Weak Function Research Articles

Effect of electric field intensity on droplet fragmentation in oil-in-water-in-oil (O/W/O) emulsions: A molecular dynamics study

Oil-in-water-in-oil (O/W/O) emulsions commonly exist in crude oil treatment, food processing, pharmaceuticals, and cosmetics; however, few related studies have been conducted. To reveal the fragmentation mechanism of droplets in O/W/O emulsions, the behavior of complex droplets under different electric field intensities was investigated using a molecular dynamics method. It was found that the deformation of the intermediate phase (water) and the internal phase (hexane) increased dramatically with the electric field intensity, and the two phases separated when E ≥ 1.1 V∙nm−1, indicating that the complex droplets had been simplified into two simple liquids. Observation of the droplet trajectory shows that the deformation of the internal phase was smaller than that of the intermediate phase, and the internal oil droplet moved toward the high electric potential position. Furthermore, we elaborated the interactions between different phases at the molecular level by means of weak interactions and radial distribution function analysis, and their magnitudes were as follows: Cl− - Na+ > Na+ - Water > Water - Hexane. The electric fragmentation mechanism of the complex droplets was investigated, which provides theoretical guidance for the treatment of O/W/O emulsions by electrodehydration.

Classification of Urban Agricultural Functional Regions and Their Carbon Effects at the County Level in the Pearl River Delta, China

Exploring the transformation process of urban agricultural functions and its interaction with carbon effects based on regional differences is of great positive significance for achieving a low-carbon sustainable development of agriculture in metropolitan areas. By using the index system method, self-organizing feature maps (SOFM) network modeling, and Granger causality analysis, we divided the agricultural regional types of the Pearl River Delta (PRD) based on the spatio-temporal changes in urban agricultural functions and carbon effects at the county level in the PRD from 2002 to 2020, and analyzed the carbon effects generated by the agricultural functions according to the differences between the three agricultural regional types. The results show the following: (1) The changes in the basic functions of agriculture, the intermediate functions of agriculture, and the advanced functions of agriculture were different from the perspectives of both time and space. (2) The carbon effects produced by the areas with weak agricultural functions, the areas with medium agricultural functions, and the areas with strong agricultural functions were different. (3) The evolution of agricultural production types aggravated the grain risk in the PRD, and urban agriculture has potential in improving food security. (4) Based on the regional types of agricultural functions and considering the constraints of land and water, strategic suggestions such as integrating natural resources, improving utilization efficiency, upgrading technical facilities, and avoiding production pollution are put forward. (5) The green and low-carbon transformation of urban agriculture has its boundaries. The positive effects of the factors, namely the innovation of agricultural production methods, the change in agricultural organization modes, the impact of market orientation, and the transfer of the agricultural labor force, is limited. The findings of this paper provide valuable and meaningful insights for academia, policy makers, producers, and ultimately for the local population in general, driving the development of urban agriculture in a low-carbon and sustainable direction.

Effect of Blood Flow Restriction in Low-Intensity Resistance Training of the Quadriceps Femoris Muscle on Joint Position Sense and Threshold to Detect Passive Motion in Patients with Knee Osteoarthritis

Backgrounds: The functional ability of knee OA (KOA) patients is mainly affected by muscle weakness and poor proprioception function. Quadriceps femoris strengthening exercises can improve proprioceptive function in patients with KOA, whereas low-intensity resistance exercises with Blood Flow Restriction have been shown to produce hypertrophy and increase muscle strength equivalent to high-intensity resistance exercises. However, prescriptions for exercise with BFR are still very diverse, and only a few studies show the effects of BFR training on proprioceptive function in patients with KOA. This study aims to determine the impact of BFR in LI-RT of the quadriceps femoris muscle on joint position sense and threshold to detect passive motion in patients with KOA. Methods: This randomized control trial study designed a clinical experiment with a before and after test. The research enrolled 28 people with KOA grades 2 and 3. The JPS and TTDPM, which reflect proprioceptive function, were measured before and after 6 weeks of exercise. This study's statistical analysis utilized the Monte Carlo test, independent t-test, and paired t-test. The effect size was noticed using Cohen's-d calculation to investigate the statistical influence of alterations further. The significance level was less than 0.05. Results: The mean age of the control group was 61.43 ± 5.70 years old, and the treatment group was 57.71 ± 5.25 years old. There were significant improvements in JPS and TTDPM results before and after training in each group (p < 0,05). There was no significant difference in JPS and TTDPM results between the two groups on the post-test on delta values (p> 0,05). Conclusions: The addition of BFR in LI-RT for 6 weeks did not affect JPS and TTDPM in patients with KOA.

