Weight Curves Research Articles

Percentile curves on growth among breastfed 1-4 year olds in 8 urban areas

Objective: To construct the growth percentile curves of weight-, length/height-, head circumference and BMI for 1 to 4 year-olds who had been breastfed in urban areas. Methods: Data was from the longitudinal study on 1 025 breastfed children aged 1 to 4 years, in 8 urban areas during 2008-2012. MLwiN2.25 was selected to construct the multi-level models of weight-for-age,length for-age, head circumference-for-age and BMI-for-age. The models included many growth relevant factors including gender, age, family and social demographic characteristics, perinatal factors, parent biological characteristics, dietary patterns and diseases of childen. Based on these models, predicted values (P(3), P(15), P(50), P(85), P(97)) were estimated to fit the percentiles reference curves. Results: The percentiles reference curves of weight-, length/height, head circumferenceand BMI-for-age for the 1-4 year-olds who had been breastfed in the urban areas were developed. Differences of all the indicators between boys and girls were statistically significant (P<0.001). Weight, length/height, head circumference and BMI were higher in boys than those in girls, with an average differences as 0.56-0.76 kg, 0.89-1.12 cm, 0.64-0.91 cm and 0.31-0.52 kg/m(2). Conclusion: The percentiles reference curves on growth, constructed by the longitudinal observational data and scientific method, were important in reflecting the development of breastfed children in urban areas.

Fetal size monitoring and birth-weight prediction: a new population-based approach.

To develop a complete, population-based system for ultrasound-based fetal size monitoring and birth-weight prediction for use in the second and third trimesters of pregnancy. Using 31 516 ultrasound examinations from a population-based Norwegian clinical database, we constructed fetal size charts for biparietal diameter, femur length and abdominal circumference from 24 to 42 weeks' gestation. A reference curve of median birth weight for gestational age was estimated using 45 037 birth weights. We determined how individual deviations from the expected ultrasound measures predicted individual percentage deviations from expected birth weight. The predictive quality was assessed by explained variance of birth weight and receiver-operating characteristics curves for prediction of small-for-gestational age. A curve for intrauterine estimated fetal weight was constructed. Charts were smoothed using the gamlss non-linear regression method. The population-based approach, using bias-free ultrasound gestational age, produces stable estimates of size-for-age and weight-for-age curves in the range 24-42 weeks' gestation. There is a close correspondence between percentage deviations and percentiles of birth weight by gestational age, making it easy to convert between the two. The variance of birth weight that can be 'explained' by ultrasound increases from 8% at 20 weeks up to 67% around term. Intrauterine estimated fetal weight is 0-106 g higher than median birth weight in the preterm period. The new population-based birth-weight prediction model provides a simple summary measure, the 'percentage birth-weight deviation', to be used for fetal size monitoring throughout the third trimester. Predictive quality of the model can be measured directly from the population data. The model computes both median observed birth weight and intrauterine estimated fetal weight. Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.

L’effet de la méthylphénidate sur l’appétit et le poids

ObjectivesTo better delineate in the medical literature the effect of methylphenidate on weight and appetite. MethodsA search on PubMed was carried out for articles published with no restrictions on language or year of publication using the terms: “methylphenidate”; “weight”; “appetite”. ResultsMethylphenidate increases dopamine and noradrenaline in synapses because of its blockage of the transporters of these monoamines in the frontal cortex and insular lobe. The intracerebral activity of methylphenidate is incriminated in the dysregulation of appetite due to its probable effect stimulating the disgust sensation generated after the activation of the insular lobe by the drug. The anorexigenic effect of methylphenidate has been demonstrated in preclinical studies although the dosage and the administration routes differ in animals from those used for human beings. In clinical studies, methylphenidate decreases the weight of children and adolescents during the first 3 to 6 months after its initiation due to the appetite reduction effect that it generates with a tendency of weight curves to rejoin the curves of subjects who did not receive the treatment a few years after its initiation. ConclusionThe anorexigenic effect of methylphenidate does not persist over the long-term in children and adolescents who receive it.

