Syzygium Samarangense Research Articles

Desenvolvimento do conteúdo de carboidratos,flavonoides, antocianinas, fenóis totais,clorofila e minerais (K+) de maçã de cera afetada por CPPU e NAA usando tecnologia de zaragatoa

Abstract The study was conducted to investigate the effect of CPPU(2-Chloro-4-pyridyl-phenylurea) and NAA (Naphthaleneacetic acid) on the pigments, total phenol, flavonoid and mineral (K+) content in wax apple fruit. CPPU concentrations were 10, 15 and 20ppm (Expt.1) and 6, 12, 18ppm NAA were applied coming after swabbing technique (Expt.2). In Expt.1, the lowest fruit weight, fruit size and chlorophyll content was observed in control treatment. However, the highest fruit weight, fruit size and chlorophyll (SPAD) content was found in 15ppm CPPU. The most effective concentration was 15ppm CPPU for the earlier fruit maturity (color development) compared to other concentrations. Moreover, flavonoid, fructose, inverted sugar, total phenol and K+ were higher in 15ppm CPPU than control, 10 and 20ppm CPPU. In addition, anthocyanin was found increasing trend while developing the fruit maturity represented by color development. In Expt.2, chlorophyll was higher in 15ppm CPPU than control, 6, 18ppm NAA. Furthermore, flavonoid, fructose, inverted sugar, total phenol and K+ content were higher in 12ppm NAA than control, 6 and 18ppm NAA. Besides, the maximum anthocyanin was found in 12ppm NAA. Finally it seemed that 15ppm CPPU and 12ppm NAA were the best concentration for fruit growth and biochemical contents development in wax apple.

Phytochemical Screening of Bioactive Compounds and Antimicrobial Activity of Different Extracts of Syzygium samarangense Leaves

Phytochemical Screening of Bioactive Compounds and Antimicrobial Activity of Different Extracts of Syzygium samarangense Leaves

PENGARUH PENAMBAHAN DAUN ANTIMIKROBA DAN MODIFIKASI PENYIMPANAN TERHADAP ORGANOLEPTIK LEMANG DALAM MEMPERTAHANKAN UMUR SIMPAN

Lemang is one of malay culinary that was served at ceremonies, eid and etc. Lemang was made from glutinous rice and coconut milk. It was grilled on embers, but it was very easy deterioration. Antimicroba leaves and bamboo storage position was one of experiment to make lemang be survive, but antimicroba leaves had its own characteristics like color, taste, and texture. So, the object of this research was analyze effect antimicroba leaves addition (Pandanus amayllifolius Roxb, Syzygium samarangense and Mangifera indica) and storage modification (normal position and flipped position) to characteristic of lemang organoleptic characteristic. The characteristic of lemang organoleptic was tested by organoleptic test for 30 panelists. The panelists gave score 1 if they dislike, scored 2 if they feel usual, and scored 3 if they feel very like for 7 days. The scored was calculated by Analysis sidik ragam and Beda Nyata Terkecil. The result showed that all treatment gave real effect to aroma, texture and taste to lemang. The all of lemang in normal storage position treatment had dislike scores at the 3rd day. While lemang in flipped storage position treatment had dislike score at the 5th day. The best leaves that for addition lemang processing was Pandanus amayllifolius Roxb. It gave stable aroma, texture and dark color for lemang

ANTI-INFLAMMATORY ACTIVITY OF STEM BARK DICHLOROMETHANE FRACTION Syzygium samarangense EXTRACT AS COX-2 INHIBITOR: A BIOINFORMATICS APPROACH

Syzygium samarangense is a plant that is rich in flavonoid compounds. Previous researchrevealed that the dichloromethane fraction from the stem bark extract contained fourbioactive compounds, namely, pinocembrin, uvangoletin, stercurensin, and aurentiacin,which had good antioxidant activity. However, research on the potential of these fourcompounds as an anti-inflammatory has not been revealed. This study aims to continueprevious research in revealing the potential of compounds in the dichloromethane fractionof S. samarangense extract as an anti-inflammatory agent in silico COX-2 inhibitors. Thisstudy uses in silico biocomputation, including drug-likeness analysis and molecular dockinganalysis using COX-2 protein and the control drug rofecoxib. The results showed that thereare compounds that have the potential as anti-inflammatory compounds, namelypinocembrin. However, further studies, such as in vitro and in vivo, are still needed to revealits potential as an anti-inflammatory agent

In Vitro and In Silico Pharmacological and Cosmeceutical Potential of Ten Essential Oils from Aromatic Medicinal Plants from the Mascarene Islands.

