WHOQOL Scores Research Articles

Efficacy and safety of hepatic artery infusion chemotherapy with mFOLFOX in primary liver cancer patients with hyperbilirubinemia and ineffective drainage: a retrospective cohort study.

BackgroundHyperbilirubinemia is a major barrier to anti-tumor treatment in patients with end-stage primary liver cancer. However, no research has demonstrated the efficacy and safety of hepatic artery infusion chemotherapy (HAIC) in primary liver cancer patients with hyperbilirubinemia. This study investigated HAIC with a modified oxaliplatin, fluorouracil, and leucovorin (mFOLFOX) regimen. The efficacy and safety of the treatment regimen was evaluated and the optimal conditions for further anti-tumor treatments were identified.MethodsA total of 34 patients with hyperbilirubinemia (with an elevation of more than three times the upper limit of normal range in total bilirubin) who were not candidates for surgery, transplantation, tyrosine kinase inhibitor therapy, nor immune checkpoint inhibitor (ICI) therapy, and who received HAIC with the mFOLFOX regimen were enrolled in this study. The laboratory indexes (total bilirubin, tumor markers, and blood count), quality of life [World Health Organization Quality of Life (WHOQOL)-100 score], adverse reactions [Common Terminology Criteria for Adverse Events (CTCAE)-5.0], and overall survival were analyzed.ResultsBetween June 2017 and January 2021, 34 patients received a total of 81 cycles of HAIC after percutaneous transhepatic biliary drainage (PTBD). The total bilirubin (TBIL) decreased significantly at 1 month after the last cycle of HAIC (127.8 vs. 68.3 µmol/L; P<0.01). There was no significant decrease in platelet, white blood cell, nor red blood cell counts, suggesting that HAIC had limited toxicity on the hematopoietic system. The WHOQOL-100 score significantly increased at 3 months after HAIC (78.16 vs. 69.26; P<0.05). The median overall survival was 9.5 months (range, 2–24 months), the objective response rate was 14.7%, and the disease control rate was 61.8% in HAIC-treated patients. A total of 14 patients received targeted or immunological therapy after HAIC, and 2 of these patients achieved complete remission.ConclusionsHAIC improved the liver function and the quality of life in patients with liver cancer and hyperbilirubinemia, which provided options for further anti-tumor treatments in such patients.

PREVALENCE OF KNEE OSTEOARTHRITIS AND QUALITY OF LIFE AMONG MIDDLE AGED ADULTS OF PAKISTAN

Background: Osteoarthritis (OA) is a common and disabling constant Musculoskeletal Disorder that causes significant weight on individual, Health Care Systems, and social economy. With the maturing of the populace and the commonness of undesirable way of life practices, the predominance and disease burden of OA are expanding day by day. Objective: To find the prevalence of knee osteoarthritis and quality of life among middle-aged adults. Methodology: A descriptive cross-sectional survey was conducted at the major hospitals and physical therapy clinical setups of Pakistan from April to July 2019 (4 months) after approval of IRB/ERC (SRMCH/MS/20/12/41) Suleman Roshan medical college hospital, Tando Adam. The total sample was n=300 selected using non-probability convenience sampling. The middle-aged adults (40-65 years) having moderate to severe knee pain, both male and female were included. According to the American college of rheumatology the criteria for assessing OA by using history, physical examination, and radiographic findings: pain in the knee and one of following over 50 years of age, less than 30minutes of morning stiffness crepitus on active motion and osteophytes and quality of life assessed according to WHOQOL-100 score. The results of the study are presented as frequency, percentages, and mean ±SD. The data were analysed through SPSS 21.Results: The mean age of the study participants (n=300) was a 48.96±6.804 year. The majority of the participants were female (n=208) and the remaining n=92 were male. The prevalence of OA in the middle aged adults (n=300) n=170 (56.7%). The significantly reduced QoL among patient having knee OA (37.19±23.22 ver 42.51±22.69, p&lt;0.05) as compare to those having knee pain without Knee OA.Conclusion: The prevalence of knee pain in middle-aged adults is high and their quality of life is moderately affected. Key words: Knee, Middle-aged, Osteoarthritis, Prevalence, Quality of life.

The Efficacy of a Smartphone-Based App on Stress Reduction: Randomized Controlled Trial.

