Introduction: Prior research has shown weight cycling, the repetitive pattern of weight loss and regain, is associated with increased CVD risk. There is limited evidence on the association of history of weight cycling (HWC) with cardiovascular health (CVH) metrics from the AHA Life’s Simple 7 (LS7). Hypothesis: We hypothesized that HWC is associated with poorer CVH in women and that these associations may vary by menopausal status and/or pregnancy history. Methods: This was a cross-sectional analysis of 485 women enrolled in the AHA Go Red for Women Strategically Focused Research Network. HWC, defined as losing and gaining ≥ 10 lbs at least once (excluding pregnancy) was self-reported. Participants were given scores of 0 (poor), 1 (moderate) or 2 (high) for each AHA LS7 metric (BMI, BP, total cholesterol, glucose, physical activity, diet and smoking). Metric scores were summed into a composite AHA LS7 CVH score: 0-8 (poor), 9-10 (moderate), 11-14 (high). Logistic regression was used to evaluate associations of HWC with AHA LS7 metrics and composite. Models were stratified by menopausal status and pregnancy history due to a statistically significant multiplicative interaction. Results: The majority of women (mean age 37±16y, BMI 26±6 kg/m 2 ), 73%, reported ≥ 1 HWC episode, and 26%, 34% and 40% of women had poor, moderate, and high CVH respectively. HWC was associated with lower odds of meeting the BMI metric or moderate or high AHA LS7 composite score, but not with other CVH metrics ( Table ). In stratified analyses, HWC was associated with lower odds of having a high AHA LS7 score in both pre- and post-menopausal women, but only in women who had never been pregnant. Conclusion: HWC was associated with lower odds of meeting the BMI metric and poorer CVH as assessed by AHA LS7 composite score. Associations were stronger in women with no pregnancy history. These findings suggest that in addition to having a healthy weight, maintaining a consistent body weight may be important for achieving ideal CVH, but they warrant prospective confirmation.