Wavelength-swept Source Research Articles

High-power and high-speed all-optical all-fiber wavelength-swept source at 2 μm based on a femtosecond laser and time stretch technique

We present an all-fiber all-optical high-speed wavelength-swept laser source at 2 μm with a 3-dB bandwidth of 33 nm and repetition rate of 18.4 MHz, by using optical time-stretch technology, which to our knowledge is the first report of a 2 μm wavelength-swept source without any bulk, free-space optical elements. The light source is built upon a nonlinear polarization rotation mode-locked femtosecond oscillator. A chirped fiber Bragg grating (CFBG) is employed to realize the all-optical wavelength sweeping. In comparison with the commonly used dispersive fibers, the CFBG possesses outstanding power efficiency and temporal stability, especially for wavelength sweeping in the 2.0 μm wavelength regime. A two-stage fiber amplifier system is utilized to boost the output power up to 1.01 W. This all-fiberized mode-locked swept source with high speed and high stability shows great potential as a valuable source for various spectroscopy applications and swept source optical coherence tomography, particularly for highly scattering medium with low water content.

Swept-source Raman spectroscopy of chemical and biological materials.

Raman spectroscopy has been used as a powerful tool for chemical analysis, enabling the noninvasive acquisition of molecular fingerprints from various samples. Raman spectroscopy has proven to be valuable in numerous fields, including pharmaceutical, materials science, and biomedicine. Active research and development efforts are currently underway to bring this analytical instrument into the field, enabling in situ Raman measurements for a wider range of applications. Dispersive Raman spectroscopy using a fixed, narrowband source is a common method for acquiring Raman spectra. However, dispersive Raman spectroscopy requires a bulky spectrometer, which limits its field applicability. Therefore, there has been a tremendous need to develop a portable and sensitive Raman system. We developed a compact swept-source Raman (SS-Raman) spectroscopy system and proposed a signal processing method to mitigate hardware limitations. We demonstrated the capabilities of the SS-Raman spectroscopy by acquiring Raman spectra from both chemical and biological samples. These spectra were then compared with Raman spectra obtained using a conventional dispersive Raman spectroscopy system. The SS-Raman spectroscopy system used a wavelength-swept source laser (822 to 842nm), a bandpass filter with a bandwidth of 1.5nm, and a low-noise silicon photoreceiver. Raman spectra were acquired from various chemical samples, including phenylalanine, hydroxyapatite, glucose, and acetaminophen. A comparative analysis with the conventional dispersive Raman spectroscopy was conducted by calculating the correlation coefficients between the spectra from the SS-Raman spectroscopy and those from the conventional system. Furthermore, Raman mapping was obtained from cross-sections of swine tissue, demonstrating the applicability of the SS-Raman spectroscopy in biological samples. We developed a compact SS-Raman system and validated its performance by acquiring Raman spectra from both chemical and biological materials. Our straightforward signal processing method enhanced the quality of the Raman spectra without incurring high costs. Raman spectra in the range of 900 to were observed for phenylalanine, hydroxyapatite, glucose, and acetaminophen. The results were validated with correlation coefficients of 0.88, 0.84, 0.87, and 0.73, respectively, compared with those obtained from dispersive Raman spectroscopy. Furthermore, we performed scans across the cross-section of swine tissue to generate a biological tissue mapping plot, providing information about the composition of swine tissue. We demonstrate the capabilities of the proposed compact SS-Raman spectroscopy system by obtaining Raman spectra of chemical and biological materials, utilizing straightforward signal processing. We anticipate that the SS-Raman spectroscopy will be utilized in various fields, including biomedical and chemical applications.

High-speed reflectance confocal microscopy of human skin at 1251-1342 nm.