BackgroundStress management in the workplace is essential for a healthy mental and physical state. Due to technological advancements, individually tailored therapy and online cognitive behavioral therapy (CBT) are on the rise.ObjectiveThis study analyzed the efficacy of a smartphone app based on third-wave CBT tailored to an individual.MethodsA randomized controlled trial was conducted with 126 participants who were divided into 2 groups. The intervention group used the smartphone app BetterLife for 10 weeks, while the control group was placed on a waiting list for the same duration. The Perceived Stress Scale–10 (PSS), Korean Utrecht Work Engagement Scale–9 (UWES), World Health Organization Quality of Life Assessment (WHOQOL), Beck Depression Inventory–II (BDI), and Beck Anxiety Inventory (BAI) were administered at baseline and after 10 weeks to both groups.ResultsOf the 126 participants, 11 dropped out during the trial. A 2-way repeated measure analysis of covariance was conducted, controlling for baseline BDI. There were greater improvements in PSS (F=24.33, P<.001, η2=0.17) and UWESK scores (F=8.32, P=.0046, η2=0.06) in the intervention group than in the control group. WHOQOL scores exhibited statistically significant improvement in the intervention group in the overall quality of life (F=8.19, P=.0049, η2=0.06), physical health (F=8.87, P=.003, η2=0.07), psychological health (F=13.32, P<.001, η2=0.10), social relationships (F=19.43, P<.001, η2=0.14), and environmental domains (F=10.14, P=.002, η2=0.08) but not overall health (F=1.68, P=.20). BDI (F=7.17, P=.008, η2=0.06) and BAI (F=6.00, P=.02, η2=0.05) showed a statistically significant improvement in the intervention group, but this significance did not survive the Bonferroni correction (P<.005).ConclusionsThese results provide evidence that smartphone-based CBT is a viable option for reducing stress in the workplace.Trial RegistrationClinical Research Information Service KCT0003231; https://cris.nih.go.kr/cris/search/detailSearch.do/15137

Effect of Physiotherapy on Hand Rehabilitation in Acute Ischemic Stroke Survivor: A Case Report

Background: Ischemic injury to the brain caused by a sudden drop in blood supply causes over 80% of strokes. Large artery blockage occurs in about 25-35 percent of strokes, and patients in this category often have severe neurological impairments. The prognosis is bleak if treatment is not started right away. Imaging of the brain after a stroke is crucial for determining the extent of tissue damage and guiding treatment.&#x0D; Aim: To determine the effect of early hand rehabilitation post ischemic stroke.&#x0D; Presentation of Case: A 35-year-old woman with a history of hypertension acquired aphasia, left hemiplegia, and hemisensory loss all at the same time. She was sent to the hospital's emergency room. On CT the blockage of the right middle cerebral artery revealed an acute ischemic stroke. The Motor Assessment Scale is taken in which there is a hand function domain also to assess it.&#x0D; Discussion: There are many studies on hand rehabilitation, but usually we stated hand rehabilitation late. Our primary focus during rehabilitation is upper limb and lower limb, hand is a little neglected part.&#x0D; So, in this case study we will be focusing on early had rehabilitation.&#x0D; Conclusion: The case data confirms a diagnosis and appropriately planned physical rehabilitation care that resulted in a progressive improvement on STREAM Score, Motor Assessment Scale Score, Barthal index score and WHO-QOL score.

General health Status and Tridosha analysis of urban high-risk Diabetes after 3-month Diabetes Yoga Protocol: a pilot study

Background and Purpose: Stress and anxiety have been closely related with insulin resistance, early appearance of diabetes and enhanced diabetes progression. Stress and anxiety also have negative effect on patients’ general health status and quality of life. In earlier study Yoga has been proven as an effective intervention for prevention, treatment, risk reduction of diabetes, and prevent conversion from prediabetes to diabetes and reduce diabetes complication. The present study was aimed to identify the diabetes high risk population and to analyze the effect of 3-month DYP on General health, anxiety, quality of life and Tridosha in urban high risk for diabetes population. Method: Total 12 participants were selected for present study on the basis of inclusion and exclusion criteria and screened through IDRS scale. Five participant were included in the study based on IDRS score (?60). General health, quality of life, State and Trait Anxiety and Tridosha were measured at baseline and after 3 months of Diabetes Yoga Protocol by self-administrated questionnaire. Result: Results showed significant reduction in STAI (p = .001***) and significant improvement in GHQ-12 (p = 0.022*), Physical health (p = 0.018*), Psychological health (p = 0.000***), Environment (p = 0.000***), Total WHOQOL (p = 0.001***), Vata (p = 0.007**), Pitta (p = 0.032*) and total Tridosha (p = 0.002**) score after 3-month of DYP. Conclusion: DYP may helpful for general health, quality of life and reduce anxiety level and Tridosha score in urban high risk for Diabetic population.

