In northeast Russia, the famous historic Kolyma Road spans two thousand kilometers across two federal subjects of the Russian Federation: the Sakha Republic (Yakutia) and Magadan Oblast. Thousands of people live along and in close proximity to the road, depending on it for communication, mobility, goods, and life support. As the major transportation infrastructure in the entire region, it should be reliable and stable for local communities’ well-being. One strategic approach to ensure its reliability is to acknowledge the role of Indigenous knowledge, which has been neglected despite being established long before the emergence of existing formal systems of communication. Based on data collected through fieldwork, personal observations, and conversations, this paper aims to demonstrate that Indigenous knowledge regarding ways of living, moving, and communicating along and on the road is the key to sustainability in the region. As a result, we claim that this realization should be manifested in designing and implementing communication and mobility systems based on the principles of diversity, equity, and inclusion. In the long term, it is necessary to develop a sustainable road management system for the Kolyma Road to ensure the security and well-being of local communities and for everyone visiting and working on the road.