Reflectance confocal microscopy (RCM) is an imaging method that can noninvasively visualize microscopic features of the human skin. The utility of RCM can be further improved by increasing imaging speed. In this paper, we report high-speed RCM imaging of human skin with a frame rate that is over 10 times faster and an area imaging rate that is 6-9 times faster than those of commercially available RCM devices. The higher imaging speed was achieved using a high-speed RCM technique, termed spectrally encoded confocal microscopy (SECM). SECM uses a diffraction grating and a high-speed, wavelength-swept source to conduct confocal imaging at a very high rate. We developed a handheld SECM probe using a scanned-grating approach. The SECM probe was used in conjunction with a wavelength-swept source with a spectral band of 1251-1342 nm. The SECM probe achieved high lateral resolution of 1.3-1.6 µm and an axial resolution of 3.5 µm. SECM images of the human skin (image size = 439 × 439 µm2 ) obtained at 100 frames/s clearly show previously reported RCM features of the human skin in vivo with adequate image quality. The fast imaging speed allowed for the rapid acquisiton of volumetric SECM image data (200 frames covering a depth range of 200 µm) within 2 s. The use of 1251-1342 nm provided sufficient signal level and contrast required to visualize key cellular morphologic features. These preliminary results demonstrate that high-speed SECM imaging of the human skin at 1251-1342 nm is feasible.

Measurement of Complex Waveforms in Wide Wavelength Range by Using Wavelength-Swept Light Source and Linear Optical Sampling

Measurement of Complex Waveforms in Wide Wavelength Range by Using Wavelength-Swept Light Source and Linear Optical Sampling

High-Spatial-Resolution Strain and Vibration Dual-Parameter Sensor Based on Ultra-Short FBG

A method for simultaneous measurement of static strain and dynamic vibration with high spatial resolution based on millimeter sized ultra-short fiber Bragg grating (FBG) is proposed and experimented in this paper. Dual-parameter can be measured on the single unit of cascaded FBGs, which interrogate with optical coherence tomography method by a designed wavelength swept light source. In experiments, the sensing units were precisely located with mm degrees by inverse FFT of coherent signals and the phase difference calculation. And also the strain and vibration could be simultaneously measured in time and frequency domain: demodulating strain with low frequency component’s phase shift of coherent signals by extracting envelope and interpolation; demodulating vibration by finding peak positions of sidebands in FFT spectrum. Spatial resolution of positioning can reach 0.77 mm. Sensitivity of strain measurement reaches 0.811 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\boldsymbol{\times} 10^{-3} rad/\mu \varepsilon $</tex-math></inline-formula> under a wavelength sweep rate of 0.2 nm/ms, and forces of several milli newtons can be perceived. The measurement accuracy of kHz vibration frequency is over 98%. Moreover, by comparing simultaneous and respective measurement of dual-parameter, it can be seen that there is almost no crosstalk affectting the results. The results shows great application potential in the field of mechanical sensing, especially in bionic tactile sensing for its simultaneous dynamic and static measurement with accurate positioning performance.

High-speed wavelength-swept femtosecond source from 1055 to 1300 nm using a GHz femtosecond fiber laser.

In this Letter, we demonstrate a high-speed broadband wavelength-swept femtosecond source (WFS) that leverages the soliton self-frequency shift (SSFS) and intensity-wavelength encoding technologies. The optical wavelength of the high-speed WFS can be continuously swept from 1055 nm to nearly 1300 nm at a sweeping rate of 100 kHz. This WFS is especially seeded by a femtosecond mode-locked all-fiber laser at 1055 nm that has a fundamental repetition rate of ∼1.0 GHz, a maximum output power of 7 W, and a compressed pulse width of 220 fs. It is anticipated that this high-speed broadband WFS can be a promising source for applications that require fast wavelength scanning and high-speed data processing.

Comparative analysis of two optical biometry devices: high wavelength swept source OCT versus partial coherence interferometry