A Botanical Product Containing Cistanche and Ginkgo Extracts Potentially Improves Chronic Fatigue Syndrome Symptoms in Adults: A Randomized, Double-Blind, and Placebo-Controlled Study.

Dietary therapy may be beneficial in alleviating symptoms of chronic fatigue syndrome (CFS), a disorder that is characterized by extreme fatigue and other symptoms, but the cause of which remains unclear. The aim of this study was to evaluate the protective effect of a botanical product containing cistanche (Cistanche tubulosa [Schenk] Wight) and ginkgo (Ginkgo biloba L.) extracts on adults with CFS in a randomized, double-blind, placebo-controlled clinical trial. A total of 190 subjects (35–60 years old, non-obese) with CFS were randomized to receive one tablet of a low dose (120-mg ginkgo and 300-mg cistanche), a high dose (180-mg ginkgo and 450-mg cistanche) or a placebo once daily for 60 days. Blood samples and responses on the Chalder fatigue scale (CFQ 11), the World Health Organization's quality of life questionnaire (WHOQOL), and the sexual life quality questionnaire (SLQQ) were collected at baseline and post-intervention. CFS symptoms of impaired memory or concentration, physical fatigue, unrefreshing sleep, and post-exertional malaise were significantly improved (p < 0.001) in both of the treatment groups. The botanical intervention significantly decreased physical and mental fatigue scores of CFQ 11 and improved WHOQOL and SLQQ scores of the subjects (p < 0.01). Levels of blood ammonia and lactic acid in the treatment groups were significantly lower than those of the placebo group (low-dose: p < 0.05; high-dose: p < 0.01). In addition, the change in lactic acid concentration was negatively associated with the severity of CFS symptoms (p = 0.0108) and was correlated with the change in total physical fatigue score of the CFQ (p = 0.0302). Considering the trivial effect size, the results may lack clinical significance. In conclusion, this botanical product showed promising effects in ameliorating the symptoms of CFS. Clinical trials with improved assessment tools, an expanded sample size, and an extended follow-up period are warranted to further validate the findings.Clinical Trial Registration: https://clinicaltrials.gov/, identifier: NCT02807649.

Association of patient quality of life with the degree of agreement in the perceptions of patient disability within the stroke patient–rehabilitation therapist dyad: a cross-sectional study in postdischarge rehabilitation setting

ObjectivesThe purpose of study was to explore the association between patient physical and psychological quality of life (QOL) with the degree of agreement in perceptions of patient disability within the...

Height and quality of life among older adults (50+) in India: a cross-sectional study.

Adult height is a summary measure of health and net nutrition in early childhood. This study examines the association between height and quality-of-life outcomes in older adults (50+) in India. Cross-sectional data from Wave 1 of the World Health Organization (WHO) Study on global AGEing and adult health (SAGE) conducted in 2007 were analysed. The association between height and quality of life was assessed using bivariate and multivariate logistic and linear regression models. The mean WHO quality-of-life score (WHO-QoL) increased from 45.2 among the older adults in the lowest height quintile to 53.2 for those in the highest height quintile. However, the prevalence of self-rated poor quality of life declined from 16.4% in the lowest height quintile to 6.1% in the highest height quintile. In the fully adjusted regression model, height was found to be positively associated with quality-of-life outcomes among both men and women, independent of socioeconomic and physical health confounders. The association was particularly strong for women. Women in the highest height quintile had a 2.65 point higher WHO-QoL score than those in the lowest height quintile. Similarly, the likelihood of reporting a poor quality of life was lower among women in the highest height quintile. Furthermore, measures of economic status, handgrip strength, cognitive ability and poor self-rated health were significantly associated with WHO-QoL and self-rated poor quality of life. Overall, this study revealed a significant association between height and quality of life among older adults in India, suggesting a significant role of childhood circumstances in quality of life in later life.

