Water Absorption Ratio Research Articles

Design And Evaluation of Fexofenadine Orally Disintegrating Tablets For Rapid Dissolution

Abstract: This study aims to formulate and evaluate Fexofenadine Oral Disintegration Tablets (ODTs), focusing on overcoming patient compliance issues related to taste and swallowing difficulties, especially in elderly and pediatric patients. Fexofenadine, a first-line treatment for type 2 diabetes, is used to enhance rapid dissolution, absorption, and bioavailability. Objectives included preparing tablets using direct compression and evaluating formulations through in-vitro tests such as weight variation, thickness, hardness, friability, drug content, wetting time, dispersion time, disintegration time, and dissolution studies. FTIR spectral analysis confirmed the presence of principal peaks and interactions between drugs and polymers. Results indicated a strong correlation (r = 0.998) between fexofenadine concentration and absorbance values. Tablets exhibited weight and thickness within pharmacoeial limits, with hardness, friability, and drug content meeting acceptable standards. Wetting time and water absorption ratio varied among formulations, with Cross povidone and Croscarmellose sodium showing superior performance. Disintegration times ranged from 17.66±0.51 to 171.83±1.16 seconds, with tablet formulations containing Cross povidone or combinations of super disintegrants (CP + CCS, CP + SSG) demonstrating rapid disintegration. In-vitro dispersion and dissolution studies reaffirmed these findings, suggesting these ODT formulations can significantly improve patient adherence, providing a quick onset of action and enhanced drug bioavailability. Further studies are recommended to establish extended in vivo performance and safety profiles, supporting the efficacy of fexofenadine ODTs in clinical settings.

Electric Conductivity Transitions of Water-Absorbable Polybenzimidazole Films.

Transitions seen in the electric properties of water-absorbable poly(2,5-benzimidazole) (ABPBI) films were confirmed by electric conductivity, dielectric constant, and time-domain nuclear magnetic resonance (NMR) measurements. The electric resistance of the films was measured at room temperature using a high-resistance meter, and the dielectric constant at room temperature was measured using an LCR meter in the frequency range of 90 Hz to 8 MHz. The water absorption ratio at equilibrium absorption for the films was 37%, which corresponded to a volume fraction of water of 0.33. The electric conductivity of the films without water absorption was ~1014 S·cm-1, and it increased to ~1010 S·cm-1 with increasing volume fraction, showing a percolation threshold at a volume fraction of 0.025, and remarkable transitions at volume fractions of 0.075 and 0.135. The dielectric constant of the films without water absorption was 3.4, and it increased to 8.1 with increasing volume fraction, showing a transition only at a volume fraction of 0.135. Above a volume fraction of 0.075, where a transition in conductivity was observed, there were two relaxation times at 18-31 μs and 20-93 μs, as determined from the time-domain NMR, and these relaxation times increased with increasing volume fraction. The longer relaxation time increased significantly at a volume fraction of 0.072, which was close to the volume fraction of the transition seen in conductivity. The relationship between the chain mobility of ABPBI and the deterioration in electric insulating properties is discussed.

Formulation, Development and Evaluation of Famotidine Orodispersible Tablets

Aim of the study: The main objective of present research work is to formulate the famotidine orodispersible tablets. Famotidine is a selective H2 receptor antagonist or H2 blocker belongs to BCS Class-II and is used to treat heartburn and duodenal ulcers. Materials and methods: The Orodispersible tablets of famotidine were prepared employing different concentrations of sodium starch glycolate, Crospovidone and Croscarmellose sodium in different combinations as superdisintegrants by direct compression. Mannitol and sodium saccharine were added to microcrystalline cellulose Magnesium stearate as a diluent to improve the organoleptic qualities of the tablets. using 23 factorial design mothod was used to formulate orodispersible tablet. Prepared tablets were then subjected to different tests for tablets like Wetting time, Water absorption ratio in-vitro disintegration time, thickness, diameter, hardness, friability, weight variation, drug content, and in-vitro dissolution study were all assessed for the tablets. Design expert study was conducted to know the interaction between different superdisintegrants and to select best optimized formulation in among all formulations. Results: The tablets' good mechanical strength was indicated by the hardness and friability data. The tablets quickly dispersed in the mouth in less than 12 seconds, according to the F5 in vitro disintegration time results respectively, and 99.24% of the drug release in 15 minutes. The optimal formulations of Famotidine Orodispersible tablets for enhancing the drug's bioavailability and onset of action were determined to be F5. Conclusion: The optimized formulation showed increased drug release compared to commercially available orodispersible tablets. No changes in disintegration time, drug content and in in vitro drug release from optimized formulation on storage for 1months at 40°C ± 2°C /75% RH ± 5% RH were observed during stability studies which confirmed the stability of the optimized formulation.