In this study, 10 essential oils (EOs), from nine plants (Cinnamomum camphora, Curcuma longa, Citrus aurantium, Morinda citrifolia, Petroselinum crispum, Plectranthus amboinicus, Pittosporum senacia, Syzygium coriaceum, and Syzygium samarangense) were assessed for their antimicrobial, antiaging and antiproliferative properties. While only S. coriaceum, P. amboinicus (MIC: 0.50 mg/mL) and M. citrifolia (MIC: 2 mg/mL) EOs showed activity against Cutibacterium acnes, all EOs except S. samarangense EO demonstrated activity against Mycobacterium smegmatis (MIC: 0.125-0.50 mg/mL). The EOs were either fungistatic or fungicidal against one or both tested Candida species with minimum inhibitory/fungicidal concentrations of 0.016-32 mg/mL. The EOs also inhibited one or both key enzymes involved in skin aging, elastase and collagenase (IC50: 89.22-459.2 µg/mL; 0.17-0.18 mg/mL, respectively). Turmerone, previously identified in the C. longa EO, showed the highest binding affinity with the enzymes (binding energy: -5.11 and -6.64 kcal/mol). Only C. aurantium leaf, C. longa, P. amboinicus, P. senacia, S. coriaceum, and S. samarangense EOs were cytotoxic to the human malignant melanoma cells, UCT-MEL1 (IC50: 88.91-277.25 µg/mL). All the EOs, except M. citrifolia EO, were also cytotoxic to the human keratinocytes non-tumorigenic cells, HaCat (IC50: 33.73-250.90 µg/mL). Altogether, some interesting therapeutic properties of the EOs of pharmacological/cosmeceutical interests were observed, which warrants further investigations.

A colorimetric smartphone-based sensor for on-site AA detection in tropical fruits using Fe-P/N[sbnd]C single-atom nanoenzyme

Ascorbic acid is one of the important vitamins to maintain human life activities and plays an irreplaceable role in regulating human redox metabolism. Fresh fruit can provide plenty of AA to maintain human metabolic balance. Thus, it is great significant to develop a rapid and convenient method for detection of AA to evaluate the freshness and nutritional quality of fruits. In this work, Fe single-atom nanoenzyme (Fe-SAN) based colorimetric sensor assisted with smartphone was designed for rapid and on-site AA detection in tropical fruits. Firstly, Fe-SAN with high oxidase-mimicking activity was synthesized by using green tea leaves as sources of carbon and nitrogen and NaH2PO2 as P source to obtain Fe-P/NC SAN, in which P was used to reconstruct the distribution of electronic to enhance the oxidase-mimicking activity of Fe-SAN. Besides, the as-synthesized Fe-P/NC SAN with remarkable oxidase-like activities could oxidize 3,3́,5,5́-tetramethylbenzidine (TMB) to blue colored oxidized TMB. AA could inhibit the oxidation of TMB, leading to blue fading. Based on the above principle, colorimetric sensor integrated with smartphone RGB mode was fabricated and exhibited a good linear detection range (0.5–100 μM) and low detection limit of 0.315 μM for AA detection under optimal conditions.More importantly, the developed sensor could rapidly and accurately detect AA in real sample, such as pineapple, wax apple and mango. Therefore, this research provides a new cost-effective method for the efficient and exact detection of AA in tropical fruit, which has a broad application prospect.

Development of Meso- and Macro-Pore Carbonization Technology from Biochar in Treating the Stumps of Representative Trees in Taiwan

This study uses the tree stumps of the three representative trees in Taiwan (Leucaena leucocephala, Syzygium samarangense, and Ziziphus jujuba) as the material source and recyclable oyster shell powder as an activator. A carbonization process for upgrading and recycling the tree stumps was developed with our homemade, digital-controlled, energy-saving carbonization system. First, the tree stumps are carbonized at a medium temperature of 500 °C and then heated to 900 °C for high-temperature carbonization, followed by the activation procedure as required. With our method, we can produce biochar with a high proportion of fixed carbon and a high proportion of meso- and macropores while maximizing the yield of wood vinegar. The specific surface area of the meso- and macropores can reach up to 70 m2/g or more. The effect of different activation materials on the pore characteristics and specific surface area of biochar was carefully examined. It was found that both KOH and oyster shell powder is the ideal activator for producing biochar with a high proportion of meso- and macropores. The FTIR spectrum, CEC, and contents of the ordinary elements and heavy metals of the biochar were also reported. It is clear from the FTIR data that the absorption peaks of the overall spectrum of the three types of biochar after carbonization at high temperature are cleaner than those of biochar carbonized at low temperature. This research can promote the recycling of agricultural residues, enhance soil carbon sequestration, preserve fertilizers, and suppress diseases and pests, moving towards approaching the goal of net-zero carbon emissions.

