ABSTRACT The infertility of sandy soil hampers the growth of many crops. Typically, chemical fertilizers are used to handle this issue, but they are expensive and have deleterious implications on the ecosystem. A two-year field investigation was carried out on cowpea cultivated in sandy soil to assess the effects of different watering levels (70, 80, 90, and 100% of the actual irrigation requirements), chemical fertilizers, organic fertilizers, and biofertilizer (Bradyrhizobium sp.), and their combinations on the morpho-physiological traits and yield of cowpea (Vigna unguiculata L. Walp, cv. Giza 18). Overall, the findings showed that cowpea osmoregulatory molecules (sugars, proteins, and proline) demonstrated greater accumulation, with the content depending on the watering level. The applied fertilizers demonstrated improved cowpea performance at the regular watering level, with chopped potato tops outperforming other fertilizer formulations. Furthermore, the combination of water stress treatments and fertilizer formulations was impactful in relieving the detrimental consequences of water stress as it enhanced plant growth performance, production efficiency, metabolic homeostasis, nutritional value, and mineral ions composition. Subsequently, our results demonstrated agro-wastes, particularly chopped potato tops, could be an effective substitute for chemical fertilizers in sandy soils to sustainably increase soil fertility as well as cowpea yield performance.