A multifunctional bacterial cellulose-based dressing modified by quaternized chitosan and grafted protocatechuic acid for diabetic ulcer.

Herein, we developed a multifunctional bacterial cellulose-based dressing (PHBC) modified by quaternized chitosan (HACC) along with protocatechuic acid (PA), through in situ biosynthesis combined with covalent immobilization. The obtained PHBC dressing maintained the excellent physicochemical characteristics of BC, such as high porosity (above 76 %); high water absorption ratio, >80 % of water absorption rate (approximately 30 g/g) has completed in half an hour; favorable hydrophilicity with contact angle of about 50° and excellent flexibility. The introduction of PA-grafted HACC endows exhibited outstanding antibacterial properties against, anti-inflammatory performance and antioxidant capacity. Furthermore, PHBC II, with the reaction solubility of PA was 3 mg/mL, could promote NIH3T3 and HUVECs proliferation and spread. In vivo experiments further verified that PHBC II can effectively promote new granulation tissue hyperplasia and collagen deposition and expression around diabetic ulcers, reduce the inflammatory phenomenon around the wound, and promote the internal capillaries of the wound. The repair and regeneration of the network can promote better and faster wound healing. These results illustrate that the PHBC functional dressing has an important reference value for the clinical treatment of diabetic ulcers.

Novel ceramic materials based on industrial wastes within the CaO–MgO–Al2O3–SiO2 system

The use of solid waste and raw materials such as ceramic sludge, klin rollers, magnesite, and limestone to produce low cost refractory ceramics after sintering at 1300 °C for 2 h was studied. Sample D30 with a composition of, 30 % diopside and 70 % mullite, was selected to be treated at 1200 °C for 2 h to investigate the effect of temperature on phase evolution. Microstructure, morphology and physical properties were also studied. Several techniques including XRF, XRD, SEM, EDX, flexural strength, and dielectric properties were used for samples characterisation. Densification parameters, morphology and microstructure were studied in order to evaluate the influence of the formed phases on the properties of produced ceramic materials. The study showed that the bulk density increased with the formation of corundum and mullite phases and decreased with the formation of anorthite and spinel phases. Bulk density also increased at higher firing temperatures. In contrast, porosity and water absorption showed the opposite trend to density. The main phases developed after firing at 1300 °C for 2 h were corundum, spinel, mullite, and anorthite. Flexural strength values were increased by increasing the precipitation pecent of corundum and mullite phases, as well as with bulk density. But it decreased with increasing porosity and both anorthite and spinel contents; ranging between 8.00 and 11.00 MPa. Bulk density increased with increasing of mullite content and temperature, ranging from 1.72 to 2.00 g/cm3, while porosity and water absorption ratio decreased from 32.59 to 22.10 and from 19.66 to 10.98, respectively. The microstructure morphology was converted from coarse-grained to fine-grained with increasing anorthite and spinel phases by increasing the temperature. To investigate the effect of the phases precipitated from the diopside-mullite system on their dielectric properties, parameters such as permeability (ε’), dielectric loss (ε′′), alternating current conductivity (σac) and Modulus'' were measured at the frequency range from 10−1 Hz–106 Hz. There is no noticeable effect on any of the dielectric parameters by increasing the concentration of diopside (CaMgSi₂O₆). In addition, the conductivity indicated that all the samples are insulators (σdc ≈ 10 pS/cm at f = 0.1 Hz) without any noticeable effect of composition.