First Report of 'Candidatus Phytoplasma asteris' (16SrI group) Associated with Murraya exotica Witches'-Broom Disease in Taiwan.

Murraya exotica L., commonly known as orange jasmine, is an evergreen shrub belonging to the Rutaceae family. It has long been used as traditional Chinese medicine for treating abdominal pain, toothache, scabies, and other disorders (Liu et al. 2018). M. exotica is widely grown as a garden bush in Taiwan. A prokaryotic pathogen, 'Candidatus Liberibacter asiaticus' (Damsteegt et al. 2010), reportedly could infect M. exotica, but there is no reported phytoplasma disease in M. exotica. In June 2020, M. exotica plants exhibiting witches'-broom (WB), leaf yellowing, and small leaves (Fig. s1) were observed in a horticultural landscaping field in Taichung City, Taiwan. It was estimated that more than 70% of M. exotica plants within a single area were affected. DNA was extracted separately from petioles of five symptomatic and one asymptomatic plants using a modified CTAB method (Echevarría-Machado et al. 2005) and used for nested PCR with two universal primers, P1 (Deng and Hiruki 1991)/P7 (Schneider et al. 1995) followed by R16F2n/R16R2 (Gundersen and Lee 1996) to amplify a 1.2-kb 16S rRNA fragment. PCR was also conducted by primers, rp(I)F1A/rp(I)R1A to amplify a partial ribosomal protein S3 and L22 (rplV-rpsC) fragment (Lee et al. 2004). Expected 1.2-kb bands were amplified from DNA extracted from all symptomatic plants, whereas no bands were amplified from that of the asymptomatic plant. The amplicons were cloned, sequenced with an ABI 3730 automatic sequencer (Applied Biosystems, Hammonton, NJ, USA) in Biotechnology Centre DNA-sequencing facility at National Chung Hsing University (NCHU) and deposited in GenBank. BLAST analysis revealed that 16S rDNA sequences (MZ373297 and MZ373298) shared 100% identity to each other and both shared 99.4% identity with those of several phytoplasma strains, e.g., rapeseed phyllody phytoplasma (CP055264), Brassica sp. phyllody phytoplasma (MN877914), Plumbago auriculata leaf yellowing phytoplasma (MN239504), and aster yellows phytoplasma (MK992774), which all belonging to the 16SrI group, by using the CLUSTAL W Methods of MegAlign program (DNASTAR, Inc., Madison, WI, USA). Further analysis using iPhyClassifier tool (https://plantpathology.ba.ars.usda.gov) indicated that the virtual restriction fragment length polymorphism (RFLP) patterns derived from the 16S rDNA F2nR2 fragment of the M. exotica WB phytoplasma was most similar to the reference pattern of the 16SrI-B subgroup, with a pattern similarity coefficient of 0.97 and shared 99.3% sequence identity to 'Candidatus Phytoplasma asteris' (M30790). The partial rplV-rpsC gene sequence (OM275408) showed 99.7% of sequence identities to those of rapeseed phyllody phytoplasma (CP055264), plum witches'-broom phytoplasma (MH061366) and oilseed rape phytoplasma (KX551965), by using the CLUSTAL W Methods of MegAlign program. Taken together, we concluded that the phytoplasma strain associated with M. exotica WB disease was a strain belonging to a 16SrI. To the best of our knowledge, this is the first report of M. exotica being infected by a phytoplasma in the aster yellows group, and M. exotica may also serve as an intermediate reservoir host to other plants, e.g., wax apple, periwinkle and roselle, of 16SrI phytoplasma.

Vasorelaxant Effects of Syzygium samarangense (Blume) Merr. and L.M.Perry Extract Are Mediated by NO/cGMP Pathway in Isolated Rat Thoracic Aorta.

