In efforts to improve detection sensitivity of shear wave elasticity imaging of target tissue lesions with relatively small mechanical contrast to the background tissues, shear wave propagation characteristics in tissues under compression loading have been studied. A finite element hyperelastic tissue model was constructed to characterize the changes of propagating shear wave subject to different mechanical loading and to guide in vitro experiments. The shear wave speed sharply increased in an inclusion from 2.4 m/s to 6.3 m/s while it increased from 2.0 m/s to 4.0 m/s in the background tissue with overall compression loading from 0% to 30%. Increased shear wave reflection at the boundary of the inclusion due to increased mechanical contrast was lowered using a directional filter. In vitro experiments were performed using a soft phantom block (0.5% agar with 5% gelatin) that contains a hard inclusion (1.5% agar with 5% gelatin) of a long cylinder (D: 8 mm). The reconstructed shear modulus of the inclusion exhibited noticeable nonlinearity, in contrast to linear increase of shear modulus in the surrounding phantom. As a result, the elastic modulus contrast of the inclusion to the surrounding phantom was increased from 0.47 to 1.41 at compression from 0% to 30%.
Read full abstract