PurposeTo study the reproducibility of measurements performed with a recently developed multimodal high resolution swept source optical coherence tomography (SSOCT) and to make comparisons with a partial coherence interferometry (PCI) biometer.MethodsOne hundred and fifty-two eyes of 152 subjects were involved in this study with a mean age of 65.71 ± 13.86 years (26–85 years). Anterior surface keratometry (K), anterior chamber depth (ACD), white-to-white (WTW) and axial length (AL) values were recorded by the SSOCT (ANTERION, Heidelberg Engineering Ltd, Germany) and PCI (IOLMaster 500, version 5.5, Carl Zeiss Meditec, Germany). Intraocular lens (IOL) power was calculated based on ANTERION and IOLMaster keratometry values by using five traditional vergence formulas.ResultsAnterior surface simulated keratometry values did not differ significantly between the IOLMaster and ANTERION (P > 0.05). AL measurements were successful in 95% of the cases both with the SSOCT and PCI. No significant difference was disclosed between the two instruments (P = 0.229). For WTW measurements, a significant difference was observed between the two optical biometers (P < 0.0001). The difference between PCI and SSOCT in IOL powers was statistically significant for SRK/T, Hoffer and Holladay formulas (P < 0.001).ConclusionOur results implicated an overall good reproducibility of anterior keratometry, AL, ACD and WTW measurements for IOLMaster and ANTERION. The discrepancies between their measurements resulted in significant difference in the calculated IOL power for SRK/T, Hoffer and Holladay formulas, but not for Haigis formula.

Linear-in-wavenumber actively-mode-locked wavelength-swept laser.

We report on an akinetic actively-mode-locked wavelength-swept laser (ASL) with a sweep that is highly linear in wavenumber. By tailoring the drive waveform of the intracavity modulator, the wavenumber sweep was further linearized to enable high fidelity frequency-domain interferometric ranging without resampling of the acquired data. Used for catheter-based optical coherence tomography, the ASL showed comparable imaging performance to a state-of-the-art polygon-based wavelength-swept source at a matching sweep rate of 103.6 kHz, a duty cycle of 95%, and a bandwidth of 100 nm, centered at 1330 nm.

Compensation of Phase-Uncertainty-Induced Impairments in Dispersion-Tuned Swept Laser OCT using Digital Coherent Detection

The dispersion-tuned swept laser (DTSL) is a wavelength-swept source, which can achieve fast sweep without using any mechanical tunable filter. Such fast wavelength-swept sources are highly suitable for swept-source optical coherent tomography (SS-OCT). DTSL-based SS-OCT (DTSL-OCT) can deliver a very fast imaging speed, however, it suffers from a limited imaging depth due to the its limited coherence length. In this article, digital coherent detection techniques are applied to the DTSL-OCT to improve the imaging depth and axial resolution. We show that the two phase-uncertainty-induced impairments, namely, the image degeneracy and the wavelength-sweep-nonlinearity, can be compensated by signal processing on the complex interferometric signals acquired using digital coherent detector. Removal of the mirror images resulting from complex conjugate artifact enables the full-range measurement, and the wavelength-sweep-nonlinearity compensation improves the axial resolution. We experimentally demonstrated that the OPD corresponding to a 6 dB-drop in the point-spread function (PSF) peak level can be improved from 1.4 mm to 7.2 mm.

Steerable OCT catheter for real-time assistance during teleoperated endoscopic treatment of colorectal cancer.

When detected early, colorectal cancer can be treated with minimally invasive flexible endoscopy. However, since only specialized experts can delineate margins and perform endoscopic resections of lesions, patients still often undergo colon resections. To better assist in the performance of surgical tasks, a robotized flexible interventional endoscope was previously developed, having two additional side channels for surgical instrument. We propose to enhance the imaging capabilities of this device by combining it with optical coherence tomography (OCT). For this purpose, we have developed a new steerable OCT instrument with an outer diameter of 3.5 mm. The steerable instrument is terminated with a 2 cm long transparent sheath to allow three-dimensional OCT imaging using a side-focusing optical probe with two external scanning actuators. The instrument is connected to an OCT imaging system built around the OCT Axsun engine, with a 1310 nm center wavelength swept source laser and 100 kHz A-line rate. Once inserted in one of the side channels of the robotized endoscope, bending, rotation and translation of the steerable OCT instrument can be controlled by a physician using a joystick. Ex vivo and in vivo tests show that the novel, steerable and teleoperated OCT device enhances dexterity, allowing for inspection of the surgical field without the need for changing the position of the main endoscope.