Syzygium samarangense (Blume) Merr. and L.M.Perry is utilized widely in traditional medicine. We have reported previously a wide array of pharmacological properties of its leaf extract, among them anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, antiulcer, and antitrypanosomal activities. We also annotated its chemical composition using LC-MS/MS. Here, we continue our investigations and evaluate the vasorelaxant effects of the leaf extract on aortic rings isolated from rats and explore the possible underlying mechanisms. S. samarangense extract induced a concentration dependent relaxation of the phenylephrine-precontracted aorta in the rat model. However, this effect disappeared upon removing the functional endothelium. Pretreating the aortic tissues either with propranolol or NG-nitro-L-arginine methyl ester inhibited the relaxation induced by the extract; however, atropine did not affect the extract-induced vasodilation. Meanwhile, adenylate cyclase inhibitor, MDL; specific guanylate cyclase inhibitor, ODQ; high extracellular KCl; and indomethacin as cyclooxygenase inhibitor inhibited the extract-induced vasodilation. On the other hand, incubation of S. samarangense extract with aortae sections having their intact endothelium pre-constricted using phenylephrine or KCl in media free of Ca2+ showed no effect on the constriction of the aortae vessels induced by Ca2+. Taken together, the present study suggests that S. samarangense extract dilates isolated aortic rings via endothelium-dependent nitric oxide (NO)/cGMP signaling. The observed biological effects could be attributed to its rich secondary metabolites. The specific mechanisms of the active ingredients of S. samarangense extract await further investigations.

In vitro antifungal properties of Aloe vera (L.) Burm. f. films incorporated with cinnamon essential oil against Lasiodoplodia theobromae in wax apple

In vitro antifungal properties of Aloe vera (L.) Burm. f. films incorporated with cinnamon essential oil against Lasiodoplodia theobromae in wax apple

Biophysical Characterization of Autochthonous and New Apple Cultivar Surfaces

Apples have long been known for their beneficial effects on human health due to the presence of various bioactive compounds. It is therefore very important to understand the biophysical properties of apple cuticle that dictate apples’ storability and quality. The purpose of this work was to determine the roughness, hydrophobicity, surface potential, and color of various autochthonous and new apple cultivars. The surface roughness was measured by optical profilometer, hydrophobicity by tensiometer, zeta potential by electro kinetic analyser, and surface color by chroma meter. Measurements reveal that the new cultivar Elstar has the roughest surface while the autochthonous cultivar Crown Prince Rudolph has the lowest roughness. Under normal physiological conditions, all apple surfaces were negatively charged, with Wax apple having the lowest and Crown Prince Rudolph the highest values; most cultivars had an isoelectric point at around pH = 3. The surfaces of the new cultivars were slightly more hydrophobic than those of the autochthonous. We conclude that autochthonous and new apple cultivars differ in biophysical surface properties, which might impact transpiration, bacterial/fungi adhesion and, consequently, apple storage and shelf life potential.

Syzysamalactone, an Unusual 11-Carbon δ-Lactone Derivative from the Fresh Ripe Fruits of Syzygium samarangense (Wax Apple).

To study the chemical constituents from the ripe fresh fruits of Syzygium samarangense (wax apple) and their potential health effects, a phytochemical investigation was undertaken. A new δ-lactone derivative, syzysamalactone (1), along with a known biogenetically related δ-lactone derivative, 6-pentyl-α-pyrone (2), were isolated from the fresh ripe fruits of S. samarangense. Syzysamalactone (1) is an unusual 11-carbon δ-lactone derivative, and its chemical structure and absolute configuration were elucidated by spectroscopic data analysis. A plausible biogenetic pathway for 1 was also proposed. Furthermore, the potential neuroprotective effects of compounds 1 and 2 were assessed. As a result, compounds 1 and 2 displayed notable neuroprotective effects with EC50 values of 0.29 ± 0.03 and 1.28 ± 0.06 μM, respectively, using the SH-SY5Y human neuroblastoma cell line. This is the first report of δ-lactone derivatives showing significant neuroprotective activities.

Wax apple (Syzygiumsamarangense) fruit extract ameliorates endothelial dysfunction and liver damage in high cholesterol diet-fed rats