Bond and tensile properties of flax textile reinforced recycled aggregate concrete: Strategies for interfacial enhancement and corresponding mechanisms

This study investigated the bond properties between flax fibre reinforced polymer (FFRP) mesh and various cementitious matrices, examining the impact of incorporating medium-sized recycled aggregates (2 – 8 mm). Enhancement strategies included modifying the FFRP surface with rice husk ash (RHA) and incorporating RHA into the cementitious matrix. Pull-out and uniaxial tensile tests were performed on FFRP reinforced mortar, FFRP reinforced recycled aggregate concrete (RAC), RAC reinforced with RHA-modified FFRP and RAC (containing RHA) reinforced with RHA-modified FFRP. The results showed that FFRP surface modification with RHA significantly improved bond strength, by 32 % compared to pulling normal FFRP from RAC. This was attributed to increased surface roughness of FFRP, enhanced chemical bonding due to pozzolanic reaction of RHA, and improved interfacial transition zone resulting from increased wettability and decreased water absorption ratio of the treated FFRP. Additionally, the inclusion of medium-sized recycled aggregates mitigated debonding by enhancing mechanical interlocking with the FFRP mesh. Compared to FFRP reinforced mortar, FFRP reinforced RAC and RHA-modified FFRP reinforced RAC exhibited increased strain capacity and refined crack propagation, indicating improved stress distribution. However, the enhanced anchoring reduced tensile strength by restricting the full utilisation of strain capacity in the post-cracking phase. These findings highlight the potential of surface modification of reinforcement with supplementary cementitious materials and the incorporation of medium recycled aggregates in the matrix to enhance bond performance and optimise the mechanical behaviour of cementitious composites.

A self-gelling alginate/chitosan based powder containing bioactive nanoparticles for non-compressible bleeding control and promoting wound healing

The challenge remains in developing hemostatic dressings that can fulfill both hemostatic and repair functions to meet clinical demands worldwide. Herein, the biodegradable powders composed of benzeneboronic acid-modified sodium alginate/catechol-modified quaternized chitosan hydrogel (SBQCC) networks and bioactive cerium oxide nanoparticles (CNPs), were prepared for hemostasis and promoting wound healing. The SBQCC/CNPs powders had good self-gelation ability, water absorption ratio, tissue adhesiveness and biocompatibility. The SBQCC/CNPs powders could not only rapidly absorb a large amount of blood to concentrate coagulation factors when applied on bleeding wounds, but also formed an adhesive hydrogel physical barrier to control bleeding in situ. Meanwhile, the aggregation and activation of red blood cells and platelets induced by the SBQCC/CNPs powders can initiate the forming of internal blood clot with fibrin to further enhance the hemostatic effect. The SBQCC/CNPs powders demonstrated excellent hemostatic performance in non-compressible rat tail vein bleeding and rabbit liver bleeding models. In addition, SBQCC/CNPs powder-derived hydrogels had antibacterial activity and multiple biological activities, including antioxidant, anti-inflammatory and promoting angiogenesis for accelerating wound healing. Therefore, the SBQCC/CNPs powders can accelerate wound healing while achieving effective hemostasis, which will be a promising hemostatic dressing.

Assessing disintegration effectiveness: A thorough evaluation using the SeDeM-ODT expert system for doxylamine succinate orodispersible formulation.

The SeDeM-ODT expert system is designed to assess the suitability of the pharmaceutical ingredients for their conversion into an orodispersible formulation by direct compression. The tool can be utilized to select the most appropriate excipients that improve the compressibility and buccodispersibility of the formulation. This study aimed to utilize the SeDeM-ODT expert system to evaluate the performance of superdisintegrants and select an appropriate superdisntegrant for Doxylamine Succinate orodispersible formulation. The SeDeM-ODT expert system scrutinized the excipients to develop an orodispersible Doxylamine Succinate formulation. Among the 15 parameters of the tool, some of them were determined through experimental work, while the remaining were calculated through the experimental values of other parameters. The central composite design approach was used for formulation development. The prepared powder blends were compressed using the direct compression method and evaluated for different parameters (hardness, thickness, diameter, friability, weight variation, water absorption ratio, wetting time, and disintegration time). The results of the SeDeM-ODT expert system were correlated with the values obtained by the post-compression tests. The Crospovidone formulation (F7) was found to be an optimized formulation as it disintegrated quickly compared with the other formulations containing other superdisintegtrants. The results perfectly endorsed the SeDeM-ODT expert system evaluation, as Crospovidone showed the highest IGCB value of 6.396. The study observed the effectiveness of the expert system in accurately examining the performance of disintegrating agents. The study observed the effectiveness of the expert system in accurately examining the performance of disintegrating agents. The assessment proved Crospovidone to produce quicker disintegration in Doxylamine Succinate orodispersible formulation.

