Neutrino experiments, in the next years, aim to determine with precision all the six parameters of the three-neutrino standard paradigm. The complete success of the experimental program is, nevertheless, attached to the non-existence (or at least smallness) of Non-Standard Interactions (NSI). In this work, anticipating the data taken from long-baseline neutrino experiments, we map all the weakly coupled theories that could induce sizable NSI, with the potential to be determined in these experiments, in particular DUNE. Once present constraints from other experiments are taken into account, in particular charged-lepton flavor violation, we find that only models containing leptoquarks (scalar or vector) and/or neutral isosinglet vector bosons are viable. We provide the explicit matching formulas connecting weakly coupled models and NSI, both in propagation and production. Departing from the weakly coupled completion with masses at TeV scale, we also provide a global fit on all NSI for DUNE, finding that NSI smaller than 10−2 cannot be probed even in the best-case scenario.