The scale factor effect on Young’s modulus of steel specimens determined by tensile tests

The modulus elasticity (or Young’s modulus) is considered to be a rather stable physical and mechanical characteristic of metallic materials being a weak function of the chemical composition and structure. However, the temperature and anisotropy can be referred as the main factors affecting the Young modulus. Scanty data on the scale factor effect on Young’s modulus are sometime even contradictory. We present the results of studying the impact of the scale factor on Young’s modulus of steel 45 determined by the tension of cylindrical tensile specimens with different initial diameters on an Instron 8801 machine with a movable traverse speed of 0.1 mm/min at room temperature. An extensometer and a digital image correlation (DIC) method were used to measure elastic deformations. Both methods showed fairly close results during tensile testing of specimens with equal diameters. DIC method made it possible to measure elastic deformations on small-size specimens on which it was impossible to fix the extensometer. A decrease in the Young modulus with an increase in the specimen diameter has been revealed. Graphical dependences of the Young modulus on the specimen diameter and cross-sectional area have been obtained. Possible reasons for the decrease in the Young modulus under the influence of the scale factor have been indicated. A decrease in the specific surface area and specific surface energy, an increase in the deformable volume, and a decrease in the strain rate at a constant movable traverse speed are among the main reasons. The decrease in Young’s modulus under the influence of the scale factor must be taken into account in strength calculations and in assessing the residual life of large-scale parts and structures with relatively large cross sections and wall thicknesses.

The altered composition of gut microbiota and biochemical features as well as dietary patterns in a southern Chinese population with recurrent renal calcium oxalate stones.

The correlation among gut microbiota, biochemical features, and dietary patterns in recurrent stone formers has been inadequately investigated in the Chinese population. Forty-two patients with calcium oxalate stones (CaOxS group), including 34 recurrent stone formers (RS group), and 40 nonstone healthy subjects (NS group) from Changshu Hospital Affiliated with Soochow University, were prospectively recruited. Food frequency questionnaires were completed by participants, fasting vein blood was extracted, 24-h urine was collected for biochemical detection, and fecal samples were gathered for 16S ribosomal RNA (rRNA) gene sequencing. BMI; serum levels of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), magnesium, and creatinine; and urine levels of magnesium in stone formers were significantly different from those of controls, and RS patients showed significantly low serum phosphate and high urine phosphate levels. Celery, bamboo shoots, and pickled food were the favored foods of local stone formers. Patients with recurrent stones had altered microbiota composition, with Escherichia, Fusobacterium, and Epulopiscium being the predominant pathogenic genera. The gut microbiota in RS patients had stronger functions in fatty acid and amino acid degradation but weaker functions in their biosynthesis. The pathogenic genera were positively correlated with BMI; serum levels of TGs and creatinine; urine levels of calcium, phosphate, and uric acid (UA); and celery, bamboo shoots, and pickled food intake. The abundance of Escherichia and Fusobacterium and the levels of serum magnesium and creatinine were the most relevant factors associated with stone recurrence and could be validated as biomarkers of recurrence. Our research provides a novel prevention strategy for the recurrence of renal calcium oxalate stones in the Han Chinese population of southern China.

Effects of Reservoir Boundary Conditions, Drainage Shape, and Well Location on Productivity of a Vertical Well

This paper gives a review of steady state and pseudosteady state productivity equations for an unfractured fully penetrating vertical well in a permeability anisotropic reservoir. This paper also studies the effects of drainage area, reservoir boundary conditions, drainage shape, and well location on productivity. The production performances of an unfractured vertical well in a circular reservoir, a sector fault reservoir and a rectangular reservoir are studied and compared. Mechanical skin factor is included in the productivity equations. This paper examines the steady state and pseudosteady state production performance of oil wells with constant flow rates in different drainage shapes, a library of productivity equations is introduced, several combinations of closed and/or constant pressure boundary conditions are considered at lateral reservoir boundaries. The equations introduced in this paper can be used to determine the economical feasibility of a drilling an unfractured fully penetrating vertical well. It is concluded that, drainage area and reservoir boundary conditions have significant effects on productivity of a well, and productivity is a weak function of drainage shape and well location.