The Effect of Adding the Mishraq Sulfur Ore on the Physical and Chemical Properties of Al-Angor and Al-Nahrawan Clays to Producing Lightweight Bricks

This paper aims to examine the possibility of producing lightweight laboratory clay Bricks by adding sulfur ore powder in different weight ratios ranging from 0, 10, 20, 30, 40, to 50% as supplementary materials to two types of clays taken from two different sites, which is the Al-Angor clay region near the city of Ramadi and the Al-Nahrawan clay region. The bricks burned at temperatures of 950 and 1050 C°٬ and the longitudinal Shrinkage tests, bulk density, water absorption, compression strength, and efflorescence were measured. The X-ray diffraction analysis was executed to determine the formed metal phases. The results of the tests showed a direct proportion between longitudinal contraction and water absorption ratio with the addition of sulfur ore and high burning temperature. While bulk density and compression strength are inversely proportional to the sulfur ratio and high burning temperature. Efflorescence tests showed a decrease in the efflorescence rate with an increase in the proportion of sulfur ore.

Effect of kyron T-134 and crospovidone as a fast disintegrating agent on formulation properties of fast dissolving tablet containing ketorolac and rizatriptan using direct compression method

Background and objective: Fast dissolving tablets (FDTs) are "they are uncoated tablets that are supposed to be placed in the mouth and dispersed quickly before being swallowed" within minutes. This study aimed to formulate and evaluate a combination of ketorolac and rizatriptan as orally fast-dissolving tablets using the most common and easiest method to treat migraine attacks with or without aura. To investigate the effects of various types of diluents and super disintegrants on wetting time, water absorption ratio, disintegration, and dissolution time of combined drugs (ketorolac and rizatriptan) as oral dissolving tablets prepared by direct compression technique. Methods: Pre-formulation experiments were carried out in order to rule out any physicochemical interactions between the two medications (ketorolac and rizatriptan) as well as between each drug and its excipients. Four different formulations of fast-dissolving tablets with different types and ratios of diluents and super disintegrants were created using the direct compression technique in order to improve the formulation. Organoleptic characteristics, weight variation, thickness, friability, hardness, disintegration duration, wetting duration, water absorption ratio, drug content, in-vitro dissolution, stability, and comparison tests have all been characterized. Results: According to FT-IR, the two drugs and excipients exhibit no physicochemical interactions. The ideal formula F4 contains crospovidone and Kyron T-134 at optimal concentrations of 2.5% and 2.5%, respectively, and provides the majority of pharmaceutical drugs to be released within the first five minutes, a strong stability profile, the shortest wetting time with the fastest disintegration time (10 sec), and a pleasant flavor (strawberry flavoring agent). Conclusion: Kyron T-134 with Crospovidone in a (1:1) ratio provided rapid disintegration. Ketorolac tromethamine and rizatriptan benzoate may be made into fast-dissolving oral tablets using Kyron T-134 and Crospovidone. Improving migraine compliance is a reasonable goal.

Effect of Microbial Degradation Treatments on Lignocellulose, Cellulose, and Water-Holding Capacity of Four Typical Forest Fuels from Northeast China

Since forest fuel decomposes slowly and increases the risk of forest fires by accumulating over the years, forest fuel management to accelerate the decomposition process is essential to prevent forest fires and protect forest resources. In this study, we conducted experiments on forest fuels (Pinus sylvestris var. mongholica, Larix gmelinii, Quercus mongolica and Fraxinus mandshurica) in four typical plantation forests in northeast China by adding Trichoderma spp. to investigate the decomposition process and the changes in cellulose, hemicellulose and the water-holding capacity of the fuels. The addition of Trichoderma spp. accelerated the decomposition of cellulose, hemicellulose and lignin in the fuel. Trichoderma spp. promoted the ratio of water absorption and loss, as well as the water-holding capacity of the fuels. The ratio of water absorption and loss reached equilibrium when the decomposition time was up to 35 days, and the addition of Trichoderma spp. increased the maximal water-holding capacity of the fuel. The residual ratio of the four types of fuel degraded by the different treatments was inversely proportional to their maximal water-holding capacities and to the residual ratios of cellulose, hemicellulose and lignin. The residual ratios of degradation of the four fuels under different treatments were linearly related to their maximum water-holding capacity, cellulose, hemicellulose and lignin residual ratios. Trichoderma spp. had a positive effect on the degradation effect and water-holding capacity of fuel on the ground surface of four typical plantation forests. The study is of positive significance for the decomposition of fuel in forests, it promotes the development of biological fire prevention technology and provides a basis for the reinforcement of the management of fuel in forests and the protection of forest resources.