Background and aimWax apple fruit (Syzygium samarangense) is one of the most popular tropical fruit in Asia, and contains several essential nutrients. Therefore, this study explored the effects of the wax apple fruit extract on a high-cholesterol diet-induced vascular endothelial dysfunction and fatty liver in rats. Experimental procedureMale Sprague Dawley rats were fed a diet with 1.5% cholesterol (HCD) for 8 weeks, and were given wax apple fruit extract (50 and 100 mg/kg/day) orally for the last 4 weeks. After 8 weeks, blood sample, thoracic aorta, and liver were collected and processed for biochemical and histological analysis. Additionally, vascular endothelial function and the protein expression of oxidative stress markers in aortae were evaluated. Results and conclusionWax apple reduced serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST), and alanine aminotransferase (ALT), but increased high-density lipoprotein cholesterol (HDL-C) levels. Furthermore, the liver levels of TG and TC were reduced in wax apple-treated hypercholesterolemic rats. Histological studies revealed that wax apple ameliorated HCD-induced morphologic changes of aortic and liver tissues of rats. In aortic tissues, the impaired endothelium-dependent responses to acetylcholine, the reduced nitric oxide (NO) contents, the elevated endothelin (ET)-1 contents, and the increased expression of NADPH oxidase subunit p47phox and 4-hydroxynonenal in HCD-fed rats were reversed by wax apple treatment. These results suggest that oral administration of wax apple improves vascular dysfunction and damage in hypercholesterolemic rats possibly through increasing NO bioavailability, decreasing ET-1 levels and reducing oxidative stress. Furthermore, wax apple ameliorates the HCD-induced fatty liver in rats.

Green synthesis of nano-silver using Syzygium samarangense flower extract for multifaceted applications in biomedical and photocatalytic degradation of methylene blue

Green synthesis of nano-silver using Syzygium samarangense flower extract for multifaceted applications in biomedical and photocatalytic degradation of methylene blue

Investigation of pest species and population dynamics of the oriental fruit fly, Bactrocera dorsalis (Hendel, 1912), in the water apple gardens in different seasons, Caolanh city, Dongthap province

Twenty-six species of insect pests belonging to thirteen families, eight orders were identified after the surveys in some gardens of the water apple (Syzygium samarangense) in Hoa An Commune of Caolanh city, Dongthap province, Southern Vietnam. Some species of the pests, e.g., Aleuroclava aucubae, Trialeurodes lauri, Trichopsocus clarus, are new recorded in Vietnam. The oriental fruit fly Bactrocera dorsalis is one of the major pest species devastating the water apple. Rainfall is a factor comprehensively influencing the population fluctuation of the oriental fruit fly. The pest population was exploded in the dry season, but reduced remarkably in the rainy season. The fruiting period from February to April was regarded as another major factor influencing the oriental fruit fly population in that area. The results provide scientific data for establishing practical management strategy for the fly under the particular geographical and climatic conditions, especially for the oriental fruit fly Bactrocera dorsalis.

Antibacterial Activities of Pentaclethra Macrophylla and Syzygium Samarangense against Opportunistic Bacteria Pathogens

In this study, Pentaclethra macrophylla and Syzygium samarangense leaves was tested for their antibacterial activities against selected opportunistic bacterial strains. The crude extracts of the plants were extracted using methanol and fractionated into hexane, ethyl acetate and aqueous fractions. The antibacterial activity of the leaves against B. subtilis (ATCC® 6633™), S. aureus (ATCC® 25923™), E. coli (ATCC® 25922™), P. aeruginosa (ATCC® 9027™) was performed using the agar well diffusion technique at 20mg/ml extracts fractions. All plants extracts extract exhibited some antibacterial activity against at least one bacterial strain. P. macrophylla exhibited the highest inhibition against E. coli (25mm) compared to B. subtilis, S. aureus and P. aeruginosa. Similar observation was noted for S. samarangense where the highest inhibition was against E. coli (22mm). In conclusion, P. macrophylla and S. samaragense exhibited antibacterial activities against the selected bacteria. The ethyl acetate and aqueous extracts of both plants had the highest antibacterial activities. This indicates that P. macrophylla and S. samrangense leaves could be a source of antibacterial agent in overcoming antibacterial drug resistance.

Structural and Physicomechanical Properties of an Active Film Based on Potato Starch, Silver Nanoparticles, and Rose Apple (Syzygium samarangense) Extract

In the current research work, active films were made from potato starch (PS) and AgNP solution comprising of silver nanoparticles (AgNPs) and rose apple extract (RE) via the casting method at various concentrations. AgNP solution in the PS matrix significantly altered the physical properties such as opacity, water vapor permeability mechanical property, solubility, and swelling index of the films. The influence of AgNP solution on the properties of the films was deeply examined. The results found that the 15% AgNP solution films exhibited better physicochemical properties. The presence of AgNP solution in the PS matrix significantly improved the properties of active films which is evident from the results of FTIR and SEM. Results show that AgNPs and PS were uniformly mixed and formed continuous and homogenous films without bubbles and cracks. In addition, the AgNP solution in the films significantly improved the antibacterial activity against S. aureus than P. aeruginosa in the films.