Weak gluteus maximus and weak iliopsoas with normal gluteus maximus: Two complementary new signs to diagnose lower limb functional weakness.

The diagnosis of functional neurological disorder should be actively made based on the neurological signs. We described two new complementary signs to diagnose functional weakness of the lower limb, "weak gluteus maximus (weak GM)" and "weak Iliopsoas with normal gluteus maximus (weak iliopsoas with normal GM)," and tested their validity. The tests comprised Medical Research Council (MRC) examinations of the iliopsoas and GM in the supine position. We retrospectively enrolled patients with functional weakness (FW) or structural weakness (SW) who presented with weakness of either iliopsoas or GM, or both. Weak GM means that the MRC score of GM is 4 or less. Its complementary sign, weak ilopsoas with normal GM, means that the MRC score of ilopsoas is 4 or less, whereas that of GM is 5. Thirty-one patients with FW and 72 patients with SW were enrolled. The weak GM sign was positive in all 31 patients with FW and in 11 patients with SW, that is, 100% sensitivity and 85% specificity. Therefore, the complementary sign, weak iliopsoas with normal GM, was 100% specific for SW. Although 100% should be discounted considering limitations of this study, these signs will likely be helpful in differentiating between FW and SW in the general neurology setting. Downward pressing of the lower limb to the bed in the supine position is interpreted by the patient as an active movement exerted with an effort and might be preferentially impaired in FW.

A systematic approach toward waste management: Problem-oriented Innovation System (PIS)

ABSTRACT The production of waste and the concerns about their ecological and environmental damages are among the grand challenges societies have faced. Therefore, policymakers should highlight effective waste management as one of the pillars of sustainable development. However, the previous frameworks for managing the waste problem have been mainly unsystematic as they neglected the social aspects of the problem in analysing technology development and innovation. Therefore, in this article, the status-quo of Tehran’s waste problem (as a case study) was analysed with the new approach of ‘Problem-oriented Innovation System (PIS),’ and policy recommendations are presented accordingly. The research methodology is content analysis of related documents and reports based on a 5-step process. Findings indicate that the weak performance of Tehran’s solid waste management originates at the beginning of the waste management cycle and the weak functions of public awareness, standardisation, market formation, and system monitoring guidance. Accordingly, the unstable patterns of industrial production and social behaviour lead to the supply of a large amount of unnecessary and uneconomical waste, and the system’s actors are incapable of guiding the system and standardising to change the patterns.

Self-control training supplementing inpatient multidisciplinary obesity treatment in children and adolescents

Research points to self-control as a possible mechanism for facilitating health behaviour and weight loss. The dual pathway model underpins the role of strong bottom-up reactivity towards food and weak top-down executive functions in obesity. Despite flourishing lab studies on attention bias modification or inhibition trainings, relatively few focused on training both processes to improve self-control in children and adolescents in inpatient multidisciplinary obesity treatment (MOT).Being part of the WELCOME project, this study investigated the effectiveness of Brain Fitness training (using the Dot Probe and Go/No-Go) as an adjunct to inpatient MOT in 131 Belgian children and adolescents. Changes in self-control (performance-based inhibitory control and attention bias as well as self-reported eating behaviour) in the experimental group were compared to sham training. Multiple Imputation was used to handle missing data.Inhibitory control and external eating improved over time (pre/post/follow-up), but we found no evidence for a significant interaction between time and condition. Future research should pay more attention to the role of individual variability in baseline self-control, sham training, and ecological validity of self-control training to improve real-life health behaviour and treatment perspectives for children and adolescents with weight problems.

