This study explores a novel integration of electro-physicochemical technologies to generate energy and treat water from combined food waste (FW) and blackwater (FW-BW), with BW containing waste activated sludge with simulated flush water. The FW-BW substrate was gravity-separated and pretreated with hydrodynamic cavitation (HDC). Solids from gravity separation were used for energy generation via anaerobic digestion (AD) alone or integrated with microbial electrolysis cells (AD-MEC). HDC pretreatment had 51.6% more CH4 production in 5 days (266 mL CH4/g VS) and 63% more in 30 days compared to AD without HDC. The CH4 production after 5 days of digestion with HDC pretreatment (266 mL CH4/g VS) was similar to the amount produced without HDC over 30 days (263 mL CH4/g VS). Using MEC increased CH4 production by 12.7% compared to AD-only. The liquids from gravity separation were treated with electrocoagulation (EC) at 15 V (90 min), which removed 96.2% of the chemical oxygen demand (COD) and 100% of the total suspended solids. The pilot scale design indicates that the AD-MEC and EC units would generate 1.4 times more energy than energy consumed through applying these novel technologies. These findings demonstration the applications of four technologies (HDC, AD, MEC, and EC) in an energy-efficient waste management approach, producing bioenergy and cleaner water for low-tier use, especially in areas lacking traditional waste treatment options.