FACTORS ASSOCIATED WITH PSYCHOLOGICAL OUTCOMES OF HEALTHCARE WORKERS DURING THE COVID-19 PANDEMIC AND ITS EFFECTS ON QUALITY OF LIFE

Purpose: This study aimed at assessing the factors associated with psychological outcomes among HCWs in Saudi Arabia (SA) during the pandemic. It also aims to determine the factors affecting their QoL.&#x0D; Methodology: In this descriptive cross-sectional study, all HCWs who are working in direct and indirect contact with COVID-19 cases in tertiary hospitals of SA were invited voluntarily to complete the validated web-based survey during the study period. A total of 1,182 HCWs from different regions across SA and different specialties including physicians, nurses, pharmacists, health educators, technicians, and others responded to this study between the 1st of June and the 31st of July 2020. Psychological risk factors were evaluated using Patient Health Questionnaire depression scale; and the Generalized Anxiety Disorder (GAD-7) anxiety scale. QoL was assessed using the World Health Organization Quality of Life Questionnaire (WHOQOL). Socio-demographic data were summarized with frequency and percentages. The overall anxiety, depression, WHOQOL scores of the study participants were calculated according to mean value, SD, and median. The association between socio-demographic factors and anxiety, depression scales were examined using independent samples t-tests, one-way ANOVA, and the chi-square test (for categorical depression/ anxiety variables severe depression/severe anxiety against mild/moderate/moderately severe). While those factors and WHOQOL domains were examined using one-way ANOVA. Multivariate analysis was used to identify the front-line work predictors of depression and anxiety.&#x0D; Findings: Poor QoL scores were observed, especially in the physical and psychological health domains. In general, low QoL was significantly higher among workers who reported higher levels of anxiety and depression. The observed factors affecting the psychological health and QoL were age, gender, living with children and/or older people, occupation, years of experience, participation in front-line work.&#x0D; Unique contribution to theory, practice and policy: Specific characteristics of HCWs may act as protective or risk factors with regard to depression, anxiety, and QoL. Targeted interventions could mitigate the negative effects of front-line work to maintain medical professionals’ optimal psychological and physical health .More research is needed to further determine how the COVID-19 pandemic and front-line work affect HCWs' mental and physical well-being

Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes.

Quality of Life Outcomes Following Single-stage Laparoscopic Common Bile Duct Exploration Versus 2-stage Endoscopic Sphincterotomy Followed by Laparoscopic Cholecystectomy in Management of Cholelithiasis With Choledocholithiasis.

With various studies in the literature showing laparoscopic common bile duct (CBD) exploration to have equal or similar results when compared with endoscopic sphincterotomy (EST) clearance, decision-making in regard to the treatment modality to be used may become debatable. Thus, quality of life (QoL) data may assist both the patient and the clinician in deciding the management of the disease. The present prospective randomized trial was undertaken to compare QoL of patients undergoing treatment with these 2 approaches. The study was conducted March 1, 2013, to September 31, 2016. Consecutive patients with CBD stones were randomized to either laparoscopic CBD exploration with cholecystectomy (group I) and EST followed by laparoscopic cholecystectomy (group II). Diagnosis was confirmed preoperatively using magnetic resonance cholangiopancreatography and/or endoscopic ultrasound. QoL scores were assessed by World Health Organization Quality of Life-Brief Version (WHOQOL-BREF), European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire C30 (EORTC QLQ-C30), and Hospital Anxiety and Depression Scale (HADS) questionnaires. A total of 77 patients with concomitant gallstones and CBD stones were finally recruited (38 patients in group I and 39 patients in group II). The demographic and clinical profiles were similar in both the groups. On EORTC QLQ-C30 questionnaire, there was significant improvement in physical, emotional, and role functioning in both the groups (P<0.01) with no intergroup variation preprocedure or postprocedure. Patients in both the groups reported similar WHOQOL scores with significant improvement postprocedure and minimal intergroup variation. Both the depression and anxiety scores on HADS were comparable between the 2 groups preoperatively and at 3 months postoperatively. Single-stage management of patients with gallbladder and CBD stones and EST followed by laparoscopic cholecystectomy were similar in terms of improvement in QoL.