181. Novel Method Of Double Innervated Free Gracilis Muscle Functional Transfer For Facial Reanimation

PURPOSE: Dynamic facial reanimation is the gold standard treatment for a paralyzed face. The use of the cross-face nerve graft (CFNG) in combination with the masseteric nerve to innervate the free gracilis muscle has been reported, with the goal of providing both spontaneity from the CFNG and strong neural input from the masseteric nerve. We report a series of patients who underwent a novel modification to the existing nerve coaptation configurations. METHODS: Eight patients (Image 1 below) received free gracilis muscle transfer using the new double innervation method between September 2014 and December 2017. The CFNG, which was performed nine months prior, was sutured in an end-to-end fashion to the obturator nerve. A nerve graft was coapted to the ipsilateral masseteric nerve and then sutured in an end-to-side fashion to the CFNG proximal to the end-to-end obturator coaptation (Image 2 below). RESULT: All patients recovered smile function with teeth clenching (average 7.5 months, range 3-12). Seven of eight patients recovered a strong spontaneous smile by an average of 8.9 months (range 7-12), with one patient having weak spontaneous function after 12 months of follow-up. Average follow-up time was 31.52 months. All patients achieved improvements in their smile excursion based on the FACE-Gram software. Smile with or without biting achieved similar excursion on average (7.91mm vs.8.04mm, p=0.93). CONCLUSION: Our novel method of a double-innervated free gracilis muscle transfer represents a viable technique that does not risk denervation of the gracilis muscle and provides a symmetric, spontaneous, emotional smile.

Gait Device Treatment Using Telehealth for Individuals With Stroke During the COVID-19 Pandemic: Nonrandomized Pilot Feasibility Study.

During the COVID-19 pandemic, rehabilitation providers and consumers adopted telehealth practices at unprecedented rates. Multiple prepandemic studies demonstrate the feasibility and comparable efficacy between in-clinic and remote treatment for certain impairments caused by stroke, such as upper extremity weakness and impaired motor function. However, less guidance has been available regarding gait assessment and treatment. Despite this limitation, safe and effective gait treatment is fundamental to optimizing health and well-being after stroke and should be considered a treatment priority, including during the COVID-19 pandemic. This study explores the feasibility of using telehealth to deliver gait treatment using a wearable gait device, the iStride device, to stroke survivors during the 2020 pandemic. The gait device is used to treat hemiparetic gait impairments caused by stroke. The device alters the user's gait mechanics and creates a subtle destabilization of the nonparetic limb; therefore, supervision is required during its usage. Before the pandemic, treatment with the gait device had been provided in person to appropriate candidates using a combination of physical therapists and trained personnel. However, upon the emergence of the COVID-19 pandemic, in-person treatment was halted in adherence to pandemic guidelines. This study investigates the feasibility of 2 remote delivery treatment models with the gait device for stroke survivors. Participants were recruited during the first half of 2020 after the onset of the pandemic and included 5 individuals with chronic stroke (mean age 72 years; 84 months post stroke). Four participants were previous gait device users who transitioned to the telehealth delivery model to continue their gait treatment remotely. The fifth participant performed all study-related activities, from recruitment through follow-up, remotely. The protocol included virtual training for the at-home care partner, followed by 3 months of remote treatment with the gait device. Participants were instructed to wear gait sensors during all treatment activities. To assess feasibility, we monitored the safety of the remote treatment, compliance with protocol activities, acceptability of the telehealth treatment delivery, and preliminary efficacy of the gait treatment. Functional improvement was measured using the 10-Meter Walk Test, the Timed Up and Go Test, and the 6-Minute Walk Test, and quality of life was assessed using the Stroke-Specific Quality of Life Scale. No serious adverse events occurred, and participants rated high acceptance of the telehealth delivery. Protocol compliance averaged 95% of treatment sessions, 100% of assessments, and 85% of sensor usage during treatment. After 3 months of treatment, the average improvement in each functional outcome exceeded the minimal clinically important difference or minimal detectable change value. Remote treatment delivery with the gait device appeared feasible with care partner support. Gait treatment using telehealth may be useful to offset negative immobility impacts for those requiring or preferring remote care during the pandemic or otherwise. ClinicalTrials.gov NCT04434313; https://clinicaltrials.gov/ct2/show/NCT04434313.