Biological value of shrimp protein hydrolysate by-product produced by autolysis

The current study aimed to determine the biological value of shrimp by-product protein hydrolysate (SPH) produced by enzymatic autolysis. The biological experiment was carried out using Wistar strain, male rats, recently weaned, divided into three groups of eight. The groups received protein-free, casein (control) and SPH (experimental) diets for 28 days. Body weight, food and water consumption, urine volume, protein efficiency ratio (PER), food efficiency ratio (FER), net protein ration (NPR), relative net protein ratio (RNPR), in vivo protein digestibility, apparent digestibility and biochemical parameters were analyzed. No significant differences were observed among groups regarding weight curves and weekly weight gain, except for during the fourth week, when the SPH group presented greater weight gain. The casein group presented statistically higher levels of consumption in the first weeks in comparison to the SPH group. Regarding PER, FER, NPR and RNPR, animals on the SPH diet obtained statistically higher values than those on the casein diet. SPH proved to be of high biological value, as the rats on this diet presented greater biological responses than those in the casein-controlled group. Thus, SPH should be further studied with respect to its potential for use as a supplement in the human diet.

Population-based birth weight reference percentiles for Chinese twins

Background: Birth weight percentiles by gestational age are important for assessing prenatal growth and predicting postnatal outcomes of newborns. Several countries have developed nation-specific birth weight references for twins, but China still lacks such references.Methods and results: Birth weight data for twins born between October 2006 and September 2015 were abstracted from the China National Population-based Birth Defects Surveillance System. A total of 54,786 live twin births aged ≥28 weeks of gestation without birth defects were included in the analysis. The LMS method was adopted to generate gestational age-specific birth weight percentiles and curves for male and female twins separately. Significant differences were observed between the current reference and other references developed for Chinese or non-Chinese twins. The neonatal mortality rate in this cohort was 12.3‰, and much higher rates at very early gestation weeks were identified in small-for-gestational-age twins grouped by the newly developed reference cutoffs.Conclusions: The established birth weight centiles represent the first birth weight norm for contemporary Chinese twins and can be a useful tool to assess growth of twins in clinical and research settings.Key MessagesThere have been no population-based birth weight percentiles for Chinese twins prior to this study. The established birth weight centiles for female and male twins are markedly lower than those for Chinese singletons. Twin-specific curves should be used for determining inappropriate for gestational age in twins rather than using existing singleton reference.The birth weight percentiles for twins differed significantly from those for non-Chinese twins. In addition to ethnic influences, the observed differences could be ascribed to variations in prenatal care, fetal or maternal nutrition status or other environmental factors.Neonatal mortality rates varied considerably among twins grouped by the newly developed reference percentiles. Small-for-gestational-age twins had much higher mortality than did appropriate-for-gestational-age twins, highlighting the need to reduce postnatal mortality by improving perinatal health care for twins.

Effect of exogenous gibberellin on endogenous hormone content and development of 'Black Corinth' grapes

The relationship between growth and development of potassium gibberellate (KGA3 )-treated 'Black Corinth' berries and changes in the level of hormones was studied from anthesis to maturity. Growth rate curves for fresh weight and volume had peaks corresponding to stages I and III. The curve for dry weight showed only one large pea k that occurred in stage III. Associated with the first period of rapid growth (stage I) was a rapid increase in concentration of hormone. Application of KGA3 increased auxin activity within 3 hours after treatment, and berries from KGA3-treated vines maintained a higher level of auxin activity during stage I and stage II than did berries from untreated vines. Hormone content decreased during the period of retarded growth (stage II), and continued at a low level until harvest.

EVALUATION OF PHYSICAL DEVELOPMENT OF NEWBORNS AND CHILDREN OF EARLY AGE

The aim of this review is to present a visual study of the physical development of newborns and children of early age using percentile diagrams, recommended by the experts from the World Health Organization, and the evaluation of anthropometric indices in preterm infants. Graphical curves of body weight, height for age, body mass in accordance with the growth of boys and girls of a young age may be used for the work of pediatricians; graphical curves of weight, length, head circumference and weight-height ratio in preterm infants – neonatologians.

ASSESSING PHYSICAL DEVELOPMENT OF CHILDREN WITH PERCENTILE DIAGRAMS

The results of the analysis of methods assessing anthropometric measures in children are presented. A method for visual examination of physical development using author's percentile diagrams for height, body weight, and the harmony of development of children of different age groups is offered. The method can be quickly performed, it is recommended for mass screening examination of children under outpatient treatment. To monitor the health of a specific child, a monitoring assessment of physical development is possible. The analysis of Z-score is of great clinical importance when determining anthropometric measures below the 3rd percentile, for the assessment of premature infants with congenital malformations and other diseases, in the presence of obesity. Graphical curves of body weight, height to age, body weight according to the height of boys and girls can be used by pediatricians.

