Abstract
Treatments that improve key biomarkers related to T2DM management are desirable, especially in LA, where patients are responsible for medication choices. CANA, an SGLT2 inhibitor, lowers glucose and BP in people with T2DM, along with the recognizable benefit of WL, which may reinforce performance of self-care behaviors. This analysis assessed the impact of WL on HRQoL in people with T2DM from LA. Post hoc pooled data from LA subjects in 4 CANA trials (vs placebo, sitagliptin, or glimepiride) on metformin ± sulfonylurea were used. Satisfaction with weight (SW) and physical health (SP) measured by the Current Health Satisfaction Questionnaire, burden of weight on HRQoL measured by the Impact of Weight on Quality of Life–Lite, and physical and mental function measured by SF-36 were analyzed. Patients were classified based on weight loss (L) or gain (G) patterns from baseline to Week 26 and Week 26 to Week 52 (ie, LL, LG, GL, GG). Logistic regression was used to determine the relationship between baseline characteristics and weight change and HRQoL at 52 weeks. Compared with subjects from the rest of the world (n=2,030), LA subjects (N=449; CANA, n=291; placebo/active comparators, n=158) had lower BMI (30.4 vs 31.6 kg/m2), higher SW (33.0% vs 17.4%), and higher SP (27.9 vs 24.7) at baseline (all P<0.001). At Week 52, 70% of LA subjects lost weight; of these, more received CANA (100/300 mg; 79%) vs placebo/active comparators (21%). Lower baseline HRQoL was associated with a significantly greater likelihood of improvement in most measures of HRQoL at Week 52 (P<0.001). Subjects who experienced the LL pattern were more likely to have improved SW compared with those who had a GG pattern (P=0.009). WL produces meaningful HRQoL improvements for people with T2DM in LA, which may lead to increased performance of healthy behaviors.
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