Ultrabroadband wavelength-swept source based on total mode-locking of an Yb:CaF2 laser

We present an ultrabroadband, high-speed wavelength-swept source based on a self-modulated femtosecond oscillator. Photonic crystal fiber was pumped by a mode-locked Yb:CaF2 laser, resulting in a strong spectral broadening from 485 to 1800 nm. The pump laser cavity could be realigned in order to achieve total mode-locking of the longitudinal and transverse TEM00 and TEM01 electromagnetic modes. This led to spatial oscillations of the output beam, which induced modulation of the coupling efficiency to the fiber. Due to the fact that nonlinear spectral broadening was intensity dependent, this mechanism introduced wavelength sweeping at the fiber output. The sweeping rate could be adjusted between 7 and 21.5 MHz by changing the geometry of the pump cavity. By controlling the ratio of the transverse mode amplitudes, we were able to tune the sweeping bandwidth, eventually covering both the 1300 nm and 1700 nm bioimaging transparency windows. When compared with previously demonstrated wavelength-swept sources, our concept offers much broader tunability and higher speed. Moreover, it does not require an additional intensity modulator.

Long-to-short wavelength swept source.

Most swept external cavity diode lasers tune in the short-to-long wavelength direction (red tuning). Lower relative intensity noise (RIN) and higher output power are typically possible in this direction. We show here that long-to-short tuning (blue tuning) is possible for a short, linear cavity laser that has both low noise and high power. This mode of operation is made possible by nonlinear frequency broadening in the semiconductor optical amplifier (SOA) followed by clipping of the red portion of the spectrum by the micro-electro-mechanical systems (MEMS) tunable Fabry-Perot filter. Blue shifting during gain recovery is an important broadening mechanism. There is an approximate 50% advantage in coherence length for the same filter bandwidth for blue over red tuning, which allows deeper imaging in optical coherence tomography (OCT) applications. Calculations contrasting the blue tuning mechanism with red tuning are presented. The accuracy of the blue-tuning model is confirmed by coherence and coherence revival measurements and simulations.

Demonstration of Triband Multi-Focal Imaging with Optical Coherence Tomography.

We demonstrate an extended depth of focus optical coherence tomography (OCT) system based on the use of chromatic aberration to create displaced focal planes in the sample. The system uses a wavelength-swept source tuning over three spectral bands and three separate interferometers, each of which interfaces to a single illumination/collection fiber. The resulting three imaged volumes are merged in post-processing to generate an image with a larger depth of focus than is obtained from each band individually. The improvements are demonstrated in structural imaging of a porous phantom and a lipid-cleared murine brain, and by angiographic imaging of human skin. By using a coaxial approach with Gaussian beams, this approach enables an extended focus with relatively simple microscope optics and data-merging algorithms.

1.7 micron optical coherence tomography for vaginal tissue characterization in vivo.

Optical coherence tomography (OCT) can noninvasively visualize in vivo tissue microstructure with high spatial resolution that approaches the histologic level. Currently, OCT studies in gynecology are few and limited to a conventional 1.3 μm center wavelength swept light source which provides high spatial resolution but limited penetration depth. Here, we present a novel endoscopic OCT system with improved penetration depth and high resolution. A novel endoscopic OCT system was developed based on a 1.7 µm swept source laser, which is capable of deeper tissue penetration due to its longer wavelength. To evaluate the performance of system, we imaged the human vaginas in vivo with both conventional 1.3 and 1.7 μm endoscopic OCT systems. With the 1.7 μm endoscopic OCT system, imaging depth was improved by more than 25%, allowing better visualization of the lamina propria and clear contrast of the epithelial layer from the surrounding tissues. The significantly improved performance of the novel 1.7 μm OCT imaging system demonstrates its potential use as a minimally-invasive monitoring tool of vaginal health in gynecologic practice. Lasers Surg. Med. 51:120-126, 2019. © 2018 Wiley Periodicals, Inc.

Flexible pulse-stretching for a swept source at 2.0 μm using free-space angular-chirp-enhanced delay.

Dispersive pulse-stretching at 2.0μm has long been hindered by the high intrinsic optical loss from conventional dispersive media. Here a flexible pulse-stretching technique at 2.0μm is demonstrated over a broad bandwidth with large-scale dispersion and low intrinsic optical loss. The technique employs the newly proposed pulse-stretching scheme, namely, free-space angular-chirp-enhanced delay. Both normal and anomalous temporal dispersion (up to ±500 ps/nm) with low intrinsic loss (<6 dB) over a spectral bandwidth of ∼84 nm at 2.0μm is obtained with low nonlinear effects. Based on this method, an optical wavelength-swept source at 2.0μm is realized and applied to spectrally encoded imaging at a line scan rate of ∼19 MHz, proving the potential of this pulse-stretching technique for continuous single-shot measurements at the 2.0μm wavelength regime, particularly for optical microscopy and spectroscopy.

