The article analyzes aspects of innovative activity of enterprises and some elements of their investment support in the current conditions of increasing the influence of globalization processes and determining the comparative advantages of the region, since the introduction of innovative products is a basis for effective development of the enterprise, region and country as a whole. The analysis of the main indicators characterizing the level of innovative activity and innovation activity of the enterprises of Lviv region, in particular the volume of performed scientific and technical works; the share of enterprises that introduced innovations; volumes and structure of sources of financing of innovation activity in the Lviv region, volumes of expenses for innovative activity of enterprises and direct foreign investments into the economy of Lviv region. The peculiarities of the innovation process at the regional level are characterized and directions of activation of investment and innovation activity taking into account the comparative advantages of the region on the basis of SWOT-analysis with the definition of strengths and weaknesses and the use of opportunities and the avoidance of threats are proposed; use of foreign economic potential of the region, its borderline location and export-oriented production. The development of innovative potential and expansion of the ways of its investment support are one of the factors that play a crucial role in ensuring a comprehensive balanced development of the region, building strategic prospects for its economic growth, identifying internal problems and obstacles that hinder really assess the potential of existing ones at the local levels of development resources. The implementation of regional innovation policy involves the use of methodological approaches that ensure the coordination of the interests of economic entities in the territory with the objectives of its economic and social development. A key role in ensuring innovation activity is the choice of a particular strategy for innovation development and its implementation, as well as the level of availability of various resources in the innovation sector and the quality of management. The issue of investment and financial provision of innovative development of enterprises of the region and the search for ways of alternative financing, information awareness of enterprise management in the innovation sphere and the possibilities of adjusting the process of their application in practical activities remain relevant.