Waterfront Region Research Articles

Side Chain Investigation of Imidazopyridazine as a Hinge Binder for Targeting Actionable Mutations of RET Kinase.

Actionable mutations of RET kinase have been identified as oncogenic drivers of solid tumors, including thyroid cancer, metastatic colorectal cancer, and nonsmall cell lung cancer. Although multikinase inhibitors and RET selective inhibitors are used to treat patients with RET alterations, there is insufficient research addressing certain issues: which actionable mutations arise from these therapies, how to improve the clinical response rate to RET inhibitors, and how to design new inhibitors to overcome drug resistance. Therefore, the development of sophisticated tool compounds is required to investigate the molecular mechanisms of actionable mutations and to develop breakthrough therapeutics for different RET alterations. Herein, we present our investigation into the side chains of imidazopyridazine hinge binders that are capable of inducing protein-ligand interaction patterns from the gatekeeper to the waterfront regions. Extending the substituents at the second and sixth positions enhanced the IC50 up to < 0.5 nM for diverse RET alterations.

Sea changes of sandbanks and reclamation of shallows in the middle reaches of the Yangtze River in the modern period

ABSTRACT The Yangtze River waterway is an open and dynamic natural system, where we see natural changes such as soil and water loss, river flooding, and rise and collapse of sandbanks and activities people carried out for land reclamation in the waterfront lowlands. Riverine island, a typical waterfront lowland, is formed by the sediment carried by the water from the middle and upper reaches of the Yangtze River when it is blocked, slowed down, and silted up in the process. It needs the protection of the dam. As important water conservancy facilities in lowland society, dams are, in fact, the result of state intervention and local self-organization governance. People’s adaptation to and transformation of the ecological environment in the waterfront region mainly revolves around the rise, collapse, and reclamation of the land and water control, which demonstrates the dynamic balance between “man and nature.” Since the late Qing, the north branch of Zhangjiazhou has gradually developed into a curved channel; the north bank has been eroded by water and accelerated to collapse, whereas the south bank has gradually silted up. The residents who lived on the north bank of the Yangtze River went to the south bank to reclaim land, resulting in continuous disputes over the reclamation of the new alluvial land. People realized their own demands for land reclamation by organizing groups beyond villages and families and using regulations on reclamation or land laws. This demonstrates that in the modern period the state and its institutional construction played a more important role in “confirming the rights” of the new alluvial land.

On boat: A magnificent panorama of River Basin in Tang Dynasty

Based on the framework of historical geography, this paper studies the panorama of Chinese river basin in Tang Dynasty, and attempts to reveal the connection between boat and panorama of river basin. Research uses logistic regression as method, takes 13,100 five-characters and eight-lines poems in Tang Dynasty as samples to study the influencing factors of boat. Results show that a total of 218 Chinese characters have a statistically significant effect on the factor of boat (P ≤ 0.05), including 141 risk factors and 77 protective factors. This research deepens the historical geography understanding of following nine aspects related to the “boat” in Tang Dynasty: ① waterfront regions, ② natural water systems, ③ aquatic animals & plants, ④ official travel, ⑤ fishery & commerce, ⑥ boat driving, ⑦ wonderful time, ⑧ emotion of boat trip, ⑨ daily life on boat.

RETRACTED: Research on the development and resource development of sports industry in coastal cities based on 5G network processor and IoT system

Data correspondence and calculation advances are profoundly meeting, and different remote access advances have been fruitful in organization. It tends to be anticipated that the impending fifth-age versatile correspondence innovation (5 G) cannot, at this point be defined by a solitary plan of action or precaution specialized trademark, The field of remote interchanges as the presentation of Fifth Generation (5 G) organization, which will be a defining moment in interchanges frameworks and lead to the making of unrivaled new frameworks and advancements. waterfront region and stood out it from our past 5 G remote access network research arranging that had executed in sports industry zone. Such densification of the organization could uphold various organizations and different cells inside 5 G and Internet of Things (IoT), and show how they change between two urban communities as indicated by a great deal of focuses. The more difficulties of the densification in 5 G during arranging of 5 G are network densification, range total Millimeter Wave (mm-Wave) groups and otherworldly productivity strategies, so more data transmission is required and Supporting versatility through such an exceptionally. The quantity of Coastal Cities Area (CCAs) situated close to mangroves increment from sports industry, the fast cycle has significant ramifications for coordinated biological system the executives. It is fundamental, accordingly, to fortify incorporated waterfront zone the board in zones in light of its association with the administrations that seaside and sports give to actual Industry.

