Background: A pandemic of Coronavirus 2019 (COVID-19)may endanger the mental well-being of health care workers. Objective: This is to stipulate some mental issues faced by health care workers at the time of COV-SARS. Patients and Method: A cross-sectional study was conducted upon 5745 participants from the Qalyubiya Governorate (7 centers). Online self-administered questionnaire (Fear of Coronavirus-19 Scale (7 Qs scale) and The Hospital Anxiety and Depression Scale (HADS) (14 items of two subscales: anxiety and depression)) was utilized. Propensity score matching was performed to minimize bias between health care workers (1740) and non-healthcare workers. Results: After performing propensity score matching, 1740 participants were included for comparison between health care workers and non-healthcare workers. Health care workers expressed more fear, anxiety, and depression scores. Increasing hours of watching media is a predictor of fear, anxiety, and depression among health care workers ((95%CI: 0.555-1.4, p<.001), (0.77-1.22, p<.001) and (0.45-0.85, p<.001) respectively) and ((1.44-2.2, p<.001), (0.94-1.49, p<.001) respectively) among non-healthcare workers. Conclusions: HCW showed mental disorders scores more than non-healthcare workers. Among health care workers, females, the age group from 26 to 30 years, and more than 4h of watching media about COVID-19 had significantly higher mental scores. Non-married health care workers showed a higher fear score. Among non-healthcare workers, married and low educated levels expressed lower scores. [ABSTRACT FROM AUTHOR] Copyright of Egyptian Journal of Hospital Medicine is the property of Egyptian Journal of Hospital Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)