Intravascular Optical Coherence Tomography for Characterization of Atherosclerosis with a 1.7 Micron Swept-Source Laser

The main cause of acute coronary events, such as thrombosis, is the rupture of atherosclerotic plaques. Typical intravascular optical coherence tomography (IVOCT) imaging systems that utilize a 1.3 μm swept source laser are often used for identifying fibrous cap thickness of plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool. Here, we present a novel IVOCT system with a 1.7 μm center wavelength swept light source that can readily penetrate deeper into the tissue because of the longer wavelength and allows for better identification of plaques due to the lipid absorption spectrum at 1.7 μm. Using this system, we have imaged a human coronary artery to evaluate the performance of the novel OCT system and verified the results by hematoxylin and eosin (H&E) histology. The significantly improved imaging depth and better identification sensitivity suggest that the 1.7 μm OCT system holds great potential that can be further translated for in-vivo applications of atherosclerosis characterization.

High-speed wavelength-swept source at 2.0 μm and its application in imaging through a scattering medium.

We report a high-speed wavelength-swept source operating at 2.0 μm through advanced time-stretch technology. It sweeps over 30 nm at a speed of 3.3×109 nm/s and a repetition rate of ∼19 MHz. To the best of our knowledge, this is the first time that a megahertz-stable swept source has been implemented at such a long wavelength. A wide bandwidth is enabled by a simple mode-locked fiber laser that covers a wavelength range of ∼60 nm. The all-optical wavelength sweeping is realized by a chirped fiber Bragg grating (CFBG), which shows a superior temporal stability and power efficiency, compared with commonly used dispersive fibers, particularly in the 2.0 μm wavelength window. To showcase its specialties, here we employ it to perform high-speed spectrally-encoded microscopy (i.e., time-stretch imaging) through a scattering medium at a line-scan rate of up to ∼19 MHz. Better image quality is achieved, compared with a conventional imaging window at 1.0 μm. It is believed that the potential applications of this new high-speed swept source will benefit the transient diagnosis that requires deep penetration through a scattering medium.

High-speed OCT light sources and systems [Invited

Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light sources and swept source OCT systems.

Hyperspectral optical diffraction tomography.

Here, we present a novel microscopic technique for measuring wavelength-dependent three-dimensional (3-D) distributions of the refractive indices (RIs) of microscopic samples in the visible wavelengths. Employing 3-D quantitative phase microscopy techniques with a wavelength-swept source, 3-D RI tomograms were obtained in the range of 450 - 700 nm with a spectral resolution of a few nanometers. The capability of the technique was demonstrated by measuring the hyperspectral 3-D RI tomograms of polystyrene beads, human red blood cells, and hepatocytes. The results demonstrate the potential for label-free molecular specific 3-D tomography of biological samples.

Laser optomechanics.

Cavity optomechanics explores the interaction between optical field and mechanical motion. So far, this interaction has relied on the detuning between a passive optical resonator and an external pump laser. Here, we report a new scheme with mutual coupling between a mechanical oscillator supporting the mirror of a laser and the optical field generated by the laser itself. The optically active cavity greatly enhances the light-matter energy transfer. In this work, we use an electrically-pumped vertical-cavity surface-emitting laser (VCSEL) with an ultra-light-weight (130 pg) high-contrast-grating (HCG) mirror, whose reflectivity spectrum is designed to facilitate strong optomechanical coupling, to demonstrate optomechanically-induced regenerative oscillation of the laser optomechanical cavity. We observe >550 nm self-oscillation amplitude of the micromechanical oscillator, two to three orders of magnitude larger than typical, and correspondingly a 23 nm laser wavelength sweep. In addition to its immediate applications as a high-speed wavelength-swept source, this scheme also offers a new approach for integrated on-chip sensors.