EVALUASI LANSKAP SITU-FRONT SEBAGAI PENGEMBANGAN WATERFRONT DI KAWASAN CIBINONG RAYA, KABUPATEN BOGOR

Water resources is a natural element that has an important role in the development of a city. Not only on the land, development of the city can be done up to the water's edge. Among the aquatic and urban development zone of interaction it is called waterfront. the principle on planning a waterfront region is to build a public open space in urban areas that are physically and visually facing to the water (beach/river/lake) and can be a forum for community activities. To establish the identity and character of the city, Cibinong Raya was designed with Situ-front City because the city has 17 lakes on its territory. Those lakes in Cibinong Raya has different size and physical condition distinct from one another that could affect the priorities in its development. The study was conducted to evaluate the area around lakes in Cibinong Raya in accordance with waterfront development concept. Assessment on the condition of lakes in Cibinong Raya applies the criteria waterfront, riparian ecosystem status criteria, and the criteria for the status of aquatic ecosystems. The results showed that there are 3 lakes is in good condition and 4 lakes in passably condition to be developed into waterfront area.

EVALUASI LANSKAP SITU-FRONT SEBAGAI PENGEMBANGAN WATERFRONT DI KAWASAN CIBINONG RAYA, KABUPATEN BOGOR

Water resources is a natural element that has an important role in the development of a city. Not only on the land, development of the city can be done up to the water's edge. Among the aquatic and urban development zone of interaction it is called waterfront. the principle on planning a waterfront region is to build a public open space in urban areas that are physically and visually facing to the water (beach/river/lake) and can be a forum for community activities. To establish the identity and character of the city, Cibinong Raya was designed with Situ-front City because the city has 17 lakes on its territory. Those lakes in Cibinong Raya has different size and physical condition distinct from one another that could affect the priorities in its development. The study was conducted to evaluate the area around lakes in Cibinong Raya in accordance with waterfront development concept. Assessment on the condition of lakes in Cibinong Raya applies the criteria waterfront, riparian ecosystem status criteria, and the criteria for the status of aquatic ecosystems. The results showed that there are 3 lakes is in good condition and 4 lakes in passably condition to be developed into waterfront area.

AHP 기법을 적용한 제주지역 친수공간 자원화방안 요인의 중요도 분석

Recently, in the context of increased interest for marine tourism, Jeju region of South Korea has attractive waterfront space and also has potential requirements for development. The objective of this paper was to analyze the priority for resource development of waterfront in Jeju region. In order to calculate the importance of factors related to the development of waterfront in Jeju area, this study conducted exploratory factor analysis to extract the factors and established the AHP model based on the factors name focusing on a total of 198 tourists. In this study, in accordance with the procedures of AHP analysis, pairwise comparisons were conducted focusing on a total of 15 experts. Especially, difference test between groups (academics and bureaucratic) was conducted. In the 1st criterion for evaluation, `exploring experience` factor is most important thing and `facilities & infrastructure` factors were in the following order. In the secondary criterion, AHP analysis showed that experience facilities, environmental management, and absence of residents consciousness were the important factors. In the future time, the results of this research can be utilized as basic data in the aspects of tourism development in Jeju waterfront region.

