Using phenothiazine as electron donor group, four novel visible light photoinitiators (10-methyl-phenothiazine-2-yl) (phenyl)methanone (MPO), (10-methyl-phenothiazine-2,8-diyl) bis(phenylmethanone) (MPBO), (E)-1-(10-methyl-phenothiazine-2-yl)-3-phenylprop-2-en-1-one (MPPO) and (2E,2′E)-1,1′-(10-methyl-phenothiazine-2,8-diyl) bis(3-phenylprop-2-en-1-one) (MPBPO) with D-A structure were synthesized by one-step method. The effect of conjugated structure and CC bond on the photophysical properties, solubility and migration ratio was discussed. With the degree of conjugation and the number of CC bond increases, the maximum absorption wavelength redshifted from 385 nm (MPO) to 414 nm (MPBO) and 400 nm (MPPO) to 430 nm (MPBPO) respectively. The charge transfer between the two-component photoinitiator system (Iod as co-initiator) can significantly improve the photopolymerization efficiency, the final CC double bond conversion can reach to 80 %, and the drying time of coatings was within 5–20 s. Moreover, all MPO, MPBO, MPPO and MPBPO have good solubility in different solvents and monomers. In addition, MPO, MPBO, MPPO and MPBPO shown low migration ratio and low cytotoxicity performance.