Optimizing compressive strength prediction using adversarial learning and hybrid regularization

The infrastructure industry consumes natural resources and produces construction waste, which has a detrimental impact on the environment. To mitigate these adverse effects and reduce raw material consumption, waste materials can be repurposed to achieve sustainability. However, recycled materials deteriorate the intrinsic properties of concrete. A suitable ratio of natural resources and recycled aggregates can produce the desired compressive strength. Compiling sufficient data in civil engineering laboratories to make reliable conclusions is time-consuming and costly. Therefore, this research proposes a novel approach for predicting compressive strengths using limited data. The generative adversarial network was employed to generate synthetic data. Hybrid training, utilizing either conventional loss or heuristic loss, prevents the model from overfitting by adaptively adjusting the regularization term. Random noise from a multivariate normal distribution is embedded heuristically into the training samples to capture intricate data variations. Sensitivity analysis indicated that the size of recycled coarse aggregate and water are the most significant features, aligning with their correlations. Interestingly, superplasticizer, density of recycled coarse aggregate, and water absorption ratio of recycled coarse aggregate contributed significantly to predictions despite their low correlations. The propounded method outperforms random forest, support vector regression, artificial neural network, and adaptive boosting by scoring a mean squared error of 7.97, a root mean squared error of 2.82, a mean absolute error of 2.13, and a coefficient of determination of 0.96. These results suggest that the proposed technique can effectively contribute to sustainable construction practices by accurately predicting compressive strengths.

Novel collagen gradient membranes with multiphasic structures: Preparation, characterization, and biocompatibility

Scaffolds with multiphasic structures are considered to be superior for guided tissue regeneration. Two types of tilapia skin collagen gradient membranes (stepped gradient and linear gradient) with multiphasic structures were prepared by controlling the collagen concentrations and the freezing rates. The results revealed that collagen gradient membranes were more capable of guiding tissue regeneration compared to homogeneous membranes. These two gradient membranes featured a dense outer layer and a loose inner layer, with good mechanical properties as indicated by tensile strengths of more than 250 Kpa and porosities exceeding 85 %. Additionally, these membranes also showed good hydrophilicity and water absorption, with an inner layer contact angle of less than 91° and a water absorption ratio greater than 40 times. Furthermore, the multiphasic scaffolds were proved to be biocompatible by the acute toxicity assay, the intradermal irritation test and so on. Gradient membranes could effectively promote the adhesion and proliferation of fibroblasts and osteoblasts, through elevating the TGF-β/Smad signaling pathway by TGF-β and Smads, and activating the Wnt/β-catenin signaling pathway by LRP5 and β-catenin, similar to homogenous membranes. Therefore, collagen gradient membranes from tilapia skin show important application value in guiding tissue regeneration.

Eco-friendly concrete: Combining treated wastewater and recycled aggregates.

The concrete industry is a significant consumer of drinking water and natural aggregates, such as sand and gravel. However, the scarcity of water and aggregate resources and the challenges associated with the disposal of construction and demolition waste prompted the exploration of alternative materials. This study investigates the feasibility of incorporating secondary treated wastewater from UASB reactors followed by trickling filters and mixed recycled aggregates as potential alternatives. To assess the viability of these alternatives, the study considered the replacement of 100% potable water with treated wastewater, as well as varying proportions of recycled gravel (20, 40, 60, 80, and 100%) and recycled sand (10, 20, 30, 40, and 100%). Physical and mechanical properties were negatively affected, but it was possible to reach compressive results over 40 MPa and splitting tensile strength over 4 MPa for almost all mixes. Regarding physical properties, the use of alternative materials caused poorer outcomes for density, water absorption, and air-void ratio. The limited magnitude of these detrimental effects indicates the potential of manufacturing concrete with the addition of combined treated wastewater and recycled aggregate as a viable strategy while enhancing reuse practices.