Mangroves and Associated Flora of Vashista and Vainateyam Estuaries, A.P. India

Mangroves are highly productive ecosystems occurs intertidal regions only. Mangroves and associated flora occurring in two major estuaries of Godavari river (India) were studied using transect with 4x4 m2 quadrats and the quadrat samples were analyzed. Seasonal data were collected on environmental, hydrographical and chemical observations from three different stations of the two estuaries. Low values in Secchi depth, salinity and pH were reported during the monsoon season, while higher values were reported in pre-monsoon and post monsoon seasons. In the present study three mangrove species and nine associated species were reported. Transect studies in these two estuaries showed that mangrove and halophytes occurred up to 40 meters from water front region. In some places mangrove vegetation was in the form of long strips only. In Vainateyam estuary, the species with the highest density was Suaeda monoica whereas the species with lowest density was Avicennia officinalis. In Vashista estuary, maximum density was reported for Suaeda maritima and minimum density for Avicennia officinalis. The maximum height in these two stations varied from 5 to 8 meters only. Percentage frequencies of DBH (Density at Breast Height) classes were estimated. In the present study only two diameter classes were reported. This is indicative of the small and bushy mangrove vegetation in the region studied. Human interference, urban settlements and aqua industry play a critical impact on the survival of these tropical ecosystems. If management and conservation programmes are not undertaken, these ecosystems may be depleted.

Waterfront 지역의 주거환경 평가

The waterfront<TEX>$(W{\cdot}F)$</TEX> region can be one of the most significant resources as to the characteristics of Busan region. The research aims to find the essential factors to read the region fitted to the best residential environment, figuring out the estimation of being satisfied with the residential environment. On the basis of the survey it could be revealed that what kind of value the region can have and what kinds of factors have to be emphasized on the region development. As a result the Waterfront residential region has more satisfying like sight views and residential environmental than the non-waterfront residential region, showing high quality of perceiving the future moving plan. Some positive opinions could be found in insisting to develop the waterfront region, but it should be kept continually to prevent senseless developments, to develop the region fitting the demand to the provision, to manage the region continually since, and to observe some conservation criteria in developing the region.

古代末期のアレクサンドリアと後背地域のネットワーク

In regard to the Pirenne Thesis, a study should be made on how the medieval system was established and its relationship to late antiquity of Egypt. Accordingly, in this paper, the focus was on daily wares dating back to the Byzantine and early Islamic periods. The region, which most typically reflected the socio-economic system in Byzantine Egypt could be the Alexandria and Mareotis waterfront regions. Archaeological relics from Kellia show that these regions were characterized by the distribution of two kinds of Byzantine wares. One is “Late Roman C·D Ware” produced in Asia Minor and Cyprus, and could be a reflection of the Byzantine control of the Alexandrian market. Another is local ware, so-called “Abu Mina Group”, which can be divided into two groups, amphorae and pilgrim flasks, that are thought to reflect the economic and religious aspects of the region.From the topographical point of view, the network of Lake Mareotis and many canals, sustained the Mareotis region where the daily life, wine and olive production, fishing, etc. flourished in the Roman-Byzantine period. Coptic religious factors also seemed to effect the circulation of those daily wares. Therefore, Mediterranean cultural factors and local factors compounded the assemblage of relics and formed a mosaic patchwork in this region. This may be typical socio-economic aspect of late antiquity in Egypt.How Islamic influence has changed this system is not clear yet, but recent archaeological evidences indicate that from around the 9th century, some ceramics influenced by the Nubian culture prevailed, and if these ceramic wares were transported along with gold, emeralds and slaves, it can be recognized that a new “Islamic network” was established as its historical background and that the medieval lifestyle was completed around the 10th century, in the Fatimid period.

Qualitative consideration to design multiple regional metabolic system of water by way of wastewater reuse.

In this paper, the anther discusses a metabolic system of water through Sapporo city. Reuse of sewage treatment plant effluent by way of coagulation and sedementation in a natural lake and its ground water recharge by way of a canal is proposed. By the system, natural water bodies in and down stream of the city will turn into high level recreational water front regions and dual water supply system without additional transmission system to ensure stable water supply for the future will come out. By this kind of multiple purpose system, expenses of advanced wastewater treatment could be rationalized.

Multijurisdictional waterfront land use modeling

Abstract An increase in nontraditional uses of the waterfront in port cities has led to increased competition and conflict over the use of waterfront land. A multiobjective programming approach is developed for modeling land use decision‐making along the waterfront. The model is applied to the case of Charleston, South Carolina. Several waterfront regions where significant competition and conflict are likely to emerge among different user groups are identified by the analysis. Ways of using the model to facilitate conflict management among different user groups are discussed.