Analisis Penerapan Good Corporate Governance Dan Budaya Lokal Dalam Tata Kelola Keuangan LPD

This study aims to determine (1) the factors causing fraud in the LPD, (2) the implementation of good corporate governance in financial governance in the LPD, and (3) the application of local culture used in financial governance at the LPD Dawan Widang Kelod. This research use desciptive qualitative approach. This study utilizes primary and secondary data collected through interviews, observations, documentation, and literature reviews. The findings of this study reveal that the elements that contribute to LPD fraud are weak organizational structures, weak supervisory functions, absence of a system or refusal to use the system, weak LPD governance, the presence of a ewuh pakewuh culture, and low-quality human resources. Good financial governance practices have not been implemented in LPD Dawan Widang Kelod such as transparency, accountability, responsibility, independence, equality and fairness which are not in accordance with the provisions. LPD Dawan Widang Kelod has implemented the local culture of Tri Kaya Parisudha which can shape the character and integrity of human resources. However, in its implementation it has not been implemented optimally to achieve good financial governance

Optimal algorithms for differentially private stochastic monotone variational inequalities and saddle-point problems

In this work, we conduct the first systematic study of stochastic variational inequality (SVI) and stochastic saddle point (SSP) problems under the constraint of differential privacy (DP). We propose two algorithms: Noisy Stochastic Extragradient (NSEG) and Noisy Inexact Stochastic Proximal Point (NISPP). We show that a stochastic approximation variant of these algorithms attains risk bounds vanishing as a function of the dataset size, with respect to the strong gap function; and a sampling with replacement variant achieves optimal risk bounds with respect to a weak gap function. We also show lower bounds of the same order on weak gap function. Hence, our algorithms are optimal. Key to our analysis is the investigation of algorithmic stability bounds, both of which are new even in the nonprivate case. The dependence of the running time of the sampling with replacement algorithms, with respect to the dataset size n, is n2\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$n^2$$\\end{document} for NSEG and O~(n3/2)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${\\widetilde{O}}(n^{3/2})$$\\end{document} for NISPP.

Superpolynomial quantum-classical separation for density modeling

Density modelling is the task of learning an unknown probability density function from samples, and is one of the central problems of unsupervised machine learning. In this work, we show that there exists a density modelling problem for which fault-tolerant quantum computers can offer a super-polynomial advantage over classical learning algorithms, given standard cryptographic assumptions. Along the way, we provide a variety of additional results and insights, of potential interest for proving future distribution learning separations between quantum and classical learning algorithms. Specifically, we (a) provide an overview of the relationships between hardness results in supervised learning and distribution learning, and (b) show that any weak pseudo-random function can be used to construct a classically hard density modelling problem. The latter result opens up the possibility of proving quantum-classical separations for density modelling based on weaker assumptions than those necessary for pseudo-random functions.

Statistics of electron-multiplying charge-coupled devices

Electron-multiplying charge-coupled devices are efficient imaging devices for low-surface-brightness ultraviolet astronomy from space. The large amplification allows photon counting (PC), the detection of events versus nonevents. This paper provides the statistics of the observation process, the photon-counting process, the amplification process, and the compression. The expression for the signal-to-noise of PC is written in terms of the polygamma function. The optimal exposure time is a function of the clock-induced charge. The exact distribution of amplification process is a simple-to-compute powered matrix. The optimal cutoff for comparing to the read noise is close to a strong function of the read noise and a weak function of the electron-multiplying gain and photon rate. A formula gives the expected compression rate.

Size dependent free vibration analysis of 2D-functionally graded curved nanobeam by meshless method

The free vibration of two-directional functionally graded (2D-FG) thick curved nanobeam with concentrated mass is investigated for various boundary conditions. Hamilton’s principle is employed to develop the governing equations of the 2D-FG curved nanobeam using the first-order shear deformation theory (FSDT). The small scale effect is captured by the nonlocal elasticity theory of Eringen. The nanobeam is functionally graded in the transverse and circumferential directions of the curved nanobeam. The governing equations of the system are obtained as three coupled partial differential equations with non-constant coefficients. An appropriate meshless formulation is developed to discretize the governing equations based on local weak formulation and radial basis function. The presented meshless method is employed to study the free vibration of the one-directional and two-directional functional graded curved nanobeams. Simple-simple, free-free, clamped-clamped, and clamped-free edge conditions are investigated. Moreover, an analytical solution is developed for simple-simple transversely 1D-FG curved nanobeam. In the numerical results, the natural frequencies and mode shapes of shadow and deep curved nanobeam are studied and the influence of effective parameters such as nonlocal parameter, FG power indexes, opening angle, edge conditions, and concentrated mass are investigated. It is seen that shear locking effect is eliminated in present meshless formulation.

Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.

The PRDM family transcription repressor Blimp-1 is present in almost all multicellular organisms and plays important roles in various developmental processes. This factor has several conserved motifs among different species, but the function of each motif is unclear. Drosophila Blimp-1 plays an important role in determining pupation timing by acting as an unstable transcriptional repressor of the βftz-f1 gene. Thus, Drosophila provides a good system for analyzing the molecular and biological functions of each region in Blimp-1. Various Blimp-1 mutants carrying deletions at the conserved motifs were induced under the control of the heat shock promoter in prepupae, and the expression patterns of βFTZ-F1 and Blimp-1 and pupation timing were observed. The results showed that the regions with strong and weak repressor functions exist within the proline-rich middle section of the factor and near the N-terminal conserved motif, respectively. Rapid degradation was supported by multiple regions that were mainly located in a large proline-rich region. Results revealed that pupation timing was affected by the repression ability and stability of Blimp-1. This suggests that both the repression function and instability of Blimp-1 are indispensable for the precise determination of pupation timing.

Хятад хэлний сул хөг

This article presents a study of the origin, derivation and alteration of the Chinese words with the weak harmony, the feature and specific function of the weak harmony, the relevant views and publications of the linguistic scientists on discussing whether the fifth harmony of the Chinese language is the weak harmony, the role of the weak harmony in the Chinese language speech also the relationship of the weak harmony with lexicology and grammar. Furthermore, we discussed the results of the previous research, the benefit of studying the weak harmony for the Chinese language learners and provided a list of 200 essential words which foreign language learners have to acquire.

Tuberoplasty: Indications, Technique, and Preliminary Results

The optimal approach to treatment of massive irreparable rotator cuff tears (MIRCTs) continues to be debated among shoulder surgeons. While nonsurgical treatment is a reasonable option for some, many of these patients continue to experience pain, weakness, and overall limited function of the shoulder [1], [2]. Superior capsular reconstruction has become a widely accepted approach to treatment of MIRCT, however there exists several technical and biologic challenges of this technique. Overcoming many of these difficulties, a recently described technique involves the placement of a biological interpositional graft over the greater tuberosity which acts as a permanent spacer between the humerus and acromion[3]. With the primary goal of providing pain relief, this technique may function to improve the benefit of rehab following MIRCT. In this article, we describe the indications, technique, and early outcomes of this so-called “tuberoplasty” approach to MIRCT.

Inhibitory effect of baricitinib on microglia and STAT3 in a region with a weak blood-brain barrier in a mouse model of rheumatoid arthritis.

In patients with RA, baricitinib not only improves arthritis symptom severity, but also patients' neuropsychological symptoms, such as depression and fatigue. However, the cellular mechanisms through which baricitinib can affect neural activity is unexplored. While the blood-brain barrier (BBB) permeability of this drug remains unclear, Janus kinase inhibitors (JAKi) might reach the area postrema, which is a unique brain region with a weak BBB function. Our recent study demonstrated microglial activation during experimental arthritis in the area postrema. Therefore, we sought to assess the effect of baricitinib on microglia in the area postrema using the CIA mouse model. Microglia number and morphology in the area postrema were assessed by immunostaining for ionized calcium-binding adaptor molecule-1 (Iba-1). Data were collected on post-immunization day 35 (early phase) and 84 (late phase), and compared between baricitinib- and vehicle-treated mice. The effect on signal transducers and activators of transcription (STAT3) in the area postrema was also immunohistochemically examined. Behavioural outcomes were assessed by examining feeding behaviours and sucrose preference tests. In the early phase, activated microglial levels in the area postrema were decreased by baricitinib, accompanied by the inhibition of phosphorylated-STAT3 and recovery of food intake and sucrose preference. On the other hand, baricitinib did not affect microglial morphology in the late phase. Our results demonstrate that baricitinib can affect brain cells, specifically microglia, in the brain region with a weak BBB and mitigate aberrant behaviours during autoimmune arthritis, pointing to the potential therapeutic effect of JAKi on brain pathologies underpinning RA.