This literature review summarizes wheelchair transportation safety, focusing on areas pertinent to designing automated vehicles (AVs) so they can accommodate people who remain seated in their wheelchairs for travel. In these situations, it is necessary to secure the wheelchair to the vehicle and provide occupant protection with a Wheelchair Tiedown and Occupant Restraint System (WTORS). For this population to use AVs, a WTORS must be crashworthy for use in smaller vehicles, able to be used independently, and adaptable for a wide range of wheelchair types. Currently available WTORS do not have these characteristics, but a universal docking interface geometry and prototype automatic seatbelt donning systems have been developed. In the absence of government regulations that address this situation, RESNA and ISO have developed voluntary industry standards to define design and performance criteria to achieve occupant protection levels for wheelchair-seated passengers that are similar to those provided by conventional vehicle seats.