Care Burden and Quality of Life in Family Caregivers of Palliative Care Patients

This research was conducted for the purpose of examining the care burden and quality of life in family caregivers of palliative care patients. The research design was a descriptive correlational study conducted with the caregivers of 163 patients residing in palliative care units. Data were collected via a demographic survey, The Zarit Burden Interview (ZBI) and the World Health Organization Quality of Life Assessment (WHOQOL). The results showed that there was a negative correlation between ZBI and WHOQOL scores. Further, there was a significant negative correlation between many subdimensions of the ZBI (general quality of life, general perception of health, being satisfied with daily life skills, home conditions, energy and self-satisfaction) and the WHOQOL. Quality of life thus appeared to be reduced in family members with a high level of care burden and that the quality of life of caregivers depends on the individual characteristics of the caregiver. Social workers, nurses and physicians should regularly assess the burden and quality of life of caregivers.

Impact of Sleep Disturbances on the Quality of Life Among Schizophrenic Out-patients of Jimma University Medical Center, Southwest Ethiopia: Hospital Based Cross-sectional Study

Aim: Current study was aimed to assess the impacts of sleep disturbances on patient’s quality of life. Background: Schizophrenia is a syndrome, which affects sleep. Up to 80% of schizophrenic patients complain of sleep disturbances which affect the quality of life Objectives: To assess the association of sleep disturbances and quality of life and other contributing factors among schizophrenic patients on follow-up treatment at Jimma University Southwest Ethiopia. Methods: A cross-sectional study with a consecutive sampling of 411 out-patients at Jimma University medical center was employed from April 21-June 20, 2019. Sleep disturbances and the quality of life were assessed by Pittsburgh sleep quality index and WHOQOL-BREF, respectively. Epi data version 3.1 and SPSS version 23.0 software was used. Chi-square and independent samples t-test were used for association and P-value &lt; 0.05 was considered for statistical significance. Results: Most participants had sleep disturbances and the mean score of positive scale on PANSS was higher for patients with sleep disturbances. About one-fourth of the patients had very good subjective sleep quality and &gt; 85% of sleep efficiency was reported by 139 participants. More than half (51.1%) of the subjects had used sleep medication and the majority (64.7%) of them were reported daytime dysfunctions in the past month. The social domain (M±SD=3.92±2.51, t=8.46, p= &lt;0.001, eta2=0.15) and overall WHOQOL (M±SD=57.60±16.87, t=9.24, p= &lt; 0.001, eta2= 0.17) score had a large difference of means and about 15% and 17% of the variance in sleep disturbance have been explained. Conclusion: Generally, the finding of the current study was in agreement with most of the previous studies and sleep disturbances respectively moderate to significant effects on the patient’s quality of life.

Dyadic Agreement in the Perceptions of Patient Disability Between the Stroke Patient and Rehabilitation Therapist

Research supports that an agreement about the consequences of the illness within related parties is critical for optimal patient outcomes. This study aimed to explore the association between patient QOL and the degree of agreement in the perceptions of patient disability within the stroke patient-rehabilitation therapist dyad. A cross-sectional study was conducted in Japan from March 2019 to February 2020. A total of 81 dyads consisting of a male stroke patient living at home and the therapist in charge of the eligible patient participated. Patient QOL was measured using the WHOQOL BREF. Perceptions of patient disability were measured using the 12-item WHO Disability Assessment Schedule 2.0 (DAS). DAS scores of patients and therapists were classified into two (high, low) and three (high, medium, low) categories, respectively, and six patterns of agreement on patient ability were created to use in the analysis. Generalized estimating equations were used to examine multivariable associations between the degree of agreement within dyad and WHOQOL scores in patients. Results suggested that when the patient appraised himself as having a low disability, the degree of patient-therapist disagreement was negatively associated with patient QOL. When the patient appraised himself as having a high disability, his QOL was lower, regardless of the degree of agreement. Disagreements in the perception of disability between patients and therapists can worsen patient QOL, especially when the patient perceives himself as having a low disability.

Positive effects of resilience and self-efficacy on World Health Organization Quality of Life Instrument score among caregivers of stroke inpatients in China.