IS THERE REALLY A NEED TO CREATE «REGIONAL PERCENTILE CURVES» OF WEIGHT-HEIGHT PARAMETERS? (COMMENT TO THE ARTICLE BY RITA R. KILDIYAROVA «ASSESSING PHYSICAL DEVELOPMENT OF CHILDREN WITH PERCENTILE DIAGRAMS»)

Height, body weight and body mass index are important parameters of health and are widely used in clinical practice, for assessing health of children, and for population studies. Amid the general globalization, the main trend of the present time is joining efforts of various countries for prevention and treatment of diseases in children. The work of the World Health Organization (WHO) on creation of international standards of anthropometric measures and parameters of children's development is based upon this trend. A key point of the WHO standards is their creation based on a survey of a large cohort of children (from 5 countries of 6 continents) who were in optimal conditions: who were breast-fed and received the up-to-date level of care and quality of the provided medical care. This actually allowed to eliminate the main exogenous factors that affect such parameters and to make them, in fact, the reference ones. The application of a unified approach using the WHO standards allows to carry out multicenter studies involving different countries as well as to compare the data obtained in different regions. Studies have shown that the WHO standards for physical development are applicable in different regions of the world. In this regard, the creation of «regional» reference curves for height and body weight of children that are different from the generally accepted standards is currently inappropriate, but it is really relevant to use the WHO standards.

Automated high-temperature liquid level measurement system using a dynamic tube pressure technique

Abstract An in-house manufactured liquid level measurement system based on dynamic tube pressure measurements was established for high-temperature corrosive molten salts. The accuracy and precision of the present technique depend on the furnace temperature, initial base tube pressure, and tube speed. Whereas the initial base tube pressure did not influence the performance of the measurements significantly, a set value of the critical pressure level for the detection of the liquid surface was an important factor, especially in case of the higher temperature experiments. Within a temperature range of 773–1073 K using KNO 3 , our technique could obtain a measurement error of less than ca. 0.05 mm in precision. The tube speed increased from 0.25 mm s −1 to 2.00 mm s −1 , resulting in a % departure of only 1.1%, 1.3%, and 1.9% at 773 K, 973 K, and 1073 K, respectively. The measurement of travel distance instead of measuring the liquid level is useful in terms of the calibration-free process monitoring. The gravimetric calibration method was also used to determine the total mass of the liquid, where the weight versus travel distance calibration curves showed an excellent linearity with R 2 = 0.9999 under all temperature conditions.

Weight Trajectory over 20 Years and Likelihood of Mild Cognitive Impairment or Dementia Among Older Women.

The association between weight change and cognition is controversial. We examined the association between 20-year weight change and cognitive function in late life. Cohort study. Study of Osteoporotic Fractures (SOF). One thousand two hundred eighty-nine older, community-dwelling women (mean baseline age 68 (65-81) and 88 (82-102) at cognitive testing). Study of Osteoporotic Fractures participants had body weight measured repeatedly over 20 years (mean 8 weights). Adjudicated cognitive status was classified as normal (n = 775) or mild cognitive impairment (MCI)/dementia (n = 514) at Year 20. Logistic models were used to evaluate whether absolute weight change, rate of weight loss per year, presence of abrupt, unrecovered weight loss, and weight variability were associated with MCI or dementia. Women with greater rate of weight loss over 20 years had increased chance of developing MCI or dementia. In age/education/clinic-adjusted "base" models, each 0.5 kg/yr decrease resulted in 30% increased odds of MCI/dementia (OR = 1.30 [95% CI: 1.14, 1.49]). After adjustment for age, education, clinic, depression, and walking speed, there was 17% (OR = 1.17 [95% CI: 1.02, 1.35]) increased odds of MCI/dementia for each 0.5 kg/yr decrease in weight. In base models, variability in weight was significant. Each 1% average deviation from each woman's predicted weight curve was associated with 11% increased odds of MCI/dementia (OR = 1.11 [95% CI: 1.04, 1.18]). The estimate was attenuated after full adjustment (OR = 1.06 [95% CI: 0.99, 1.14]). The presence of an abrupt weight decline was not associated with MCI/dementia. Rate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years, suggesting that nutritional status, social-environmental factors, and/or adipose tissue function and structure may affect cognitive function with aging.