Enhancing fresh strawberry preservation: Fabrication and characterization of electrospun fibers decorated with functionalized graphene oxide

AbstractThis study focuses on developing an innovative packaging material for fresh strawberries composed of electrospun poly(ε‐caprolactone) (PCL)/poly(vinylpyrrolidone) (PVP) fibers decorated by pure graphene oxide (GO) and functionalized GOs with silane agents using the electrospinning technique. Initially, synthesized GO was first functionalized by silane agents, and followed by the fabrication of electrospun PCL/PVP fibers incorporating both pure GO and functionalized GOs. The surface morphological analyses revealed the uniformity, smoothness, and beadless in the fabricated fibers. The average fiber diameter of the PCL/PVP/0.5A‐GO fibers was found as 3244 ± 56 nm. Electrospun PCL/PVP/0.5A‐GO and PCL/PVP/0.5G‐GO fibers exhibited increased water absorption ratios over 20 days. The incorporation of GO into the polymer matrix, along with an increase in GO concentration, enhanced the tensile strength of the fibers, found as 5.149 ± 0.032 kPa. In preservation tests on fresh strawberries, PCL/PVP/0.5A‐GO fibers demonstrated superior freshness compared with unpacked strawberries and other variants. The study also highlighted the inhibitory effects of fibers decorated with 0.5% APTES‐GO, showing the highest inhibition zone. In summary, fibers incorporating 0.5% A‐GO effectively extended the shelf‐life of fresh strawberries, making them a promising packaging material for perishable goods.

Fabrication and hemostasis evaluation of a carboxymethyl chitosan/sodium alginate/Resina Draconis composite sponge

Hemostasis is the first step of emergency medical treatment. It is particularly important to develop rapid-acting and efficacious hemostatic materials. Carboxymethyl chitosan (CMCS), sodium alginate (SA) and Resina Draconis (RD) were composited uniformly by polyelectrolyte blending. Their composite sponges (CMCS/SA/RD) were prepared by freeze-induced phase separation. CMCS/SA/RD sponges were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy, and their blood absorption and hemolysis ratio were analyzed. The hemostatic effect of the composite sponges was evaluated by coagulation in vitro and in vivo. The composite sponges had a porous network structure. The water absorption ratio was >8000 %, and hemolysis ratio was <5 %. CMCS/SA/RD-II and CMCS/SA/RD-III composite sponges shortened the coagulation time in vitro by 11.33 s and 9.66 s, the hepatic hemostasis time by 13.8 % and 23.3 %, and the hemostasis time after mouse-tail amputation by 28.9 % and 23.9 %, respectively. A preliminary study on its coagulation mechanism showed that CMCS/SA/RD had significant effects on erythrocyte adsorption, platelet adhesion, and shortening of the activated partial thromboplastin time.

Optimizing water Absorption’s influence on composite mechanics through response surface methodology

This study systematically examines how different fiber contents—Diss, Sisal, and luffa—affect the mechanical properties of bio-composites at rates of 10%, 15%, and 25%, with a particular focus on water absorption behavior. It investigates the relationship between water absorption and bending behavior, utilizing response surface methodology (RSM) optimization and analysis of variance (ANOVA) to thoroughly analyze input parameters, including a 44-day absorption duration, fiber type, and fiber content. The findings reveal that sisal-reinforced composites demonstrate the highest flexural strength, with an average stress of 31.15 ± 1.82 MPa for a 10% sisal fiber rate. However, an increase in fiber content leads to a decrease in mechanical properties and an increase in water absorption, with water absorption ratios of 2%, 3% and 5% for sisal biocomposites at fiber rates of 10%, 15% and 25%, respectively. The study’s reliability is confirmed by a significant R-squared coefficient of 0.94, indicating strong consistency between predicted and observed results. This comprehensive investigation offers valuable insights into how varying fiber content impacts both mechanical performance and water absorption in fiber-reinforced composites.

Biomass-based solar evaporation: Sustainable solutions for efficient and eco-friendly water supply

Biomass materials with features of low-cost, environmentally friendly, and renewable have received significant attention in the field of solar-driven evaporation. However, their evaporation flux is far behind than those of petroleum-based evaporations, owing to the non-rational design of water supply and thermal insulation. Herein, an efficient biobased solar evaporation is developed using konjac-derived aerogel as water transport material and bamboo-derived carbon black as photothermal material. By the means of morphology optimization and structural dimensional design, the biobased evaporator exhibits excellent water supply with water absorption ratio of 10 g g−1 and good thermal insulation with low thermal conductivity of 0.113 W m−1 K−1. As a result, the all-biomass interfacial evaporation achieves an optimal evaporation flux of 3.77 kg m−2 h−1 with photothermal conversion efficiency of 97.2 % under 1-sun illumination, representing one of the best results of biomass based solar evaporation so far. More importantly, the fabrication of evaporators is environmentally friendly without any involvement of organic solvents, strong acids, or strong bases, which satisfy the demands for sustainable development and green society.