Stroke is one of the major health challenges affecting life expectancy and quality of life around the world. However, there is limited reporting on the status of some caregivers, including Chinese caregivers of stroke inpatients. Limited information is available on evaluations using the World Health Organization Quality of Life Instrument (WHOQOL) and the effects of resilience and self-efficacy on WHOQOL score. Therefore, we conducted research to assess the role of resilience on the WHOQOL and to investigate the role of self-efficacy as a mediator between resilience and WHOQOL score among Chinese caregivers of stroke inpatients. This cross-sectional study to gather data from north-east and south-east China was conducted from June 2019 to October 2019. Over 380 caregivers of stroke inpatients at two general public hospitals were interviewed face-to-face. About 305 caregivers (80.26%) completed the questionnaire, which included the Ego Resilience Scale, the General Self-Efficacy Scale, and the brief version of the WHOQOL and asked about demographic characteristics. This study also examined factors associated with WHOQOL score and used linear regression analysis and structure equation modelling to construct direct and indirect models, respectively. After adjustment for demographic characteristics, both resilience and self-efficacy were positively associated with all WHOQOL domains. Structure equation modelling revealed that self-efficacy mediated the relationship between resilience and WHOQOL score among caregivers of stroke inpatients. Chinese caregivers of stroke inpatients exhibited good social health but poor physical, psychological, and environmental health. It is necessary for promoting resilience and improving WHOQOL score through the mediating effect of self-efficacy. These results suggest that interventions in health care focused on both enhancing resilience and providing self-efficacy training could effectively improve WHOQOL score.

Exercise in the management of postural orthostatic tachycardia syndrome

Postural Orthostatic Tachycardia Syndrome (POTS) is an autonomic dysfunction characterized by orthostatic symptoms including an increase in heart rate of at least 30 beats per minute (bpm) or reaching above 120 bpm soon after a postural change (Busmer, 2011). Symptoms include, but are not limited to, dizziness, nausea, palpitations, sweating, and fatigue. Twenty-five percent of those with POTS are unable to work (Busmer, 2013). One common pharmacologic treatment is beta-blockers (Lai et al 2009). There is little research into non-pharmacologic treatments, including exercise. The purpose of this case study was to determine if physical activity alleviates physical (heart rate) and psychological (depression and anxiety) symptoms of a patient with POTS. Following eight weeks of physical activity, the patient still met the diagnostic criteria of POTS. However, her quality of life improved based on the WHOQOL-100 AND HADS scores, and she reported being able to perform more tasks at home without feeling heart palpitations. The case study showed an improvement in quality of life for the participant with POTS, but minimal changes in heart rate response following standing post-intervention.

The National Radium-223 Dichloride Audit Group: Data from patients in United Kingdom oncology centers with metastatic castration-resistant prostate cancer treated with radium-223 dichloride.

59 Background: Clinicians in 20 UK oncology centres comprise the National Radium-223 Dichloride Audit group which is evaluating treatment patterns and outcomes in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) treated with Radium-223 dichloride (Xofigo). Methods: Pts first treated with Xofigo from September 2017 were included and demographics, treatment, clinical, biochemical and outcome data collected prospectively. Analysis was carried out using frequency tables, univariate and survival analysis. Results: We report the outcomes on the first 100 pts in 4 centres with good quality data. Median values of each characteristic including 25th and 75th percentiles are as follows: Age at diagnosis = 67 years (62-72), weight = 83.5kgs (73.6-92.8), Hb = 139g/L (118 – 136), WCC = 7.3X109/L (5.7 – 8.7), plt count = 252x109/L (208 – 290), ALP = 128U/L (96-263) and PSA = 42.1ug/L (21.5 – 125.7). A majority of pts had an ECOG PS of 0-1. The number of pts having Xofigo as 1st, 2nd, 3rd and 4th line treatment was 15, 64, 20 and 1 respectively. There was a statistically significant decline in median weight, Hb, WCC, plt count and ALP and a rise in PSA between cycle 1 and cycle 6. Thirty eight pts did not complete 6 cycles with 31 of these (82%) discontinuing due to disease progression. The prevalence of adverse events was 5% (20/100). Twenty nine pts had a skeletal event by 12 months. There was no change in the WHO analgesic score, QOL scores or ECOG PS between treatment 1 and 6. Thirty nine pts had subsequent lines of treatment with 31 of these having only 1 line of treatment. Median overall survival was 363 days (95% CI 312-426 days). Conclusions: The ongoing National Radium-223 Dichloride Audit records data from approximately 600 mCRPC pts treated across the UK in routine clinical NHS care. To our knowledge, it is the first prospective analysis of such pts and the largest in assessing treatment patterns, outcomes and quality of life data in addition to standard biochemical and clinical parameters. Further multivariate analysis will be presented and the implications of the licensing change of Xofigo will be illustrated in the final analysis.

Assessing the health-related quality of life in type2 diabetes patients treated with insulin and oral antidiabetic agents.

