tumor microenvironment is crucial for crafting targeted cancer treatments. This study unveils a novel methodology utilizing four 20-color flow cytometry panels for comprehensive peripheral immune system phenotyping, specifically targeting classical, intermediate, and non-classical monocyte subsets. By applying advanced dimensionality reduction techniques like t-distributed stochastic neighbor embedding (tSNE) and FlowSom analysis, we performed an extensive profiling of monocytes, assessing 50 unique cell surface markers related to a wide range of immunological functions, including activation, differentiation, and immune checkpoint regulation. This in-depth approach significantly refines the identification of monocyte subsets, directly supporting the development of personalized immunotherapies and enhancing diagnostic precision. Our pioneering panel for monocyte phenotyping marks a substantial leap in understanding monocyte biology, with profound implications for the accuracy of disease diagnostics and the success of checkpoint-inhibitor therapies. Key findings include revealing distinct marker expression patterns linked to tumor progression and providing new avenues for targeted therapeutic interventions.

Moslae Herba: Botany, Traditional Uses, Phytochemistry, and Pharmacology.

Moslae Herba (MH) can be used for both medicine and food and has a long history of medicine. MH has the effects of sweating and relieving the exterior, removing dampness and harmonizing, and is mainly used for colds caused by damp heat in summer. It is called "Xiayue Zhi Mahuang" in China. So far, 123 chemical compounds have been isolated and identified from MH, including flavonoids, terpenoids, phenolic acids, phenylpropanoids, and other chemical compounds. Its chemical components have a wide range of pharmacological activities, including antibacterial, antiviral, anti-inflammatory, antioxidant, analgesic sedation, antipyretic, immune regulation, insecticidal, and other effects. In addition, because of its aromatic odor and health care function, MH also has development and utilization value in food, chemical, and other fields. This paper reviewed the research progress of MH in botany, traditional uses, phytochemistry, and pharmacology and provided a possible direction for further research.

Enhancing Thermal Performance of Thermodynamic Cycle through Zeotropic Mixture Composition Regulation: An Overview

Composition regulation of zeotropic mixture working fluid for a thermodynamic cycle is an effective way to improve energy conversion efficiency, which offers the potential to construct efficient, flexible and intelligent cycles. Current research on cycle construction of zeotropic mixture composition regulation still heavily relies on construction methods using pure working fluids, where the characteristics of flexible composition variations fail to be utilized. In this paper, the research progress of cycle construction methods and composition regulated structures are comprehensively reviewed, aiming to clarify the potential for enhancing a thermodynamic cycle based on composition regulation. The characteristics of different cycle construction methods are firstly summarized and compared. Then, the composition-regulated structures of a physical-based method and chemical-based method are introduced, and the composition regulation performance are also concluded. Finally, a future outlook on the cycle design and structure design is provided. The review results show that the combination of 3D construction method and superstructure/intelligences construction method has the potential to maximize the cycle performance, where the improvement of each thermal process and the optimization of complex cycles can be considered simultaneously. The composition regulation based on a passive physical method has the advantage of being readily applicable; however, the composition regulation range is limited. In addition, the distillation and hydrate method have a wider regulation range through extra energy input, where the trade-off between energy consumption and cycle performance improvement should be considered in the future. This study greatly assists in the design of thermodynamic cycles involving zeotropic mixture composition regulation and the corresponding composition regulation structures.

A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression invivo.

HMG (high mobility group) proteins are a diverse family of nonhistone chromosomal proteins that interact with DNA and a wide range of transcriptional regulators to regulate the structural architecture of DNA. HMGXB4 (also known as HMG2L1) is an HMG protein family member that contains a single HMG box domain. Our previous studies have demonstrated that HMGXB4 suppresses smooth muscle differentiation and exacerbates endotoxemia by promoting a systemic inflammatory response in mice. However, the expression of Hmgxb4 invivo has not fully examined. Herein, we generated a mouse model that harbors a gene trap in the form of a lacZ gene insertion into the Hmgxb4 gene. This mouse enables the visualization of endogenous HMGXB4 expression in different tissues via staining for the β-galactosidase activity of LacZ which is under the control of the endogenous Hmgxb4 gene promoter. We found that HMGXB4 is widely expressed in mouse tissues and is a nuclear protein. Furthermore, the Hmgxb4 gene trap mice exhibit normal cardiac function and blood pressure. Measurement of β-galactosidase activity in the Hmgxb4 gene trap mice demonstrated that the arterial injury significantly induces Hmgxb4 expression. In summary, the Hmgxb4 gene trap reporter mouse described here provides a valuable tool to examine the expression level of endogenous Hmgxb4 in both physiological and pathological settings invivo.