Analyzing Growth Curves of Turkeys Reared in Different Breeding Systems (Intensive and Free-Range) with some Nonlinear Models

The objective of this study was to identify the growth curve of live weight of turkeys reared in different systems (intensive and free- range) with the best mathematical model. To achieve this goal, the live weight of male and female turkeys (Large White) reared for 0-18 weeks were used. Logistic, Gompertz, Von Bertalanffy, and Gauss were used to determine the best model for the turkeys. In comparison of the models, values of Coefficient of Determination (R2), Mean Squares of Error (MSE) and Model Efficiency (ME) were used. In Von Bertalanffy model, the coefficient of determinations for males and females were found as 0.9974 and 0.99915 in intensive system and 0.9794 and 0.9804 in Free-Range system, respectively. As a result of this study, because the highest R2 and the lowest MSE were observed in Von Bertalanffy model, it was the best among the models to identify growth curve of the turkeys.

Reference curves of birth weight, length, and head circumference for gestational ages in Yogyakarta, Indonesia

BackgroundThe birth weight reference curve to estimate the newborns at risk in need of assessment and monitoring has been established. The previous reference curves from Indonesia, approximately 8 years ago, were based on the data collected from teaching hospitals only with limited gestational ages. The aims of the study were to update the reference curves for birth weight, supine length and head circumference for Indonesia, and to compare birth weight curves of boys and girls, first child and later children, and the ones in the previous studies.MethodsData were extracted from the Maternal-Perinatal database between 1998–2007. Only live singletons with recorded gestational ages of 26 to 42 weeks and the exact time of admission to the neonatal facilities delivered or referred within 24 h of age to Sardjito Hospital, five district hospitals and five health centers in Yogyakarta Special Territory were included. Newborns with severely ill conditions, congenital anomaly and chromosomal abnormality were excluded. Smoothening of the curves was accomplished using a third-order polynomial equation.ResultsOur study included 54,599 singleton live births. Growth curves were constructed for boys (53.3%) and girls (46.7%) for birth weight, supine length, and head circumference. At term, mean birth weight for each gestational age of boys was significantly higher than that of girls. While mean birth weight for each gestational age of first-born-children, on the other hand was significantly lower than that of later-born-children. The mean birth weight was lower than that of Lubchenco’s study. Compared with the previous Indonesian study by Alisyahbana, no differences were observed for the aterm infants, but lower mean birth weight was observed in preterm infants.ConclusionsUpdated neonatal reference curves for birth weight, supine length and head circumference are important to classify high risk newborns in specific area and to identify newborns requiring attention.

Vascular repair and regeneration are improved with reduced expression of the insulin-like growth factor-1 receptor in whole body insulin resistance

Rationale Insulin resistance increases the risk of cardiovascular disease. Previous work from our department using mice haploinsufficient for either the IR (IRKO), IGF-1R (IGF-1RKO) or both receptors (DKO) showed that endothelial dysfunction caused by insulin resistance could be rescued by reducing IGF-1R expression. Whether there might also be an improvement in vascular repair and regeneration in this setting is unclear. Methodology Weight curves and glucose and insulin tolerance tests were used for metabolic assessment. Denuding femoral artery injury was performed with angioplasty guidewires; repair was quantified in Evans Blue-perfused vessels at day 4. Hindlimb ischemia experiments involved left femoral artery ligation and excision, with contralateral sham surgery. Recovery was assessed weekly by laser Doppler. Flow cytometry was used to count circulating progenitor cells (CPCs) expressing Sca1/KDR. Data are expressed as mean (standard error) and compared using t-tests; * denotes p Results Body weight was significantly lower in DKO than IRKO [area under curve (arbitrary units) 116 (2.1) vs 123 (2.4)* n = 15]. Glucose and insulin tolerance tests were similar in DKO and IRKO mice. The DKO group had superior re-endothelialisation after denuding femoral artery wire injury compared with IRKO [55 (4)% vs 46 (6)%* n = 8–14]. Recovery after induction of hindlimb ischemia was greatest in the DKO group [area under curve limb perfusion ratio (arbitrary units) 2.2 (0.11) vs 1.3 (0.08)* n = 12–19]. No difference was noted in CPC populations. Conclusion Reducing IGF-1R expression improves vascular repair and regeneration in the context of whole-body insulin resistance. Further work will aim to elucidate the possible mechanisms for these observations.