Assessing the quality of life (QOL) for patients with type2 diabetes is an essential part of diabetes management, especially for the evaluation of new antidiabetic treatments and glucose monitoring technologies. Accordingly, the aim of this study was to assess QOL according to treatment types. This cross-sectional study included 170 patients with type2 diabetes from the region of Melk in Lower Austria. Of the patients 61 used only oral antidiabetic agents (OAD) and 109 patients were treated with insulin (with or without OAD). The QOL was assessed in patients using sodium-glucose cotransporter 2 inhibitors (SGLT2 inhibitors). Among the 170 patients with type2 diabetes 95used SGLT2 inhibitors. The World Health Organization Quality of Life BREF (WHOQOL-BREF) assessment was used to assess QOL among these patients. The Mann-WhitneyU-test was utilized in this study and aP value <0.05 was considered statistically significant. Regarding the 170 participants, most were male (58.82%) and the mean glycated hemoglobin (HbA1c) level was 55.46 ± 12.30 mmol/mol (7.2%). The WHOQOL-BREF scores among type2 diabetes patients were relatively high, which reflect a good QOL and the mean physical, psychological, social and environmental domain scores were 64.53 ± 20.15, 71.29 ± 18.08, 70.10 ± 20.08, and 84.419 ± 11.22 SD, respectively. There were no statistically significant differences in WHOQOL scores of the domains between the insulin-treated group and OAD group and between the group treated with SGLT2 inhibitors and the group not treated with SGLT2 inhibitors. This study showed no QOL distinctions between treatment groups in patients with type2 diabetes; however, alarge cohort study is needed to examine these groups further.

AGE FRIENDLINESS OF COMMUNITIES CONTRIBUTES TO QUALITY OF LIFE

The World Health Organization (WHO) emphasized the importance of age-friendly communities in supporting quality of life for older adults. We aimed to determine the contribution of the age-friendliness of communities to quality of life in a sample of healthy older adults. We used data collected through a longitudinal study on drivers and ex-drivers. We used the World Health Organization Quality of Life instrument (WHOQOL-BREF; WHOQOL Group, 1998) to measure physical health, psychological health, social relationships, and environment. We used the Age-Friendly Survey (AFS; Menec & Nowicki, 2014) to measure 9 domains of participants’ perceptions of community age-friendliness. We estimated 4 multivariable linear regression models. The dependent variables were the 4 domains of the WHOQOL-BREF. Each model had AFS as the focal independent variable and participants’ age, gender, health status, and depression symptoms as control variables. Data from 171 participants were available; mean age was 83.2 years (SD=4.1), 61% were women. Most participants reported a good health status and few depression symptoms. The models explained between 18 and 27% of the variance in WHOQOL scores; community age-friendliness was a statistically significant variable in all models, accounting for 2-3% of the variance. The identification of factors that contribute to quality of life will serve as the foundation upon which policies and interventions to promote successful and healthy aging can be developed. Future work will require consideration of the specific aspects of communities that may affect quality of life the most and that have the most potential for modification.

Effect of laparoscopic cervical cerclage combined with comprehensive nursing intervention on the mood and quality of life of the patients with cervical incompetence

Objective To discuss the influence of laparoscopic cervix cerclage combined with comprehensive nursing intervention on patients' mood and quality of life in cervical incompetence. Methods A total of 33 cases of cervical dysfunction patients who underwent pre-pregnancy cyclization from August 2015 to September 2017 were selected as the research group. A total of 63 cases of cervical dysfunction patients who underwent cyclization during the second trimester of the same period were selected as the control group.The average operation time, the time of hospitalization, the emotional changes before and after treatment, and the quality of life score of the two groups of patients were compared. Results No infection was found in the research group after operation, while that in the control group was 14.28% (9/63), and the difference was statistically significant (P<0.05). The mean operation time and hospitalization time in the research group were shorter than those in the control group, and the differences were statistically significant(P<0.05). After intervention, the decrease degree of Self-rating Anxiety Sale (SAS) and Self-rating Depression Scale (SDS) and increase degree of WHOQOL score were better than those of the control group, and the differences were statistically significant(P<0.05). Conclusions Laparoscopic cervical cerclage can improve the success rate of operation for patients with cervical insufficiency, and combined with comprehensive nursing intervention, it can effectively relieve patients' mood and improve their quality of life. Key words: Laparoscope preconception cervical cerclage; Cervical incompetence; Comprehensive nursing intervention; Mood; Quality of life