Legal Protection of Women’s Rights in Afghanistan During the Taliban Regime of 2021-2022 and the State Responsibility

This paper discusses women’s rights in Afghanistan during the Taliban regime from 2021 to 2022. Having seized power in Afghanistan by the Taliban in August 2021, a wide range of regulations seem to discriminate against women. The discriminatory restrictive regulations enforced by the Taliban have prevented women and girls in Afghanistan from receiving the same rights as men, such as access to education, employment, and access to public facilities. This is clearly inconsistent with The Convention on the Elimination of All Forms of Discrimination Against Women (CEDAW). Given that Afghanistan ratified CEDAW in 2003, it guarantees the protection of women’s rights, it means that Afghanistan has become a state party, then Afghanistan has the responsibility to comply with this convention. This research uses the type of normative legal research - searching for material in the form of library materials or secondary data as sources in writing research. The purpose of this study is to find out how the legal protection of women’s rights during the Taliban regime considering that Afghanistan has ratified CEDAW. Furthermore, to find out whether Afghanistan can be held responsible for the restrictions on women’s rights imposed by the Taliban. The approach used in this study is the conceptual approach and the statute approach. This research also uses a historical approach and a case approach. This study finds the legal protection that Afghanistan has provided for women’s rights based on the ratification of CEDAW, namely the Law on Elimination of Violence against Women (EVAW). The Islamic Republic of Afghanistan’s Constitution also protects women’s rights. However, the EVAW law has not been enforced at all since the Taliban took over. It indicates that Afghanistan can be held responsible.

Study on the separation and mixing laws of wide-grained dense medium in vibration separation fluidized bed

Vibro-fluidized dry coal beneficiation involves the unavoidable mixing of −1 mm coal dust into a fluidized bed, which compromises the stability and homogeneity of the bed density and reduces the effectiveness of fine-grained coal separation. To understand the features of coal powder separation and mixing (-1 mm) in a vibrating fluidized bed, as well as to achieve a uniform and stable bed density, a wide-grained dense medium consisting of −1 mm coal dust and 0.3–0.15 mm magnetite powder was homogeneously mixed in this work. The degree of density separation in the entire bed and the local mixing properties of the wide-grained dense medium were examined. It was discovered that when low vibrational energy was introduced at the same air velocity, particle separation was enhanced compared to the usual fluidized bed. Small bubbles were found to ensnare fine coal dust and migrate upwards, increasing the density separation. The introduction of high vibrational energy led to particle disorder within the bed and an increase in the level of particle mixing. The beneficial effects of the vibration on the bed diminished when the air velocity was gradually increased under the specified vibration conditions. This caused large bubbles to develop more frequently, which increased particle mixing. The 1–0.5 mm fine-grained coal exhibited the best mixing state; it was less affected by variations in air velocity and vibration levels, whereas the −0.5 mm coal dust was more affected by each variable. Furthermore, the particle system achieved a wide range of air velocity regulations without a significant segregation state change under the vibration conditions of f= 25 Hz and A=1 mm and f= 25 Hz and A=2 mm.

Plague, Religion and Urban Space in Sixteenth-Century Antwerp.

