Abstract PPP_Mansoura is a new software that can process multi-GNSS data work on MATLAB environment and linked with C# in the preprocessing stage. It gives highly accurate results and provides a results file for each epoch, and the users can choose the GNSS system they want to run with the primary systems (GPS or GLONASS) and all this with simple MATLAB Code. For testing the software, we processed the raw data (RINEX 3) from 17 MGEX stations for 24 h data during 1-week with a 30-s interval time and submitted it to the new software and PPPH software. The averaged positioning errors obtained from PPP_Mansoura and PPPH were 5.14 mm and 6.9 mm respectively, for the East direction, 11.6 mm and 14 mm for the North direction, and 14.56 mm and 20.4 mm respectively for the Up direction, the averaged convergence time obtained from PPP_Mansoura and PPPH were 35.3 min and 54.47 min, so the results show that PPP_Mansoura give results with high accuracy can be comparable with PPP standards results and PPP software results.