Standard curves of placental weight and fetal/placental weight ratio in Japanese population: difference according to the delivery mode, fetal sex, or maternal parity

ObjectivesPlacental weight (PW) and fetal/placental weight ratio (F/P) have been considered to be useful parameters for understanding the pathophysiology of fetal growth. However, there have been no standard data on PW and F/P in Asian populations. This study was conducted to establish nomograms of PW and F/P in the Japanese population and to clarify characteristics of PW and F/P in this population. Study designIncluded in the study were 79,590 Japanese cases: 58,871 vaginal and 20,719 cesarean deliveries at obstetrical facilities (2001–2002) and registered to the Japan Society of Obstetrics and Gynecology Database. Multiple pregnancies, stillbirths, and fetal anomalies were excluded. Nomograms of PW and F/P were created by spline methods in groups categorized by fetal sex (male or female) and maternal parity (primipara or multipara). ResultsStandard curves of PW and F/P were established, which indicated that PW and F/P were lower in cesarean deliveries than vaginal deliveries, especially during preterm period. PW differed depending on fetal sex and maternal parity. F/P differed according to fetal sex. ConclusionWe for the first time established standard curves of PW and F/P in the Japanese population with statistically sufficient data, which showed that PW and F/P were lower in cesarean deliveries. PW and F/P were also affected by fetal sex. These data might be useful to understand the pathophysiology between the fetus and placenta in utero.

Growth charts for individuals with rhizomelic chondrodysplasia punctata.

Rhizomelic chondrodysplasia punctata (RCDP) is a class of peroxisomal disorders characterized by defective plasmalogen biosynthesis. There are multiple recognized types of RCDP, all of which have autosomal recessive inheritance, and their associated genes are known: RCDP type 1 with PEX7, RCDP type 2 with GNPAT, RCDP type 3 with AGPS, RCDP type 4 with FAR1, and RCDP type 5 with PEX5. Among other medical/developmental issues, plasmalogen deficiency has a direct effect on bone growth and results in postnatal growth failure, the severity of which corresponds to the degree of plasmalogen deficiency. In order to document growth in patients with RCDP, we present detailed growth curves for length, weight, and head circumference derived from retrospective data from 23 individuals with RCDP types 1 and 2 confirmed by molecular and/or biochemical studies. We stratified growth curves by age as well as by plasmalogen level, with those with higher plasmalogens grouped as "non-classic." The growth charts presented here provide guidance to families and physician caretakers on the natural course of growth in individuals with RCDP during infancy into early childhood, and thus will have particular utility in setting expectations and guiding optimal feeding interventions in this population.© 2016 Wiley Periodicals, Inc.

Knock-In of the Recurrent R368X Mutation of PRKAR1A that Represses cAMP-Dependent Protein Kinase A Activation: A Model of Type 1 Acrodysostosis.

In humans, activating mutations in the PRKAR1A gene cause acrodysostosis 1 (ACRDYS1). These mutations result in a reduction in PKA activation caused by an impaired ability of cAMP to dissociate mutant PRKAR1A from catalytic PKA subunits. Two striking features of this rare developmental disease are renal resistance to PTH and chondrodysplasia resulting from the constitutive inhibition of PTHR1/Gsa/AC/cAMP/PKA signaling. We developed a knock-in of the recurrent ACRDYS1 R368X PRKAR1A mutation in the mouse. No litters were obtained from [R368X]/[+] females (thus no homozygous [R368X]/[R368X] mice). In [R368X]/[+] mice, Western blot analysis confirmed mutant allele heterozygous expression. Growth retardation, peripheral acrodysostosis (including brachydactyly affecting all digits), and facial dysostosis were shown in [R368X]/[+] mice by weight curves and skeletal measurements (μCT scan) as a function of time. [R368X]/[+] male and female mice were similarly affected. Unexpected, however, whole-mount skeletal preparations revealed a striking delay in mineralization in newborn mutant mice, accompanied by a decrease in the height of terminal hypertrophic chondrocyte layer, an increase in the height of columnar proliferative prehypertrophic chondrocyte layer, and changes in the number and spatial arrangement of proliferating cell nuclear antigen (PCNA)-positive chondrocytes. Plasma PTH and basal urinary cAMP were significantly higher in [R368X]/[+] compared to WT mice. PTH injection increased urinary cAMP similarly in [R368X]/[+] and WT mice. PRKACA expression was regulated in a tissue (kidney not bone and liver) manner. This model, the first describing the germline expression of a PRKAR1A mutation causing dominant repression of cAMP-dependent PKA, reproduced the main features of ACRDYS1 in humans. It should help decipher the specificity of the cAMP/PKA signaling pathway, crucial for numerous stimuli. In addition, our results indicate that PRKAR1A, by tempering intracellular cAMP levels, is a molecular switch at the crossroads of signaling pathways regulating chondrocyte proliferation and differentiation. © 2016 American Society for Bone and Mineral Research.