Antwerp's response to the outbreak of plague in the 1570s offers new insights into the effects of epidemics on urban communities in relation to their religious, economic, and spatial fabric. Antwerp's transition from a Catholic to Calvinist government in 1577, and back to Catholicism in 1585, allows us to study its reaction to and the effects of plague across religious boundaries within a short time span. Using GIS, we have compared various rich datasets concerning plague: the register of houses locked in quarantine; the health certificates issued by authorities; plague fatalities recorded in St. Jacob's parish; a wide range of urban regulations; and information about the size of households, their composition, rents and real estate values in Antwerp. Combined analysis shows that Catholics and Protestants, whose houses were concentrated in different city districts and who had distinct professional and economic profiles, experienced plague quite differently, both physically and spiritually.

Modification of the surface of titanium alloys by the synthesis of coatings by the PEO method in alkaline electrolytes saturated with diatomite

One of the most promising directions of modern materials science is the search for methods of improving the biocompatibility properties of metals used in implantology, which will allow to reduce the percentage of rejection of implants by the living organism. Therefore, it is promising to use processing methods to change the state of the surface of metals due to surface modification, which includes the method of plasma electrolytic oxidation. The main goal of this work was to develop a technological process for obtaining coatings with higher biocompatibility compared to the base metal due to the introduction of natural components into the coating. The presence of elements in biocoatings and their quantity was determined using a scanning electron microscope (SEM) and energy dispersive X-ray spectroscopy (EDS), which allowed for targeted analysis of the surface of the samples. The elemental composition of coatings synthesised on the basis of titanium alloy in alkaline electrolytes based on KOH, liquid glass of calcium hydroxide, sodium polyphosphate and sodium pyrophosphate with the addition of hydroxyapatite and diatomite was researched in the work. A direct relationship between the composition of the electrolyte and the Ca/P ratio was established. It has been proven that biocoatings synthesised in alkaline solutions by the PEO method satisfy the conditions of biocompatibility. It has been established that in an environment containing alkalis and phosphates, coatings are synthesised for which Ca/P = 1.21. The introduction of hydroxyapatite into the electrolyte leads to an increase in the Ca/P ratio to a value of 1.28, and an increase in the concentration of the electrolyte and the addition of diatomite increases this ratio to a value of 1.57. The obtained results establish the possibility of a wide range of regulation of the Ca/P ratio in the biocoating

Labor Market Institutions and Employment

The role of labor market institutions and policies has received great attention throughout the history of labor economics. Labor market institutions are responsible for a wide range of policies, regulations, and organizations that affect the labor market, though their impact on employment can vary depending on the specific institutions and the economic context across countries. This entry attempts to provide an overview of five main labor market institutions and policies, i.e., the minimum wage, employment protection, the power of unions, active labor market policies, and unemployment insurance/unemployment benefits. It also presents theoretical expectations of their effects on employment outcomes and collates relevant results from the related literature, focusing mainly on the most recent empirical evidence. Finally, this entry provides insights regarding labor market institutions and offers proposals for shaping the labor market landscape.

Environmental Aspects of Using Fire Protection Systems With a Sustainable Development Approach

Waste management is an increasingly important issue and challenge in our world today, which must be one of the foundations of sustainable development in such special areas too as the installation and maintenance of built-in fire alarm and extinguishing systems. These devices are now widespread, not only for the protection of ‘critical systems and facilities’, but also for protection of simpler facilities. In addition to the manufacture of these devices, their installation, maintenance and disposal also have many environmental aspects that need to be carefully considered in order to avoid unnecessary pollution. Hungarian experience shows that the handling of the various materials used in built-in fire protection systems is individually well regulated, but due to the wide range of regulations, it is difficult for the involved contractors and operators to apply it. Therefore, one of the keys to achieving effective waste management is the information of those involved. The systematisation and simplified communication of information on waste management and tasks can increase the efficiency of the contractors’ compliance, related to their special work. With this article we would like to contribute to sustainable development. The best first little step to inform the relevant professionals is to create a well-structured, easy-to-interpret table containing the most important related environmental protection tasks and information.

