In this paper, to the best of our knowledge, we propose the combination communication regime for the first time, which uses the spatial position combination of different physical entities, rather than the change of physical parameters, to represent the information. Based on theoretical analysis, several innovative combination communication modes are presented and mathematically analyzed. The result shows that the proposed combination communication modes can effectively enhance the flexibility and transmission efficiency of the communication system, in comparison with existing spatial modulation schemes. Combination communication can address certain specific dilemmas in the traditional Shannon-Nyquist communication regime, e.g., reducing channel crosstalk in the WDM system, while achieving channel capacity beyond the expected level.