A single electrode based triboelectric nanogenerator (TENG) utilising a human skin as an active triboelectric layer for self-powered wearable devices and electronics applications is presented. The proposed flexible TENG was fabricated by sandwiching a conductive elastomer and fabric films with polydimethylsiloxane through a simple and cost effective process. The fabricated device exhibited an average open-circuit voltage and short-circuit current of 107.2 V/0.32 μA/cm2 and 132 V/0.5 μA/cm2, respectively. With the integration of rectifier circuit, 4.7 μF capacitor was charged using the proposed TENG up to 6.6 V.