Determination of the design features of the device for neutralizing toxic components of flue gases

The influence of the boiler unit load on the area of heterogeneous reactions of the process of catalytic flue gas purification is considered. The optimal geometric characteristics of the neutralizer monolith were determined when the steam capacity of the TGME-464 boiler unit varied from 220 to 500 t/h. The calculations were performed using a mathematical model for the conditions of the operating power equipment. The optimal size of the unit cell of the catalyst block is determined in a wide range of boiler load regulation. The data obtained as a result of the study formed the basis for designing a sample of an industrial neutralizer of toxic flue gas components without the introduction of an external reagent.

On‐board charger applications: A new hybrid control strategy for bidirectional CLLC resonant converter

AbstractThis paper proposes a new hybrid control strategy to solve the problem of bidirectional wide voltage range regulation in CLLC converters. On the (LLC) side (G2V direction), the SSSA control method is employed for voltage boost, combined with bus voltage and burst control to achieve wide voltage regulation. On the (C) side (V2G direction), the SSSA and full/half‐bridge mode switching control are used to achieve V2G direction wide voltage regulation. This hybrid control strategy also enables high conversion efficiency in both directions without the need for additional components to reduce the converter power density. This is particularly suitable for OBC applications with strict requirements for converter volume and weight. A detailed analysis with mathematical derivation, hybrid control strategy, and converter operation principles is introduced in this paper. The following subchapters supplement the converter voltage gain, soft switching implementation conditions, and design considerations. Finally, the feasibility of the proposed control strategy was verified through an experimental prototype with an input voltage ranging from 340 to 430 V to an output voltage ranging from 225 to 450 V and bidirectional rated power of 6.6/3.3 kW. This prototype achieved a maximum conversion efficiency of 97.7% in the G2V direction and 97.1% in the V2G direction.

МИКРОПРОЦЕССОРНАЯ СИСТЕМА РЕГУЛИРОВАНИЯ МОЩНОСТИ ИНДУКЦИОННОЙ НАГРЕВАТЕЛЬНОЙ СИСТЕМЫ НА ОСНОВЕ ПЛОТНО-ИМПУЛЬСНОЙ МОДУЛЯЦИИ

Relevance Oil production, storage, transportation and refining often require accompanying heating processes with careful control of input and output parameters. The most effective heating technology in oil production, refining and pipeline transportation complexes is induction heating. The specifics of oil heat treatment involve maintaining a certain temperature regime, which reduces its viscosity to the required level, while preventing coking. Induction heating technology allows regulating the output power, and therefore the heating temperature, in wide ranges (1–100 %), which allows maintaining a given temperature regime of action on oil. The use of a resonant mode for induction heating systems is energetically efficient. One of the methods for regulating the power of resonant systems is densepulse modulation, which ensures the maintenance of a resonant mode and a wide range of system regulation. Aim of research Develop an algorithm for the operation of a modulator that allows reducing the amount of memory occupied on the microcontroller and controlling the heating power of an induction heating unit. Research methods The following methods were used in this study: mathematical modeling, principles of signal modulation, computer modeling of the operation of a pulse-dense modulator. Results A dense-pulse modulation circuit has been created on the AVR microcontroller ATmega328, as well as a program code for the dense-pulse modulator circuit.

Research and design of an efficient adaptive drive with balancing friction coupling

Currently, research related to the automation of processes, systems and devices are of high relevance in the scientific and technical field: in the aerospace industry, robotics and electric transport technology. Successful automation of facilities and processes requires simplified control systems, and an adaptive mechanical system operates without a control system, which increases its reliability and efficiency. In particular, the creation of an efficient and reliable transmission of electric autonomous and mobile vehicles can be achieved by an adaptive mechanical drive with two degrees of freedom. Adaptation of the two-mobile system (2-DoF) is achieved by the proposed completely new type of transmission, namely the design of a stepless multi-speed drive with an additional friction coupling. The property of reliable adaptation of a two-mobile self-adjusting mechanical drive is independent adaptability to an external load with the help of a balancing friction coupling that provides a connection between the frictional moment and the relative angular velocity. The article presents a study of the interaction of the parameters of a two mobile system in order to improve the efficiency of a self-adjusting adaptive drive with a given wide range of regulation based on the use of a friction coupling.