Sorption and Degradation Behaviour of Epoxy Composites Reinforced with Amine-Coated Polyester Triangular Bars in Acid Environment

Sorption and degradation characteristics of epoxy composites reinforced with amine-coated polyester triangular bars in acid environment were studied. The following aspects of amine-coated triangular bars were varied during preparation of epoxy composites: orientation (flat or pointed), alignment (parallel or staggered), spacing (1 or 5 mm), and size (5 or 7 mm). Composites were tested using a one-side acid exposure test in 5 wt% hydrochloric (HCl) acid solution at 40°C for 308 h. Weight change curves of composites with pointed orientation show continuous sorption of acid solution with square root of time, while composites with flat orientation display an initial increase in weight followed by continuous weight loss. This can be attributed to the large interfacial area of triangular bars exposed to diffusing acid in flat orientation. Since the bars are amine-coated, the acid preferentially diffuses in the interfacial region, resulting to early degradation of composite. The following parameters were measured from the weight curves for data analysis: initial sorption rate (% - h-0.5), maximum weight change during sorption (%), and weight loss due to degradation (%). Analysis of variance (ANOVA) shows maximum weight change and weight loss due to degradation of epoxy composites are significantly affected by orientation and spacing.

Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth

Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. FGR pregnancies are often associated with histological evidence of placental vascular thrombosis. The proteoglycans are important components and regulators of vascular homeostasis. Previous studies from our laboratory highlighted mRNA and protein expression differences in placental proteoglycan decorin (DCN), within a clinically well-characterised cohort of third-trimester idiopathic FGR compared with gestation-matched uncomplicated control pregnancies. We also showed that decorin contributes to abnormal angiogenesis and increased thrombin generation in vitro. These observations suggest that DCN gene expression may contribute to the etiology of FGR. Small for gestational age (SGA) is frequently used as a proxy for FGR and is defined as a birth weight below the 10th percentile of a birth weight curve. We therefore made use of a unique resource of first trimester tissues obtained via chorionic villus sampling during the first trimester to investigate the temporal relationship between altered DCN expression and any subsequent development of SGA. We hypothesized that placental DCN expression is decreased early in gestation in SGA pregnancies. Surplus chorionic villus specimens from 15 women subsequently diagnosed with FGR and 50 from women with uncomplicated pregnancies were collected. DCN mRNA and DCN protein were determined using real-time PCR and immunoblotting, respectively. Both DCN mRNA and protein were significantly decreased in placentae from first-trimester SGA-pregnancies compared with controls (p < 0.05). This is the first study to report a temporal relationship between altered placental DCN expression and subsequent development of SGA.

Physical growth curves of indigenous Xavante children in Central Brazil: results from a longitudinal study (2009–2012)

Background: The nutritional profile of Indigenous children in Brazil is comparable to those observed in some of the least developed regions of the world.Aim: Weight and height growth curves were characterised based on longitudinal data from a local Indigenous population experiencing the double burden of child under-nutrition and adult obesity.Subjects and methods: Anthropometric data were collected in six waves from 2009–2011 for children <10 in two proximate Xavante villages in Central Brazil. Prevalence rates for stunting, wasting and thinness were calculated using WHO references. Weight and height data were adjusted for generalised additive mixed models to generate growth curves.Results: Prevalence rates of stunting and wasting were high, but cases of thinness and excess weight were negligible. Weight and height began close to WHO medians, but fell substantially before 12 months. Boys but not girls were able to catch-up in weight before age 10. From 3–10 years, height for both sexes remained between −2 and 0 z-scores.Conclusion: Impaired Xavante growth before 1 year followed by inconsistent recovery before 10 years reflects health and wellbeing disparities with regard to the Brazilian national population and a complex epidemiology of growth involving rapid nutritional change.