Formulation &amp; Evaluation of Anti Migrane Mouth Dissolving Tablet

The objective of this study is to improve the safety, efficacy, and rate of action of the existing molecule by utilising novel techniques to the administration of medication. This will be accomplished by the application of novel approaches. Orally disintegrating pills containing rizatriptan benzoate were made by the direct compression technique in order to provide migraine sufferers with a more expedient manner of gaining relief from their condition. For the purpose of this inquiry, a 32-factororial design method was utilised, and eight different formulations were examined for each of the super disintegrants that were explored. There were a number of tests that were performed on the batches of tablets that were manufactured. These tests included weight variation, hardness, friability, wetting time, invitro dispersion time, drug content, and invitro dissolution. A UV spectrophotometric approach that is easy, sensitive, rapid, accurate, cost-effective, and repeatable was created in order to identify the dose form of Rizatriptan Benzoate tablets. This method was designed in order to determine the dose form. It has been determined that rizatriptan benzoate has the maximum absorbance at a wavelength of 225 nm, and its molar absorption is measured to be 1.619 Ao. According to Beer's law, the application of the law was observed between 1 and 10 μg/ml. In order to validate the conclusions of the investigation, statistical analysis and recovery studies were carried out. In order to validate the method, a number of various criteria were utilised. These criteria included linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), Sandell's sensitivity, and specificity were among the criteria that were utilised. The practice of determining the regular dosage of Rizatriptan Benzoate in both tablet and bulk forms was found to be one that is accurate and precise via the utilisation of the preferred method. This was identified through the utilisation of the recommended method. A time period ranging from fifteen to thirty seconds was required for the optimised formulation to be distributed throughout the body. Furthermore, it demonstrated a greater water absorption ratio and released 99.60% of the medication over a period of two minutes and fifteen seconds. This was in addition to everything else that it shown.

Tannic acid-crosslinked gelatin composite microspheres adsorbed with CQAS or Ca2+ for rapid hemostasis

In the case of massive blood loss due to natural disasters and wars, timely and rapid hemostasis is of great significance to improve the survival rate of injured people. Nevertheless, uncontrolled, noncompressible, and irregular bleeding wounds remain a giant challenge for rapid hemostasis. In this study, the tannic acid-crosslinked gelatin was first obtained by Michael addition reaction, and then the tannic acid-crosslinked gelatin composite microspheres (TGMs) were prepared by the emulsion cross-linking method. TGMs could significantly improve the water absorption and hemostatic performance compared with single component gelatin microspheres (GMs). Increasing the water absorption ratio and introducing blood coagulation factors into composite materials are simple and effective strategies to enhance the hemostatic properties. Therefore, chitosan quaternary ammonium salt (CQAS) and Ca2+ were electrostatic adsorbed to obtain two kinds of functional TGMs, which were respectively CQAS-absorbed TGMs (T2GMs-CQAS) and calcium ion-absorbed TGMs (T2GMs-Ca2+). Notably, T2GMs-CQAS, and T2GMs-Ca2+ could absorb water rapidly within 3 seconds, in addition, especially the water absorption ratio of T2GMs-CQAS could reach 2.95 times compared with GMs. Benefited from rapid water absorption, coagulation pathway activation, and red blood cells aggregation of T2GMs-CQAS and T2GMs-Ca2+, resulting in rapid blood coagulation in vitro. In addition, CQAS and Ca2+ provided strong and intrinsic antibacterial activity due to positive charge. Moreover, in the tail amputation and liver hemostatic models, T2GMs-CQAS and T2GMs-Ca2+ demonstrated superior hemostatic effects compared to commercial Yunnan Baiyao®. In conclusion, T2GMs-CQAS and T2GMs-Ca2+ have potential applications as hemostatic dressings in uncontrolled, noncompressible, and irregular bleeding wounds.