Phytochemical Analysis and Repellent Activity of Annona Muricata and Syzygium Samarangense Leaves Against Sitophilus Oryzae

The present study is conducted to control the stored pest grain - Sitophilus oryzae using plant leaves, such as Annona muricata and Syzygium samarangense. Extraction of selected leaves were done using organic solvents such as Methanol and petroleum ether. Qualitative phytochemical analysis of selected plant leaves revealed the presence of secondary metabolites such as Alkaloids, Flavonoids, Tannins, Saponins, Glycerides, Steroids, Terpenoids, Phenols, Quinone and Phlobotannine, which have repellent activities against Sitophilus oryzae. Repellency test were also done using Methanol and petroleum ether leaf extract Annona muricata and Syzygium samarangense. No repellent activity were observed in Petroleum ether leaf extract of Annona muricata in all concentration. Methanol leaf extract of Annona muricata showed highest repellency of 61.33% at 6.4% concentration in 24 hrs. Petroleum ether leaf extract of Syzygium samarangense showed highest repellency of 55.00% at 6.4% concentration in 24 hrs, where on methanol leaf extract of Syzygium samarangense showed highest repellency of 60.00% at 6.4%. These leaf extracts can be used as an alternative biopesticides instead of chemical pesticides, which would be safer for storing rice grains.

Complete chloroplast genome sequence of Syzygium samarangense (Myrtaceae) and phylogenetic analysis

Syzygium samarangense (Blume) Merr. et Perry, 1938, commonly known as wax apple, is a Myrtaceae species that is known for its unique fruit shape, flavorful and colorful fruits, medicinal value and increasing economic relevance. In this study, we reported the complete chloroplast genome sequence of S. samarangense. The complete genome is 159,109 bp in length with a quadripartite structure containing two single copy regions, a Large Single Copy region (LSC, 88,155 bp) and a Small Single Copy region (SSC, 18,796 bp) separated by Inverted Repeat regions (IRs, 26,079 bp). The GC content was 37.0%. It encoded 126 genes, including 81 protein-coding genes, 37 transfer RNA genes, and 8 ribosomal RNA genes. The phylogenetic relationships of 20 species inferred that all Syzygium species formed a single cluster belonging to Syzygieae tribe. Our results offer insights into the evolutionary relationship of S. samarangense within Myrtaceae, indicating a closer relationship between S. samarangense and S. forrestii.

Syzygium samarangense leaf extract exhibits distinct antidiabetic activities: Evidences from in silico and in vivo studies

The wax apple, Syzygium samarangense , is widely used in traditional medicine. We have previously described a plethora of biological activities from its leaf extract. These include antioxidant, anti-inflammatory, antiulcer, antitrypanosomal and hepatoprotective effects. Here, we explored the antidiabetic activities from the bioactive leaf extract in silico on two crucial receptors involved in the management of diabetes disease namely peroxisome proliferator activated receptor gamma (PPARɣ) and glucagon like peptide-1 (GLP-1) and in vivo against streptozotocin-induced diabetic rats. Altogether, 457 secondary metabolites belonging to 10 classes (phenolic acids (86 compounds), flavonoids (139 compounds), anthocyanins (61 compounds), alkylphenols (17 compounds), chalcone (15 compounds), stilbenes (9 compounds), lignans (29 compounds), tannins (29 compounds), tyrosols (13 compounds), and terpenes and others (59 compounds), were docked into the active site of PPARɣ and GLP-1 receptors. From the PDB codes used for each receptor, the co-crystallized ligand was extracted and docked together with a known reference ligand. This was done simultaneously with docking the extract’s compounds to serve as references for comparative purposes. Out of the docked candidates, the top 30 compounds affording the best docking scores were compiled for further inspection and they appeared to exhibit better scores than the respective co-crystallized and reference ligands, highlighting the antidiabetic potential of the tested extract. Nine compounds exhibited highly negative scores on both receptors, demonstrating their high probability of being potent antidiabetic agents through forming stable ligand-receptor complexes. These activities were also confirmed in STZ diabetic rats where the extract reduced the elevated levels of serum glucose and lipid peroxides and increased the declined serum insulin hormone level. Taking all together, S. samarangense can be a potential candidate for further investigations for the treatment of numerous health disorders including diabetes.